Dosage information

Formulation:

Grape seed extract is usually available in liquid extracts, tablets, or capsules. Its main active ingredient is oligomeric proanthocyanidin complexes (OPCs); some formulations may have varying amounts.

Range of dosages studied:

100 to 2,100 mg per day

Examine Database: Grape Seed Extract

Show Conditions

Health Condition/Goal	Health Outcome	Evidence
General Cardiovascular Health	9 outcomes	9 Studies
Metabolic Health	6 outcomes	3 Studies
Cardiovascular Disease	6 outcomes	2 Studies
Type 2 Diabetes	5 outcomes	1 Study
Breast Cancer	2 outcomes	1 Study
Dyslipidemia	2 outcomes	1 Study
Metabolic Syndrome	6 outcomes	3 Studies
Skin Health	1 outcome	1 Study

General Cardiovascular Health

9 outcomes

9 Studies

Metabolic Health

6 outcomes

3 Studies

Cardiovascular Disease

6 outcomes

2 Studies

Type 2 Diabetes

5 outcomes

1 Study

Breast Cancer

2 outcomes

1 Study

Dyslipidemia

2 outcomes

1 Study

Metabolic Syndrome

6 outcomes

3 Studies

Skin Health

1 outcome

1 Study

General Cardiovascular Health

Metabolic Health

Cardiovascular Disease

Research FeedRead all studies

Grape seed extract for nonalcoholic fatty liver disease

In this randomized controlled trial in participants with nonalcoholic fatty liver disease, daily supplementation with grape seed extract improved a variety of cardiometabolic risk factors.

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Grape seed extract for older adults with cognitive impairment

Does supplementing with bilberry and grape seed extract improve cardiometabolic health?

Does a grape and blueberry extract supplement improve cognitive function in older adults?

Frequently asked questions

What is the history of grape seed extract, and how was it discovered?

What’s the difference between grape seed extract and pycnogenol?

What are other names for Grape Seed Extract?

Update History

All new FAQs were added to this page.
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Research written by

Louie Neri

Edited by

Conni Covington

Reviewed by

Giulia Guerrini

Research Breakdown

References

Examine Database References

C-Reactive Protein (CRP) - Kar P, Laight D, Rooprai HK, Shaw KM, Cummings MEffects of grape seed extract in Type 2 diabetic subjects at high cardiovascular risk: a double blind randomized placebo controlled trial examining metabolic markers, vascular tone, inflammation, oxidative stress and insulin sensitivityDiabet Med.(2009 May)
Blood Flow - Clifton PMEffect of Grape Seed Extract and Quercetin on Cardiovascular and Endothelial Parameters in High-Risk SubjectsJ Biomed Biotechnol.(2004)
Blood Pressure - Feringa HH, Laskey DA, Dickson JE, Coleman CIThe effect of grape seed extract on cardiovascular risk markers: a meta-analysis of randomized controlled trialsJ Am Diet Assoc.(2011 Aug)
Blood Flow - Shenoy SF, Keen CL, Kalgaonkar S, Polagruto JAEffects of grape seed extract consumption on platelet function in postmenopausal womenThromb Res.(2007)
High-density lipoprotein (HDL) - Vigna GB, Costantini F, Aldini G, Carini M, Catapano A, Schena F, Tangerini A, Zanca R, Bombardelli E, Morazzoni P, Mezzetti A, Fellin R, Maffei Facino REffect of a standardized grape seed extract on low-density lipoprotein susceptibility to oxidation in heavy smokersMetabolism.(2003 Oct)
Leg Edema - Sano A, Tokutake S, Seo AProanthocyanidin-rich grape seed extract reduces leg swelling in healthy women during prolonged sittingJ Sci Food Agric.(2012 Jul 2)
Triglycerides - Sivaprakasapillai B, Edirisinghe I, Randolph J, Steinberg F, Kappagoda TEffect of grape seed extract on blood pressure in subjects with the metabolic syndromeMetabolism.(2009 Dec)
Estrogen - Ikuko Kijima, Sheryl Phung, Gene Hur, Sum-Ling Kwok, Shiuan ChenGrape seed extract is an aromatase inhibitor and a suppressor of aromatase expressionCancer Res.(2006 Jun 1)
Food Intake - Vogels N, Nijs IM, Westerterp-Plantenga MSThe effect of grape-seed extract on 24 h energy intake in humansEur J Clin Nutr.(2004 Apr)
Oxidative Stress Biomarkers - S L Nuttall, M J Kendall, E Bombardelli, P MorazzoniAn evaluation of the antioxidant activity of a standardized grape seed extract, LeucoselectJ Clin Pharm Ther.(1998 Oct)
Hyperpigmentation - Yamakoshi J, Sano A, Tokutake S, Saito M, Kikuchi M, Kubota Y, Kawachi Y, Otsuka FOral intake of proanthocyanidin-rich extract from grape seeds improves chloasmaPhytother Res.(2004 Nov)

Grape Seed Extract

Overview

What is grape seed extract?

What are grape seed extract’s main benefits?

How does grape seed extract work?

Dosage information

Formulation:

Range of dosages studied:

Examine Database: Grape Seed Extract

Research FeedRead all studies

Frequently asked questions

What is the history of grape seed extract, and how was it discovered?

What’s the difference between grape seed extract and pycnogenol?

What are other names for Grape Seed Extract?

Update History

All new FAQs were added to this page.
major

Research Breakdown

References

Examine Database References

Examine Database References

Research FeedRead all studies

Examine Database: Grape Seed Extract

Grape Seed Extract

Overview

What is grape seed extract?

What are grape seed extract’s main benefits?

How does grape seed extract work?

Dosage informationMedical disclaimer

Formulation:

Range of dosages studied:

Examine Database: Grape Seed Extract

Research FeedRead all studies

Frequently asked questions

What is the history of grape seed extract, and how was it discovered?

What’s the difference between grape seed extract and pycnogenol?

What are other names for Grape Seed Extract?

Update History

All new FAQs were added to this page.major

Research Breakdown

References

Examine Database References

Examine Database References

Research FeedRead all studies

Examine Database: Grape Seed Extract

Dosage information

All new FAQs were added to this page.
major