Grape Seed Extract

    Researchedby:
    Kamal Patel
    Last Updated: October 13, 2024

    Grape Seed Extract is a mixture of tannins and procyanidins (chains of catechins) that appears to exert anti-estrogenic effects and may enhance blood flow. More related to green tea catechins than to resveratrol mechanistically.

    Grape Seed Extract is most often used for Men’s Health. The Examine Database covers General Cardiovascular Health, Metabolic Health, and 6 other conditions and goals.

    282 participants in 10 trials and 1 meta-analysis

    What are other names for Grape Seed Extract?

    Note that Grape Seed Extract is also known as:
    • GSE
    • OPC-3
    • Oligomeric Procyanidins
    • Procyanidin
    Grape Seed Extract should not be confused with:

    Dosage information

    Studies conducted in humans used in the range of 150-300mg Grape Seed extract daily for heart health purposes, while doses up to 600mg have been used with no reported side effects.

    Examine Database: Grape Seed Extract

    Research FeedRead all studies

    Research Breakdown

    Examine Database References

    1. C-Reactive Protein (CRP) - Kar P, Laight D, Rooprai HK, Shaw KM, Cummings MEffects of grape seed extract in Type 2 diabetic subjects at high cardiovascular risk: a double blind randomized placebo controlled trial examining metabolic markers, vascular tone, inflammation, oxidative stress and insulin sensitivityDiabet Med.(2009 May)
    2. Blood Flow - Clifton PMEffect of Grape Seed Extract and Quercetin on Cardiovascular and Endothelial Parameters in High-Risk SubjectsJ Biomed Biotechnol.(2004)
    3. Blood Pressure - Feringa HH, Laskey DA, Dickson JE, Coleman CIThe effect of grape seed extract on cardiovascular risk markers: a meta-analysis of randomized controlled trialsJ Am Diet Assoc.(2011 Aug)
    4. Blood Flow - Shenoy SF, Keen CL, Kalgaonkar S, Polagruto JAEffects of grape seed extract consumption on platelet function in postmenopausal womenThromb Res.(2007)
    5. High-density lipoprotein (HDL) - Vigna GB, Costantini F, Aldini G, Carini M, Catapano A, Schena F, Tangerini A, Zanca R, Bombardelli E, Morazzoni P, Mezzetti A, Fellin R, Maffei Facino REffect of a standardized grape seed extract on low-density lipoprotein susceptibility to oxidation in heavy smokersMetabolism.(2003 Oct)
    6. Leg Edema - Sano A, Tokutake S, Seo AProanthocyanidin-rich grape seed extract reduces leg swelling in healthy women during prolonged sittingJ Sci Food Agric.(2012 Jul 2)
    7. Triglycerides - Sivaprakasapillai B, Edirisinghe I, Randolph J, Steinberg F, Kappagoda TEffect of grape seed extract on blood pressure in subjects with the metabolic syndromeMetabolism.(2009 Dec)
    8. Estrogen - Ikuko Kijima, Sheryl Phung, Gene Hur, Sum-Ling Kwok, Shiuan ChenGrape seed extract is an aromatase inhibitor and a suppressor of aromatase expressionCancer Res.(2006 Jun 1)
    9. Food Intake - Vogels N, Nijs IM, Westerterp-Plantenga MSThe effect of grape-seed extract on 24 h energy intake in humansEur J Clin Nutr.(2004 Apr)
    10. Oxidative Stress Biomarkers - S L Nuttall, M J Kendall, E Bombardelli, P MorazzoniAn evaluation of the antioxidant activity of a standardized grape seed extract, LeucoselectJ Clin Pharm Ther.(1998 Oct)
    11. Hyperpigmentation - Yamakoshi J, Sano A, Tokutake S, Saito M, Kikuchi M, Kubota Y, Kawachi Y, Otsuka FOral intake of proanthocyanidin-rich extract from grape seeds improves chloasmaPhytother Res.(2004 Nov)