Last Updated: December 22, 2023

S-adenosylmethionine (SAMe) is a methyl donating compound that circulates in the blood and provides methyl groups to maintain other metabolic reactions. Lowered SAMe levels are associated with depressive symptoms, and supplementation may aid a partial deficiency.

S-adenosylmethionine is most often used for


S-adenosylmethionine (SAMe) is the amino acid methionine bound to an ATP molecule; this molecule circulates in the blood naturally and acts as a 'methyl donor'. A methyl group in chemistry is simply a carbon molecule (bound to some hydrogens), and donating a methyl group to other molecules can accelerate or preserve reactions in the body as a form of metabolic 'maintenance'. Choline is another prominent methyl donor in the body, but due to selectivity of some reactions the two are not necessarily interchangeable.

Some body states appear to be associated with lower circulating levels of SAMe, including osteoarthritis and depression where SAMe appears to hold potent therapeutic potential; after a build-up period of 1-2 months, supplemental SAMe at 800-1600mg daily appears to be as potent as some pharmaceutical options for both osteoarthritis and depression and appears to enhance some anti-depressants. Although lower circulating levels of SAMe are also seen in diabetes, the benefits of SAMe and glucose control are not as well established as depression and osteoarthritis.

SAMe appears to follow many nutrient-like motifs in the body, being regulated within a certain serum range and being associated with adverse effects when that range is perturbed. It potentially holds a lot of benefit in body states where circulating SAMe levels decline.

Although side-effects are not commonly reported with SAMe, numerous studies note a small set of participants who experience mania after supplementing SAMe. It is not common, but it does appear to be related to SAMe supplementation for unknown reasons; it has been reported in some persons without history of mania as well and does not appear to be related to any pathological condition per se.

What are other names for S-adenosylmethionine?
Note that S-adenosylmethionine is also known as:
  • SAME
  • SAMe
  • Ademethionine
  • S-adenosyl-L-methionine
  • Adomet
S-adenosylmethionine should not be confused with:
  • Methionine (the isolated amino acid)
Dosage information

Supplementation of S-adenosylmethionine tends to be in the 600-1,200mg range over the course of a day, divided into two or three separated doses with meals. The higher dosage (1,200mg) tends to be used more often, with the lower dosage (600mg) being used to cut costs.

For S-adenosylmethionine to benefit osteoarthritis, it appears to require a few weeks or up to a month of continual usage for benefits to show. Benefits to depressive symptoms may be much more rapid.

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