Only a handful of clinical trials have looked at the effects of Coleus forskohlii in humans. Most of these trials have administered 250 mg of Coleus forskohlii extract standardized to contain 10% forskolin twice per day, for a total daily dose of 500 mg of Coleus forskohlii extract, equivalent to 50 mg of forskolin.

Because supplementation with Coleus forskohlii extract or forskolin has been noted to reduce blood pressure, increase stomach acid levels, and inhibit platelet aggregation, it should be used with caution by people with hypotension (low blood pressure) or who are taking antihypertensive (blood-pressure-lowering) drugs, people with blood clotting disorders or who are taking blood thinning medication, and people with stomach ulcers.^[1]