Silymarin

    Written by:
    Daryl Nault, Nick Milazzo

    Fact-checked

    by:

    Nick Milazzo
    Last Updated: February 21, 2024

    Silymarin is a complex mixture of plant-derived compounds extracted from milk thistle. It mostly contains flavonolignans and flavonoids, which have antioxidant and anti-inflammatory properties.

    13 references on this page
    5,448 participants in trials and 7 meta-analyses

    Overview

    Examine Database: Silymarin

    Frequently asked questions

    Update History

    Examine Database References

    1. Liver Enzymes - de Avelar CR, Pereira EM, de Farias Costa PR, de Jesus RP, de Oliveira LPMEffect of silymarin on biochemical indicators in patients with liver disease: Systematic review with meta-analysis.World J Gastroenterol.(2017-Jul-21)
    2. Liver Enzymes - Georgios Kalopitas, Christina Antza, Ioannis Doundoulakis, Antonis Siargkas, Elias Kouroumalis, Georgios Germanidis, Myrto Samara, Michail ChourdakisImpact of Silymarin in individuals with nonalcoholic fatty liver disease: A systematic review and meta-analysisNutrition.(2021 Mar)
    3. Liver Enzymes - Zhong S, Fan Y, Yan Q, Fan X, Wu B, Han Y, Zhang Y, Chen Y, Zhang H, Niu JThe therapeutic effect of silymarin in the treatment of nonalcoholic fatty disease: A meta-analysis (PRISMA) of randomized control trialsMedicine (Baltimore).(2017 Dec)
    4. Liver Enzymes - Kailin Yang, Junpeng Chen, Tianqing Zhang, Xiao Yuan, Anqi Ge, Shanshan Wang, Hao Xu, Liuting Zeng, Jinwen GeEfficacy and safety of dietary polyphenol supplementation in the treatment of non-alcoholic fatty liver disease: A systematic review and meta-analysisFront Immunol.(2022 Sep 9)
    5. Liver Enzymes - Fakhri M, Fakheri H, Azadbakht M, Moosazadeh M, Yousefi SSEffect of Medicinal Plants and Natural Products on Liver Enzymes in Non-alcoholic Fatty Liver Patients in Iran: A Systematic Review and Meta-Analysis.Int J Prev Med.(2022)
    6. Liver Enzymes - Saller R, Brignoli R, Melzer J, Meier RAn updated systematic review with meta-analysis for the clinical evidence of silymarin.Forsch Komplementmed.(2008-Feb)
    7. Liver Enzymes - Yang Z, Zhuang L, Lu Y, Xu Q, Chen XEffects and tolerance of silymarin (milk thistle) in chronic hepatitis C virus infection patients: a meta-analysis of randomized controlled trials.Biomed Res Int.(2014)