Rose Hip
•Last Updated: September 28 2022
Rose hip, the fruit of Rosa canina, is a dietary supplement for joint health. It can alleviate symptoms of arthritis if taken daily.
Rose Hip is most often used for
Last Updated: September 28 2022
Rose hip is a term used to refer to the extracts of rose plant fruit (of the Rosagenus), but it almost always refers specifically to Rosa canina, commonly known as the dog rose.
The fruits, and occasionally seeds, of dog rose are either ground up into a powder or made into tea, then supplemented to treat rheumatic diseases like osteoarthritis and rheumatoid arthritis. It improves joint health by reducing pain and stiffness.
Preliminary evidence also suggests rose hip may provide benefits to people with diabetes, as well as high blood pressure and cholesterol. It’s hypothesized that rose hip may have an anti-obesity effect, but this claim needs to be confirmed through research.
Rose hip alleviates joint pain through its immunosuppressive effects. The immune system can contribute to rheumatic diseases. An inflammatory cytokine called Interleukin 1-Beta (IL-1β) causes cartilage cells to produce proteins that digest and break down join tissue. In moderation, this process encourages cell turnover, but in excess, this process contributes to long-term joint tissue degradation, which is what causes joint problems. While rose hip doesn’t reduce IL-1β levels in the blood, it interferes with its ability to activate catabolic proteins.
Rose hip is also able to reduce chemotaxis, which is the transportation of immune cells into tissue. This serves as both an anti-inflammatory and immunosuppressive mechanism.
Note that Rose Hip is also known as:
- Rosa canina
- Dog Rose
- Cynosbati fructus
- Fructae cynosbati
The standard dose for rose hip is 5-10g a day, divided into two doses.
Rose hip powder is usually the preferred form of the supplement.
Rose hip should be taken with meals.
Doses as high as 40g have been used in studies. Aside from some intestinal distress, taking this much rose hip is not harmful.
1.^Chrubasik C1, Roufogalis BD, Müller-Ladner U, Chrubasik SA systematic review on the Rosa canina effect and efficacy profilesPhytother Res.(2008 Jun)
2.^Roman I1, Stănilă A, Stănilă SBioactive compounds and antioxidant activity of Rosa canina L. biotypes from spontaneous flora of TransylvaniaChem Cent J.(2013 Apr 23)
3.^Uggla M, Gao X, Werlemark GVariation Among and Within Dogrose Taxa ( Rosa sect. caninae ) in Fruit Weight, Percentages of Fruit Flesh and Dry Matter, and Vitamin C ContentActa Agr Scand B-S P.(2003)
4.^Demir F, Özcan MChemical and technological properties of rose (Rosa canina L.) fruits grown wild in TurkeyJ Food Eng.(2001 Mar)
6.^Larsen E, Kharazmi A, Christensen LP, Christensen SBAn antiinflammatory galactolipid from rose hip (Rosa canina) that inhibits chemotaxis of human peripheral blood neutrophils in vitroJ Nat Prod.(2003 Jul)
7.^Salminen JP1, Karonen M, Lempa K, Liimatainen J, Sinkkonen J, Lukkarinen M, Pihlaja KCharacterisation of proanthocyanidin aglycones and glycosides from rose hips by high-performance liquid chromatography-mass spectrometry, and their rapid quantification together with vitamin CJ Chromatogr A.(2005 Jun 10)
8.^Nagatomo A1, Nishida N2, Matsuura Y2, Shibata N3Rosehip Extract Inhibits Lipid Accumulation in White Adipose Tissue by Suppressing the Expression of Peroxisome Proliferator-activated Receptor GammaPrev Nutr Food Sci.(2013 Jun)
9.^Ninomiya K1, Matsuda H, Kubo M, Morikawa T, Nishida N, Yoshikawa MPotent anti-obese principle from Rosa canina: structural requirements and mode of action of trans-tilirosideBioorg Med Chem Lett.(2007 Jun 1)
10.^Saaby L1, Jäger AK, Moesby L, Hansen EW, Christensen SBIsolation of immunomodulatory triterpene acids from a standardized rose hip powder (Rosa canina L.)Phytother Res.(2011 Feb)
11.^Saaby L1, Nielsen CHTriterpene acids from rose hip powder inhibit self-antigen- and LPS-induced cytokine production and CD4⁺ T-cell proliferation in human mononuclear cell culturesPhytother Res.(2012 Aug)
12.^Ziegler SJ1, Meier B, Sticher OFast and Selective Assay of l-Ascorbic Acid in Rose Hips by RP-HPLC Coupled with Electrochemical and/or Spectrophotometric DetectionPlanta Med.(1986 Oct)
13.^Tayefi-Nasrabadi H1, Sadigh-Eteghad S, Aghdam ZThe effects of the hydroalcohol extract of Rosa canina L. fruit on experimentally nephrolithiasic Wistar ratsPhytother Res.(2012 Jan)
14.^Türkben C, Uylaşer V, İncedayı B, Çelikkol IEffects of different maturity periods and processes on nutritional components of rose hip (Rosa canina L.)J Food Agr Environ.(2010)
15.^Horváth G1, Molnár P, Radó-Turcsi E, Deli J, Kawase M, Satoh K, Tanaka T, Tani S, Sakagami H, Gyémánt N, Molnár JCarotenoid composition and in vitro pharmacological activity of rose hipsActa Biochim Pol.(2012)
16.^Chen SS, Spiro MRose-hip tea: equilibrium and kinetic study of mineral ion extractionFood Chem.(1993)
17.^Başgel S1, Erdemoğlu SBDetermination of mineral and trace elements in some medicinal herbs and their infusions consumed in TurkeySci Total Environ.(2006 Apr 15)
18.^Larsen E, Christensen LPCOMMON VEGETABLES AND FRUITS AS A SOURCE OF 1,2-DI-O-α-LINOLENOYL-3-O-β-D-GALACTOPYRANOSYL-sn-GLYCEROL, A POTENTIAL ANTI-INFLAMMATORY AND ANTITUMOR AGENTJ Food Lipids.(2007 Sep)
19.^Gao X, Björk L, Trajkovski V, Uggla MEvaluation of antioxidant activities of rosehip ethanol extracts in different test systemsJ Sci Food Agr.(2000 Nov)
20.^Frész T1, Nagy E2, Hilbert A2, Tomcsányi J3The role of flavonoids in false positive digoxin assays caused by the consumption of hibiscus flower and rose hip teaInt J Cardiol.(2014 Feb 1)
21.^Andersson U1, Berger K, Högberg A, Landin-Olsson M, Holm CEffects of rose hip intake on risk markers of type 2 diabetes and cardiovascular disease: a randomized, double-blind, cross-over investigation in obese personsEur J Clin Nutr.(2012 May)
22.^Fajas L, Debril MD, Auwerx JPeroxisome proliferator-activated receptor-gamma: from adipogenesis to carcinogenesisJ Mol Endocrinol.(2001 Aug)
23.^Goto T1, Teraminami A, Lee JY, Ohyama K, Funakoshi K, Kim YI, Hirai S, Uemura T, Yu R, Takahashi N, Kawada TTiliroside, a glycosidic flavonoid, ameliorates obesity-induced metabolic disorders via activation of adiponectin signaling followed by enhancement of fatty acid oxidation in liver and skeletal muscle in obese-diabetic miceJ Nutr Biochem.(2012 Jul)
24.^Andersson U1, Henriksson E, Ström K, Alenfall J, Göransson O, Holm CRose hip exerts antidiabetic effects via a mechanism involving downregulation of the hepatic lipogenic programAm J Physiol Endocrinol Metab.(2011 Jan)
25.^Nagatomo A, Nishida N, Fukuhara I, Noro A, Kozai Y, Sato H, Matsuura YDaily intake of rosehip extract decreases abdominal visceral fat in preobese subjects: a randomized, double-blind, placebo-controlled clinical trialDiabetes Metab Syndr Obes.(2015 Mar 6)
26.^Goldring SR1, Goldring MBThe role of cytokines in cartilage matrix degeneration in osteoarthritisClin Orthop Relat Res.(2004 Oct)
27.^Reboul P1, Pelletier JP, Tardif G, Cloutier JM, Martel-Pelletier JThe new collagenase, collagenase-3, is expressed and synthesized by human chondrocytes but not by synoviocytes. A role in osteoarthritisJ Clin Invest.(1996 May 1)
28.^Struglics A1, Larsson S, Pratta MA, Kumar S, Lark MW, Lohmander LSHuman osteoarthritis synovial fluid and joint cartilage contain both aggrecanase- and matrix metalloproteinase-generated aggrecan fragmentsOsteoarthritis Cartilage.(2006 Feb)
29.^Schwager J1, Hoeller U, Wolfram S, Richard NRose hip and its constituent galactolipids confer cartilage protection by modulating cytokine, and chemokine expressionBMC Complement Altern Med.(2011 Nov 3)
30.^Lotz M1, Moats T, Villiger PMLeukemia inhibitory factor is expressed in cartilage and synovium and can contribute to the pathogenesis of arthritisJ Clin Invest.(1992 Sep)
31.^Alaaeddine N1, Di Battista JA, Pelletier JP, Kiansa K, Cloutier JM, Martel-Pelletier JDifferential effects of IL-8, LIF (pro-inflammatory) and IL-11 (anti-inflammatory) on TNF-alpha-induced PGE(2)release and on signalling pathways in human OA synovial fibroblastsCytokine.(1999 Dec)
32.^Shakibaei M1, Allaway D, Nebrich S, Mobasheri ABotanical Extracts from Rosehip (Rosa canina), Willow Bark (Salix alba), and Nettle Leaf (Urtica dioica) Suppress IL-1β-Induced NF-κB Activation in Canine Articular ChondrocytesEvid Based Complement Alternat Med.(2012)
33.^Winther K1, Rein E, Kharazmi AThe anti-inflammatory properties of rose-hipInflammopharmacology.(1999)
34.^Ginnerup-Nielsen E, Christensen R, Bliddal H, Zangger G, Hansen L, Henriksen MImproved gait in persons with knee related mobility limitations by a rosehip food supplement: A randomized, double-blind, placebo-controlled trialGait Posture.(2015 Sep)
35.^Kharazmi A, Winther KRose hip inhibits chemotaxis and chemiluminescence of human peripheral blood neutrophils in vitro and reduces certain inflammatory parameters in vivoInflammopharmacology.(1999)
36.^Kirkeskov B, Christensen R, Bügel S, Bliddal H, Danneskiold-Samsøe B, Christensen LP, Andersen JRThe effects of rose hip (Rosa canina) on plasma antioxidative activity and C-reactive protein in patients with rheumatoid arthritis and normal controls: a prospective cohort studyPhytomedicine.(2011 Aug 15)
37.^Willich SN, Rossnagel K, Roll S, Wagner A, Mune O, Erlendson J, Kharazmi A, Sörensen H, Winther KRose hip herbal remedy in patients with rheumatoid arthritis - a randomised controlled trialPhytomedicine.(2010 Feb)
38.^Bellamy N, Buchanan WW, Goldsmith CH, Campbell J, Stitt LWValidation study of WOMAC: a health status instrument for measuring clinically important patient relevant outcomes to antirheumatic drug therapy in patients with osteoarthritis of the hip or kneeJ Rheumatol.(1988 Dec)
39.^Winther K, Apel K, Thamsborg GA powder made from seeds and shells of a rose-hip subspecies (Rosa canina) reduces symptoms of knee and hip osteoarthritis: a randomized, double-blind, placebo-controlled clinical trialScand J Rheumatol.(2005 Jul-Aug)
40.^The Effects of a Standardized Herbal Remedy Made from a Subtype of Rosa canina in Patients with Osteoarthritis: A Double-Blind, Randomized, Placebo-Controlled Clinical Trial
41.^Rein E1, Kharazmi A, Winther KA herbal remedy, Hyben Vital (stand. powder of a subspecies of Rosa canina fruits), reduces pain and improves general wellbeing in patients with osteoarthritis--a double-blind, placebo-controlled, randomised trialPhytomedicine.(2004 Jul)
42.^Dolganiuc A, Stavaru C, Anghel M, Baltaru D, Georgescu E, Olinescu AThe migratory and phagocytic activity of polymorphonuclear leukocytes in rheumatoid arthritis and osteoarthritis patientsRoum Arch Microbiol Immunol.(2000 Jan-Jun)
43.^Park UH1, Jeong JC, Jang JS, Sung MR, Youn H, Lee SJ, Kim EJ, Um SJNegative regulation of adipogenesis by kaempferol, a component of Rhizoma Polygonati falcatum in 3T3-L1 cellsBiol Pharm Bull.(2012)
44.^Witczak CA1, Sharoff CG, Goodyear LJAMP-activated protein kinase in skeletal muscle: from structure and localization to its role as a master regulator of cellular metabolismCell Mol Life Sci.(2008 Nov)
45.^Habinowski SA1, Witters LAThe effects of AICAR on adipocyte differentiation of 3T3-L1 cellsBiochem Biophys Res Commun.(2001 Sep 7)
46.^Phetcharat L, Wongsuphasawat K, Winther KThe effectiveness of a standardized rose hip powder, containing seeds and shells of Rosa canina, on cell longevity, skin wrinkles, moisture, and elasticityClin Interv Aging.(2015 Nov 19)
47.^Tominaga K, Hongo N, Karato M, Yamashita ECosmetic benefits of astaxanthin on humans subjectsActa Biochim Pol.(2012)
48.^Bottari A1, Belcaro G, Ledda A, Luzzi R, Cesarone MR, Dugall MLady Prelox® improves sexual function in generally healthy women of reproductive ageMinerva Ginecol.(2013 Aug)
49.^Bottari A1, Belcaro G, Ledda A, Cesarone MR, Vinciguerra G, Di Renzo A, Stuard S, Dugall M, Pellegrini L, Errichi S, Gizzi G, Ippolito E, Ricci A, Cacchio M, Ruffini I, Fano F, Hosoi MLady Prelox® improves sexual function in post-menopausal womenPanminerva Med.(2012 Dec)
50.^Bottari A1, Belcaro G, Ledda A, Cesarone MR, Vinciguerra G, Di Renzo A, Stuard S, Dugall M, Pellegrini L, Errichi S, Gizzi G, Ippolito E, Ricci A, Cacchio M, Ruffini I, Fano F, Hosoi MLady Prelox® improves sexual function in post-menopausal womenPanminerva Med.(2012 Nov 9)
51.^Errichi S1, Bottari A, Belcaro G, Cesarone MR, Hosoi M, Cornelli U, Dugall M, Ledda A, Feragalli BSupplementation with Pycnogenol® improves signs and symptoms of menopausal transitionPanminerva Med.(2011 Sep)