Supplementing with HMB at a dose of 3 grams per day appears to be well tolerated and is not associated with any adverse side effects.[1] This is the dose commonly used in research studies. Higher doses may be equally safe, but very few studies have investigated doses of HMB above 3 grams per day. One study found that 6 grams of HMB per day didn’t cause any concerning changes to cholesterol, blood glucose, red or white blood cells, and liver or kidney function.[2] HMB also appears to be safe when taken with other amino acids (i.e., arginine, lysine, and glutamine) or supplemented alongside creatine.[3][1][4]