Liver Enzymes

    Last Updated: October 13, 2024

    Liver enzymes are used as biomarkers to test the toxicity of a supplement and are elevated in case of fatty or cirrhotic liver. Lower blood levels are thought to reflect less-damaged liver cells.

    53,726 participants in 221 trials

    Summary

    The most common liver enzymes are aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP), and gamma-glutamyl transpeptidase (GGT).

    Examine Database: Liver Enzymes

    InterventionGradeEffectDetail
    Curcumin
    B
    Mediterranean Diet
    D
    Resveratrol
    B
    Intermittent fasting (IF)
    Synbiotics
    Vitamin D
    Propolis
    Black seed
    Astaxanthin
    Saffron
    Vitamin E
    Conjugated Linoleic Acid
    Chlorella
    Creatine
    Pycnogenol
    N-Acetylcysteine
    TUDCA
    L-Carnitine
    Spirulina
    Betaine
    Nicotinamide Mononucleotide
    Kefir
    S-adenosylmethionine
    Rose Hip
    Lactobacillus Reuteri
    Chromium
    Tetradecyl Thioacetic Acid
    Coenzyme Q10
    Silymarin
    Eleuthero
    Panax Ginseng (Korean Ginseng)
    Kava
    Cinnamon
    Olive Leaf Extract
    Ashwagandha
    HMB
    Fish Oil
    Garlic
    Bitter Cucumber
    Artichoke Extract
    Citrulline
    Probiotics
    Ketogenic Diet
    Tongkat Ali
    Rhodiola Rosea
    Black Cohosh
    Kutki
    Bulbine Natalensis
    Bushman's hat
    Terminalia Arjuna
    Jiaogulan
    Dill
    King of Bitters
    Whey Protein
    Theanine
    Phosphatidylserine
    Glutamine
    Leucine
    Niacin (Vitamin B3)
    Vitamin C
    Hesperidin
    Red Clover Extract
    Pterostilbene
    Brown Seaweed Extract
    Boron
    Melatonin
    DHEA
    Ecdysteroids
    Perilla
    Green Coffee Extract
    Korean black raspberry
    Tribulus Terrestris
    Royal Jelly
    Reishi
    Cordyceps
    Roselle
    Cocoa Extract
    Nattokinase
    PQQ
    Inositol
    Honey
    Sumac

    Research FeedRead all studies

    Examine Database References

    1. Kutki - Vaidya AB, Antarkar DS, Doshi JC, Bhatt AD, Ramesh V, Vora PV, Perissond D, Baxi AJ, Kale PMPicrorhiza kurroa (Kutaki) Royle ex Benth as a hepatoprotective agent--experimental & clinical studiesJ Postgrad Med.(1996 Oct-Dec)
    2. Brown Seaweed Extract - Abidov M, Ramazanov Z, Seifulla R, Grachev SThe effects of Xanthigen in the weight management of obese premenopausal women with non-alcoholic fatty liver disease and normal liver fatDiabetes Obes Metab.(2010 Jan)
    3. Pterostilbene - Riche DM, McEwen CL, Riche KD, Sherman JJ, Wofford MR, Deschamp D, Griswold MAnalysis of safety from a human clinical trial with pterostilbeneJ Toxicol.(2013)
    4. Olive Leaf Extract - Susalit E, Agus N, Effendi I, Tjandrawinata RR, Nofiarny D, Perrinjaquet-Moccetti T, Verbruggen MOlive (Olea europaea) leaf extract effective in patients with stage-1 hypertension: comparison with CaptoprilPhytomedicine.(2011 Feb 15)
    5. Conjugated Linoleic Acid - A J Wanders, L Leder, J D Banga, M B Katan, I A BrouwerA high intake of conjugated linoleic acid does not affect liver and kidney function tests in healthy human subjectsFood Chem Toxicol.(2010 Feb)
    6. Niacin (Vitamin B3) - Westphal S, Borucki K, Taneva E, Makarova R, Luley CExtended-release niacin raises adiponectin and leptinAtherosclerosis.(2007 Aug)
    7. Conjugated Linoleic Acid - Iwata T, Kamegai T, Yamauchi-Sato Y, Ogawa A, Kasai M, Aoyama T, Kondo KSafety of dietary conjugated linoleic acid (CLA) in a 12-weeks trial in healthy overweight Japanese male volunteersJ Oleo Sci.(2007)
    8. Nattokinase - Yang NC, Chou CW, Chen CY, Hwang KL, Yang YCCombined nattokinase with red yeast rice but not nattokinase alone has potent effects on blood lipids in human subjects with hyperlipidemia.Asia Pac J Clin Nutr.(2009)
    9. Ashwagandha - Raut AA, Rege NN, Tadvi FM, Solanki PV, Kene KR, Shirolkar SG, Pandey SN, Vaidya RA, Vaidya ABExploratory study to evaluate tolerability, safety, and activity of Ashwagandha (Withania somnifera) in healthy volunteersJ Ayurveda Integr Med.(2012 Jul)
    10. HMB - Richard B. Kreider, Maria Pontes Ferreira, Michael Greenwood, M. Wilson, Pamela Grindstaff, Steven Plisk, Jeff Reinardy, Edward Cantler, and Anthony L. AmaldaEffects of Calcium β-HMB Supplementation During Training on Markers of Catabolism, Body Composition, Strength and Sprint PerformanceJournal of Exercise Physiology.()
    11. Bushman's hat - Blom WA, Abrahamse SL, Bradford R, Duchateau GS, Theis W, Orsi A, Ward CL, Mela DJEffects of 15-d repeated consumption of Hoodia gordonii purified extract on safety, ad libitum energy intake, and body weight in healthy, overweight women: a randomized controlled trialAm J Clin Nutr.(2011 Nov)
    12. Korean black raspberry - Ji Eun Lee, Eunkyo Park, Jung Eun Lee, Joong Hyuck Auh, Hyung-Kyoon Choi, Jaehwi Lee, Soomuk Cho, Jung-Hyun KimEffects of a Rubus coreanus Miquel supplement on plasma antioxidant capacity in healthy Korean menNutr Res Pract.(2011 Oct)
    13. Black seed - Datau EA, Wardhana, Surachmanto EE, Pandelaki K, Langi JA, FiasEfficacy of Nigella sativa on serum free testosterone and metabolic disturbances in central obese maleActa Med Indones.(2010 Jul)
    14. Spirulina - Patricia V Torres-Duran, Aldo Ferreira-Hermosillo, Marco A Juarez-OropezaAntihyperlipemic and antihypertensive effects of Spirulina maxima in an open sample of Mexican population: a preliminary reportLipids Health Dis.(2007 Nov 26)
    15. Panax Ginseng (Korean Ginseng) - Meegun Hong, Yoon Hyeong Lee, Seungwoo Kim, Ki Tae Suk, Chang Seok Bang, Jai Hoon Yoon, Gwang Ho Baik, Dong Joon Kim, Myong Jo KimAnti-inflammatory and antifatigue effect of Korean Red Ginseng in patients with nonalcoholic fatty liver diseaseJ Ginseng Res.(2016 Jul)
    16. Bulbine Natalensis - Jennifer E Hofheins, Scott M Habowski, Tim N Ziegenfuss, and Hector L LopezShort term safety of bulbine natalensis supplementation in healthy menJISSN.()
    17. Ecdysteroids - Wilborn CD, Taylor LW, Campbell BI, Kerksick C, Rasmussen CJ, Greenwood M, Kreider RBEffects of methoxyisoflavone, ecdysterone, and sulfo-polysaccharide supplementation on training adaptations in resistance-trained malesJ Int Soc Sports Nutr.(2006 Dec 13)
    18. Chromium - Lai MHAntioxidant effects and insulin resistance improvement of chromium combined with vitamin C and e supplementation for type 2 diabetes mellitusJ Clin Biochem Nutr.(2008 Nov)
    19. Cocoa Extract - Di Renzo L, Rizzo M, Sarlo F, Colica C, Iacopino L, Domino E, Sergi D, De Lorenzo AEffects of dark chocolate in a population of normal weight obese women: a pilot studyEur Rev Med Pharmacol Sci.(2013 Aug)
    20. L-Carnitine - S Georgala, K H Schulpis, C Georgala, T MichasL-carnitine supplementation in patients with cystic acne on isotretinoin therapyJ Eur Acad Dermatol Venereol.(1999 Nov)
    21. Curcumin - Jazayeri-Tehrani SA, Rezayat SM, Mansouri S, Qorbani M, Alavian SM, Daneshi-Maskooni M, Hosseinzadeh-Attar MJNano-curcumin improves glucose indices, lipids, inflammation, and Nesfatin in overweight and obese patients with non-alcoholic fatty liver disease (NAFLD): a double-blind randomized placebo-controlled clinical trialNutr Metab (Lond).(2019 Jan 28)
    22. Rose Hip - Andersson U, Berger K, Högberg A, Landin-Olsson M, Holm CEffects of rose hip intake on risk markers of type 2 diabetes and cardiovascular disease: a randomized, double-blind, cross-over investigation in obese personsEur J Clin Nutr.(2012 May)
    23. Panax Ginseng (Korean Ginseng) - Yi-Ming Chen, I-Lin Wang, Shu Zhou, Tsung-Yu Tsai, Yen-Shuo Chiu, Wan-Chun ChiuSix weeks of Jilin ginseng root supplementation attenuates drop jump-related muscle injury markers in healthy female college studentsFood Funct.(2021 Mar 1)
    24. Tetradecyl Thioacetic Acid - Reidar J Pettersen, Mohamed Salem, Jon Skorve, Rune J Ulvik, Rolf K Berge, Jan Erik NordrehaugPharmacology and safety of tetradecylthioacetic acid (TTA): phase-1 studyJ Cardiovasc Pharmacol.(2008 Apr)
    25. L-Carnitine - Salvatore Benvenga, Antonino Amato, Menotti Calvani, Francesco TrimarchiEffects of carnitine on thyroid hormone actionAnn N Y Acad Sci.(2004 Nov)
    26. Citrulline - Paul Hwang, Flor E Morales Marroquín, Josh Gann, Tom Andre, Sarah McKinley-Barnard, Caelin Kim, Masahiko Morita, Darryn S WilloughbyEight weeks of resistance training in conjunction with glutathione and L-Citrulline supplementation increases lean mass and has no adverse effects on blood clinical safety markers in resistance-trained malesJ Int Soc Sports Nutr.(2018 Jun 27)
    27. Lactobacillus Reuteri - Jones ML, Martoni CJ, Di Pietro E, Simon RR, Prakash SEvaluation of clinical safety and tolerance of a Lactobacillus reuteri NCIMB 30242 supplement capsule: a randomized control trialRegul Toxicol Pharmacol.(2012 Jul)
    28. Vitamin E - P M Farrell, J G BieriMegavitamin E supplementation in manAm J Clin Nutr.(1975 Dec)
    29. Kefir - Ali Kudret Adiloğlu, Nurettin Gönülateş, Mehmet Işler, Altuğ Senol[The effect of kefir consumption on human immune system: a cytokine study]Mikrobiyol Bul.(2013 Apr)
    30. Melatonin - Gonciarz M, Bielański W, Partyka R, Brzozowski T, Konturek PC, Eszyk J, Celiński K, Reiter RJ, Konturek SJPlasma insulin, leptin, adiponectin, resistin, ghrelin, and melatonin in nonalcoholic steatohepatitis patients treated with melatoninJ Pineal Res.(2012 Jun 13)
    31. Red Clover Extract - Baber RJ, Templeman C, Morton T, Kelly GE, West LRandomized placebo-controlled trial of an isoflavone supplement and menopausal symptoms in womenClimacteric.(1999 Jun)
    32. Kefir - Ezgi Bellikci-Koyu, Banu Pınar Sarer-Yurekli, Yakut Akyon, Fadime Aydin-Kose, Cem Karagozlu, Ahmet Gokhan Ozgen, Annika Brinkmann, Andreas Nitsche, Koray Ergunay, Engin Yilmaz, Zehra BuyuktuncerEffects of Regular Kefir Consumption on Gut Microbiota in Patients with Metabolic Syndrome: A Parallel-Group, Randomized, Controlled StudyNutrients.(2019 Sep 4)
    33. Curcumin - Na LX, Li Y, Pan HZ, Zhou XL, Sun DJ, Meng M, Li XX, Sun CHCurcuminoids exert glucose-lowering effect in type 2 diabetes by decreasing serum free fatty acids: a double-blind, placebo-controlled trialMol Nutr Food Res.(2013 Sep)
    34. S-adenosylmethionine - Medici V, Virata MC, Peerson JM, Stabler SP, French SW, Gregory JF 3rd, Albanese A, Bowlus CL, Devaraj S, Panacek EA, Richards JR, Halsted CHS-adenosyl-L-methionine treatment for alcoholic liver disease: a double-blinded, randomized, placebo-controlled trialAlcohol Clin Exp Res.(2011 Nov)
    35. L-Carnitine - Alavinejad P, et alEvaluation of L-Carnitine Efficacy in the Treatment of Non-Alcoholic Fatty Liver Disease among Diabetic Patients: A Randomized Double Blind Pilot StudyJ Gastroenterol Hepatol.()
    36. Vitamin D - David D Chandy, Jahnavi Kare, Shakal N Singh, Anjoo Agarwal, Vinita Das, Urmila Singh, V Ramesh, Vijayalakshmi BhatiaEffect of vitamin D supplementation, directly or via breast milk for term infants, on serum 25 hydroxyvitamin D and related biochemistry, and propensity to infection: a randomised placebo-controlled trialBr J Nutr.(2016 Jul)
    37. Rose Hip - Nagatomo A, Nishida N, Fukuhara I, Noro A, Kozai Y, Sato H, Matsuura YDaily intake of rosehip extract decreases abdominal visceral fat in preobese subjects: a randomized, double-blind, placebo-controlled clinical trialDiabetes Metab Syndr Obes.(2015 Mar 6)
    38. Kefir - GÖLÜNÜK, S et alEffects of traditional fermented beverages on some blood parameters in aerobic exercises.Biomedical Research.()
    39. Coenzyme Q10 - Serag H, El Wakeel L, Adly ACoenzyme Q10 administration has no effect on sICAM-1 and metabolic parameters of pediatrics with type 1 diabetes mellitusInt J Vitam Nutr Res.(2020 Jan 16)
    40. L-Carnitine - Esmaeil Yousefi Rad, Elham Eslampour, Ebrahim Falahi, Mahnaz Mardani, Azita Hekmatdoost, Omid Asbaghi, Somayeh SabooriEffects of carnitine supplementation on liver aminotransferase enzymes: A systematic review and meta-analysis of randomized controlled clinical trialsIndian J Gastroenterol.(2019 Dec)
    41. Reishi - Wachtel-Galor S, Tomlinson B, Benzie IFGanoderma lucidum ("Lingzhi"), a Chinese medicinal mushroom: biomarker responses in a controlled human supplementation studyBr J Nutr.(2004 Feb)
    42. Astaxanthin - Tominaga K, Hongo N, Fujishita M, Takahashi Y, Adachi YProtective effects of astaxanthin on skin deteriorationJ Clin Biochem Nutr.(2017 Jul)
    43. Kefir - Ghizi ACdS et alKefir improves blood parameters and reduces cardiovascular risks in patients with metabolic syndromePharmaNutrition.()
    44. Curcumin - Funamoto M, Sunagawa Y, Katanasaka Y, Miyazaki Y, Imaizumi A, Kakeya H, Yamakage H, Satoh-Asahara N, Komiyama M, Wada H, Hasegawa K, Morimoto THighly absorptive curcumin reduces serum atherosclerotic low-density lipoprotein levels in patients with mild COPDInt J Chron Obstruct Pulmon Dis.(2016 Aug 26)
    45. S-adenosylmethionine - Thompson MA, Bauer BA, Loehrer LL, Cha SS, Mandrekar JN, Sood A, Wahner-Roedler DLDietary supplement S-adenosyl-L-methionine (AdoMet) effects on plasma homocysteine levels in healthy human subjects: a double-blind, placebo-controlled, randomized clinical trialJ Altern Complement Med.(2009 May)
    46. Creatine - Manjarrez-Montes de Oca R, Farfán-González F, Camarillo-Romero S, Tlatempa-Sotelo P, Francisco-Argüelles C, Kormanowski A, González-Gallego J, Alvear-Ordenes IEffects of creatine supplementation in taekwondo practitionersNutr Hosp.(2013 Mar-Apr)
    47. Citrulline - Sureda A, Cordova A, Ferrer MD, Tauler P, Perez G, Tur JA, Pons AEffects of L-citrulline oral supplementation on polymorphonuclear neutrophils oxidative burst and nitric oxide production after exerciseFree Radic Res.(2009 Sep)
    48. Astaxanthin - Nakagawa K, Kiko T, Miyazawa T, Carpentero Burdeos G, Kimura F, Satoh A, Miyazawa TAntioxidant effect of astaxanthin on phospholipid peroxidation in human erythrocytesBr J Nutr.(2011 Jun)
    49. Conjugated Linoleic Acid - Gaullier JM, Halse J, Høye K, Kristiansen K, Fagertun H, Vik H, Gudmundsen OSupplementation with conjugated linoleic acid for 24 months is well tolerated by and reduces body fat mass in healthy, overweight humansJ Nutr.(2005 Apr)
    50. L-Carnitine - Jee Hyun An, Yoon Jung Kim, Kyeong Jin Kim, Sun Hwa Kim, Nam Hoon Kim, Hee Young Kim, Nan Hee Kim, Kyung Mook Choi, Sei Hyun Baik, Dong Seop Choi, Sin Gon KimL-carnitine supplementation for the management of fatigue in patients with hypothyroidism on levothyroxine treatment: a randomized, double-blind, placebo-controlled trialEndocr J.(2016 Oct 29)
    51. L-Carnitine - Malaguarnera M, Bella R, Vacante M, Giordano M, Malaguarnera G, Gargante MP, Motta M, Mistretta A, Rampello L, Pennisi GAcetyl-L-carnitine reduces depression and improves quality of life in patients with minimal hepatic encephalopathyScand J Gastroenterol.(2011 Jun)
    52. Inositol - Joseph Levine, Mirtha Gonsalves, Izak Babur, Shaul Stier, Avner Elizur, Ora Kofman, R. H. BelmakerInositol 6 g daily may be effective in depression but not in schizophreniaHuman Psychopharmacology: Clinical and Experimental.()
    53. Creatine - Groeneveld GJ, Veldink JH, van der Tweel I, Kalmijn S, Beijer C, de Visser M, Wokke JH, Franssen H, van den Berg LHA randomized sequential trial of creatine in amyotrophic lateral sclerosisAnn Neurol.(2003 Apr)
    54. Betaine - Schwab U, Alfthan G, Aro A, Uusitupa MLong-term effect of betaine on risk factors associated with the metabolic syndrome in healthy subjectsEur J Clin Nutr.(2011 Jan)
    55. Curcumin - Chuengsamarn S, Rattanamongkolgul S, Phonrat B, Tungtrongchitr R, Jirawatnotai SReduction of atherogenic risk in patients with type 2 diabetes by curcuminoid extract: a randomized controlled trialJ Nutr Biochem.(2014 Feb)
    56. TUDCA - Crosignani A, Budillon G, Cimino L, Del Vecchio Blanco C, Loguercio C, Ideo G, Raimondo G, Stabilini R, Podda MTauroursodeoxycholic acid for the treatment of HCV-related chronic hepatitis: a multicenter placebo-controlled studyHepatogastroenterology.(1998 Sep-Oct)
    57. Black seed - Qidwai W, Hamza HB, Qureshi R, Gilani AEffectiveness, safety, and tolerability of powdered Nigella sativa (kalonji) seed in capsules on serum lipid levels, blood sugar, blood pressure, and body weight in adults: results of a randomized, double-blind controlled trialJ Altern Complement Med.(2009 Jun)
    58. Astaxanthin - Spiller GA, Dewell ASafety of an astaxanthin-rich Haematococcus pluvialis algal extract: a randomized clinical trialJ Med Food.(2003 Spring)
    59. Saffron - Mansoori P, et alA Randomized, Double-blind, Placebo - controlled Study of Safety of the Adjunctive Saffron on Sexual Dysfunction Induced by a Selective Serotonin Reuptake InhibitorJ Med Plant .()
    60. Kava - Gastpar M, Klimm HDTreatment of anxiety, tension and restlessness states with Kava special extract WS 1490 in general practice: a randomized placebo-controlled double-blind multicenter trialPhytomedicine.(2003 Nov)
    61. Olive Leaf Extract - de Bock M, Derraik JG, Brennan CM, Biggs JB, Morgan PE, Hodgkinson SC, Hofman PL, Cutfield WSOlive (Olea europaea L.) Leaf Polyphenols Improve Insulin Sensitivity in Middle-Aged Overweight Men: A Randomized, Placebo-Controlled, Crossover TrialPLoS One.(2013)
    62. TUDCA - Panella C, Ierardi E, De Marco MF, Barone M, Guglielmi FW, Polimeno L, Francavilla ADoes tauroursodeoxycholic acid (TUDCA) treatment increase hepatocyte proliferation in patients with chronic liver diseaseItal J Gastroenterol.(1995 Jun)
    63. Curcumin - Panahi Y, Khalili N, Sahebi E, Namazi S, Simental-Mendía LE, Majeed M, Sahebkar AEffects of Curcuminoids Plus Piperine on Glycemic, Hepatic and Inflammatory Biomarkers in Patients with Type 2 Diabetes Mellitus: A Randomized Double-Blind Placebo-Controlled TrialDrug Res (Stuttg).(2018 Jul)
    64. Curcumin - Yang H, Xu W, Zhou Z, Liu J, Li X, Chen L, Weng J, Yu ZCurcumin attenuates urinary excretion of albumin in type II diabetic patients with enhancing nuclear factor erythroid-derived 2-like 2 (Nrf2) system and repressing inflammatory signaling efficaciesExp Clin Endocrinol Diabetes.(2015 Jun)
    65. L-Carnitine - Bruls Y, et alCarnitine supplementation improves metabolic flexibility and skeletal muscle acetylcarnitine formation in volunteers with impaired glucose tolerance: A randomised controlled trialEBioMedicine.()
    66. Bitter Cucumber - Rahbar AR, Nabipour IThe hypolipidemic effect of Citrullus colocynthis on patients with hyperlipidemiaPak J Biol Sci.(2010 Dec 15)
    67. Vitamin E - T Hasegawa, M Yoneda, K Nakamura, I Makino, A TeranoPlasma transforming growth factor-beta1 level and efficacy of alpha-tocopherol in patients with non-alcoholic steatohepatitis: a pilot studyAliment Pharmacol Ther.(2001 Oct)
    68. Curcumin - Navekar R, Rafraf M, Ghaffari A, Asghari-Jafarabadi M, Khoshbaten MTurmeric Supplementation Improves Serum Glucose Indices and Leptin Levels in Patients with Nonalcoholic Fatty Liver DiseasesJ Am Coll Nutr.(2017 May-Jun)
    69. Bitter Cucumber - Huseini HF, Darvishzadeh F, Heshmat R, Jafariazar Z, Raza M, Larijani BThe clinical investigation of Citrullus colocynthis (L.) schrad fruit in treatment of Type II diabetic patients: a randomized, double blind, placebo-controlled clinical trialPhytother Res.(2009 Aug)
    70. Astaxanthin - Coombes JS, Sharman JE, Fassett RGAstaxanthin has no effect on arterial stiffness, oxidative stress, or inflammation in renal transplant recipients: a randomized controlled trial (the XANTHIN trial)Am J Clin Nutr.(2016 Jan)
    71. Tetradecyl Thioacetic Acid - Fredriksen J, Ueland T, Dyrøy E, Halvorsen B, Melby K, Melbye L, Skalhegg BS, Bohov P, Skorve J, Berge RK, Aukrust P, Frøland SSLipid-lowering and anti-inflammatory effects of tetradecylthioacetic acid in HIV-infected patients on highly active antiretroviral therapyEur J Clin Invest.(2004 Oct)
    72. L-Carnitine - Mohamad Hosein Somi, Ebrahim Fatahi, Jafar Panahi, Mohamad Reza Havasian, Arezo JudakiData from a randomized and controlled trial of LCarnitine prescription for the treatment for Non- Alcoholic Fatty Liver DiseaseBioinformation.(2014 Sep 30)
    73. Vitamin C - Mason SA, Rasmussen B, van Loon LJC, Salmon J, Wadley GDAscorbic acid supplementation improves postprandial glycaemic control and blood pressure in individuals with type 2 diabetes: Findings of a randomized cross-over trialDiabetes Obes Metab.(2019 Mar)
    74. Conjugated Linoleic Acid - Whigham LD, O'Shea M, Mohede IC, Walaski HP, Atkinson RLSafety profile of conjugated linoleic acid in a 12-month trial in obese humansFood Chem Toxicol.(2004 Oct)
    75. Spirulina - Elias E Mazokopakis, Maria G Papadomanolaki, Andreas A Fousteris, Dimitrios A Kotsiris, Ioannis M Lampadakis, Emmanuel S GanotakisThe hepatoprotective and hypolipidemic effects of Spirulina ( Arthrospira platensis) supplementation in a Cretan population with non-alcoholic fatty liver disease: a prospective pilot studyAnn Gastroenterol.(2014)
    76. Vitamin E - Miwa Kawanaka, Sabina Mahmood, Gouichi Niiyama, Akiyoshi Izumi, Ayumi Kamei, Hideji Ikeda, Mitsuhiko Suehiro, Kazumi Togawa, Takayo Sasagawa, Misako Okita, Hajime Nakamura, Junji Yodoi, Gotaro YamadaControl of oxidative stress and reduction in biochemical markers by Vitamin E treatment in patients with nonalcoholic steatohepatitis: a pilot studyHepatology Research.()
    77. Creatine - Schilling BK, Stone MH, Utter A, Kearney JT, Johnson M, Coglianese R, Smith L, O'Bryant HS, Fry AC, Starks M, Keith R, Stone MECreatine supplementation and health variables: a retrospective studyMed Sci Sports Exerc.(2001 Feb)
    78. Garlic - K Rahman, D BillingtonDietary supplementation with aged garlic extract inhibits ADP-induced platelet aggregation in humansJ Nutr.(2000 Nov)
    79. Astaxanthin - Chen JT, Kotani KEffects of Astaxanthin on Liver and Leukocyte Parameters in Healthy Climacteric Women: Preliminary DataJ Med Food.(2017 Jul)
    80. Boron - Nielsen F, Penland JBoron supplementation of peri‐menopausal women affects boron metabolism and indices associated with macromineral metabolism, hormonal status and immune functionJ Trace Elem Med Biol.()
    81. Curcumin - T Krishnareddy N, Thomas JV, Nair SS, N Mulakal J, Maliakel BP, Krishnakumar IMA Novel Curcumin-Galactomannoside Complex Delivery System Improves Hepatic Function Markers in Chronic Alcoholics: A Double-Blinded, randomized, Placebo-Controlled StudyBiomed Res Int.(2018 Sep 23)
    82. Rose Hip - Kharazmi A, Winther KRose hip inhibits chemotaxis and chemiluminescence of human peripheral blood neutrophils in vitro and reduces certain inflammatory parameters in vivoInflammopharmacology.(1999)
    83. Vitamin E - Sumida Y, Naito Y, Tanaka S, Sakai K, Inada Y, Taketani H, Kanemasa K, Yasui K, Itoh Y, Okanoue T, Yoshikawa TLong-term (>=2 yr) efficacy of vitamin E for non-alcoholic steatohepatitisHepatogastroenterology.(2013 Sep)
    84. Conjugated Linoleic Acid - Smedman A, Vessby B, Basu SIsomer-specific effects of conjugated linoleic acid on lipid peroxidation in humans: regulation by alpha-tocopherol and cyclo-oxygenase-2 inhibitorClin Sci (Lond).(2004 Jan)
    85. King of Bitters - Calabrese C, Berman SH, Babish JG, Ma X, Shinto L, Dorr M, Wells K, Wenner CA, Standish LJA phase I trial of andrographolide in HIV positive patients and normal volunteersPhytother Res.(2000 Aug)
    86. Garlic - Sobenin IA, Andrianova IV, Demidova ON, Gorchakova T, Orekhov ANLipid-lowering effects of time-released garlic powder tablets in double-blinded placebo-controlled randomized studyJ Atheroscler Thromb.(2008 Dec)
    87. Saffron - Motahareh Hasani, Mahsa Malekahmadi, Gholamreza Rezamand, M Dulce Estêvão, Ana Beatriz Pizarro, Hafez Heydari, Wong Chun Hoong, Omar Ahnaf Arafah, Abdul Rahman Riad Barakeh, Areej Rahman, Mona Saud K Alrashidi, Ahmed Abu-ZaidEffect of saffron supplementation on liver enzymes: A systematic review and meta-analysis of randomized controlled trialsDiabetes Metab Syndr.(2021 Oct 12)
    88. Spirulina - Ferreira-Hermosillo A, Torres-Duran PV, Juarez-Oropeza MAHepatoprotective effects of Spirulina maxima in patients with non-alcoholic fatty liver disease: a case seriesJ Med Case Rep.(2010 Apr 7)
    89. Vitamin E - Sanyal AJ, Chalasani N, Kowdley KV, McCullough A, Diehl AM, Bass NM, Neuschwander-Tetri BA, Lavine JE, Tonascia J, Unalp A, Van Natta M, Clark J, Brunt EM, Kleiner DE, Hoofnagle JH, Robuck PR, NASH CRNPioglitazone, vitamin E, or placebo for nonalcoholic steatohepatitisN Engl J Med.(2010 May 6)
    90. Curcumin - Saeede Saadati, Behzad Hatami, Zahra Yari, Mohammad Amin Shahrbaf, Sareh Eghtesad, Asieh Mansour, Hossein Poustchi, Mehdi Hedayati, Morteza Aghajanpoor-Pasha, Amir Sadeghi, Azita HekmatdoostThe effects of curcumin supplementation on liver enzymes, lipid profile, glucose homeostasis, and hepatic steatosis and fibrosis in patients with non-alcoholic fatty liver diseaseEur J Clin Nutr.(2019 Mar)
    91. Terminalia Arjuna - S Dwivedi, R JauhariBeneficial effects of Terminalia arjuna in coronary artery diseaseIndian Heart J.(Sep-Oct 1997)
    92. PQQ - Harris CB, Chowanadisai W, Mishchuk DO, Satre MA, Slupsky CM, Rucker RBDietary pyrroloquinoline quinone (PQQ) alters indicators of inflammation and mitochondrial-related metabolism in human subjectsJ Nutr Biochem.(2013 Dec)
    93. Curcumin - Maithili Karpaga Selvi N, Sridhar MG, Swaminathan RP, Sripradha REfficacy of Turmeric as Adjuvant Therapy in Type 2 Diabetic PatientsIndian J Clin Biochem.(2015 Apr)
    94. Creatine - Tarnopolsky MA, Mahoney DJ, Vajsar J, Rodriguez C, Doherty TJ, Roy BD, Biggar DCreatine monohydrate enhances strength and body composition in Duchenne muscular dystrophyNeurology.(2004 May 25)
    95. Eleuthero - Kuo J, Chen KW, Cheng IS, Tsai PH, Lu YJ, Lee NYThe effect of eight weeks of supplementation with Eleutherococcus senticosus on endurance capacity and metabolism in humanChin J Physiol.(2010 Apr 30)
    96. Ketogenic Diet - Athinarayanan SJ, Adams RN, Hallberg SJ, McKenzie AL, Bhanpuri NH, Campbell WW, Volek JS, Phinney SD, McCarter JPLong-Term Effects of a Novel Continuous Remote Care Intervention Including Nutritional Ketosis for the Management of Type 2 Diabetes: A 2-Year Non-randomized Clinical TrialFront Endocrinol (Lausanne).(2019 Jun 5)
    97. Vitamin E - Kitagawa M, Mino MEffects of elevated d-alpha(RRR)-tocopherol dosage in manJ Nutr Sci Vitaminol (Tokyo).(1989 Apr)
    98. Dill - Mansouri M, Nayebi N, Keshtkar A, Hasani-Ranjbar S, Taheri E, Larijani BThe effect of 12 weeks Anethum graveolens (dill) on metabolic markers in patients with metabolic syndrome; a randomized double blind controlled trialDaru.(2012 Oct 4)
    99. Jiaogulan - Chou SC, Chen KW, Hwang JS, Lu WT, Chu YY, Lin JD, Chang HJ, See LCThe add-on effects of Gynostemma pentaphyllum on nonalcoholic fatty liver diseaseAltern Ther Health Med.(2006 May-Jun)
    100. Saffron - Milajerdi A, et alThe effect of saffron (Crocus sativus L.) hydro-alcoholic extract on liver and renal functions in type 2 diabetic patients: A double-blinded randomized and placebo control trialJournal of Nutrition & Intermediary Metabolism.()
    101. Black Cohosh - Ahmed Nasr, Hanan NafehInfluence of black cohosh (Cimicifuga racemosa) use by postmenopausal women on total hepatic perfusion and liver functionsFertil Steril.(2009 Nov)
    102. Curcumin - Panda SK, Nirvanashetty S, Parachur VA, Mohanty N, Swain TA Randomized, Double Blind, Placebo Controlled, Parallel-Group Study to Evaluate the Safety and Efficacy of Curene® versus Placebo in Reducing Symptoms of Knee OABiomed Res Int.(2018 Oct 25)
    103. Tribulus Terrestris - GamalEl Din SF, Abdel Salam MA, Mohamed MS, Ahmed AR, Motawaa AT, Saadeldin OA, Elnabarway RRTribulus terrestris versus placebo in the treatment of erectile dysfunction and lower urinary tract symptoms in patients with late-onset hypogonadism: A placebo-controlled studyUrologia.(2018 Sep 25)
    104. Spirulina - Reza Bagheri, Raoof Negaresh, Mohamad S Motevalli, Alexei Wong, Damoon Ashtary-Larky, Mehdi Kargarfard, Amir RashidlamirSpirulina supplementation during gradual weight loss in competitive wrestlersBr J Nutr.(2021 Mar 15)
    105. Resveratrol - Timmers S, Konings E, Bilet L, Houtkooper RH, van de Weijer T, Goossens GH, Hoeks J, van der Krieken S, Ryu D, Kersten S, Moonen-Kornips E, Hesselink MK, Kunz I, Schrauwen-Hinderling VB, Blaak EE, Auwerx J, Schrauwen PCalorie restriction-like effects of 30 days of resveratrol supplementation on energy metabolism and metabolic profile in obese humansCell Metab.(2011 Nov 2)
    106. Perilla - Minggang Wei, Peihua Xiong, Ling Zhang, Mei Fei, Aiping Chen, Fengling LiPerilla oil and exercise decrease expressions of tumor necrosis factor-alpha, plasminogen activator inhibitor-1 and highly sensitive C-reactive protein in patients with hyperlipidemiaJ Tradit Chin Med.(2013 Apr)
    107. Roselle - Gurrola-Díaz CM, García-López PM, Sánchez-Enríquez S, Troyo-Sanromán R, Andrade-González I, Gómez-Leyva JFEffects of Hibiscus sabdariffa extract powder and preventive treatment (diet) on the lipid profiles of patients with metabolic syndrome (MeSy)Phytomedicine.(2010 Jun)
    108. L-Carnitine - Malaguarnera M, Gargante MP, Russo C, Antic T, Vacante M, Malaguarnera M, Avitabile T, Li Volti G, Galvano FL-carnitine supplementation to diet: a new tool in treatment of nonalcoholic steatohepatitis--a randomized and controlled clinical trialAm J Gastroenterol.(2010 Jun)
    109. Leucine - Ispoglou T, King RF, Polman RC, Zanker CDaily L-leucine supplementation in novice trainees during a 12-week weight training programInt J Sports Physiol Perform.(2011 Mar)
    110. Creatine - Mayhew DL, Mayhew JL, Ware JSEffects of long-term creatine supplementation on liver and kidney functions in American college football playersInt J Sport Nutr Exerc Metab.(2002 Dec)
    111. Hesperidin - Miwa Y, Mitsuzumi H, Sunayama T, Yamada M, Okada K, Kubota M, Chaen H, Mishima Y, Kibata MGlucosyl hesperidin lowers serum triglyceride level in hypertriglyceridemic subjects through the improvement of very low-density lipoprotein metabolic abnormalityJ Nutr Sci Vitaminol (Tokyo).(2005 Dec)
    112. Conjugated Linoleic Acid - Venkatramanan S, Joseph SV, Chouinard PY, Jacques H, Farnworth ER, Jones PJMilk enriched with conjugated linoleic acid fails to alter blood lipids or body composition in moderately overweight, borderline hyperlipidemic individualsJ Am Coll Nutr.(2010 Apr)
    113. Creatine - Tarnopolsky M, Mahoney D, Thompson T, Naylor H, Doherty TJCreatine monohydrate supplementation does not increase muscle strength, lean body mass, or muscle phosphocreatine in patients with myotonic dystrophy type 1Muscle Nerve.(2004 Jan)
    114. Black seed - Dehkordi FR, Kamkhah AFAntihypertensive effect of Nigella sativa seed extract in patients with mild hypertensionFundam Clin Pharmacol.(2008 Aug)
    115. Vitamin E - Meydani SN, Meydani M, Rall LC, Morrow F, Blumberg JBAssessment of the safety of high-dose, short-term supplementation with vitamin E in healthy older adultsAm J Clin Nutr.(1994 Nov)
    116. TUDCA - Invernizzi P, Setchell KD, Crosignani A, Battezzati PM, Larghi A, O'Connell NC, Podda MDifferences in the metabolism and disposition of ursodeoxycholic acid and of its taurine-conjugated species in patients with primary biliary cirrhosisHepatology.(1999 Feb)
    117. Fish Oil - Nobili V, Bedogni G, Alisi A, Pietrobattista A, Risé P, Galli C, Agostoni CDocosahexaenoic acid supplementation decreases liver fat content in children with non-alcoholic fatty liver disease: double-blind randomised controlled clinical trialArch Dis Child.(2011 Apr)
    118. Phosphatidylserine - Kato-Kataoka A, Sakai M, Ebina R, Nonaka C, Asano T, Miyamori TSoybean-derived phosphatidylserine improves memory function of the elderly Japanese subjects with memory complaintsJ Clin Biochem Nutr.(2010 Nov)
    119. Glutamine - Galera SC, Fechine FV, Teixeira MJ, Coelho ZC, de Vasconcelos RC, de Vasconcelos PRThe safety of oral use of L-glutamine in middle-aged and elderly individualsNutrition.(2010 Apr)
    120. Betaine - Schwab U, Törrönen A, Toppinen L, Alfthan G, Saarinen M, Aro A, Uusitupa MBetaine supplementation decreases plasma homocysteine concentrations but does not affect body weight, body composition, or resting energy expenditure in human subjectsAm J Clin Nutr.(2002 Nov)
    121. Curcumin - Kim SW, Ha KC, Choi EK, Jung SY, Kim MG, Kwon DY, Yang HJ, Kim MJ, Kang HJ, Back HI, Kim SY, Park SH, Baek HY, Kim YJ, Lee JY, Chae SWThe effectiveness of fermented turmeric powder in subjects with elevated alanine transaminase levels: a randomised controlled studyBMC Complement Altern Med.(2013 Mar 8)
    122. Theanine - Shinsuke Hidese, Miho Ota, Chisato Wakabayashi, Takamasa Noda, Hayato Ozawa, Tsutomu Okubo, Hiroshi KunugiEffects of chronic l-theanine administration in patients with major depressive disorder: an open-label studyActa Neuropsychiatr.(2017 Apr)
    123. Black seed - Eman Mahmoud Fathy Barakat, Lamia Mohamed El Wakeel, Radwa Samir HagagEffects of Nigella sativa on outcome of hepatitis C in EgyptWorld J Gastroenterol.(2013 Apr 28)
    124. Creatine - Roy BD, de Beer J, Harvey D, Tarnopolsky MACreatine monohydrate supplementation does not improve functional recovery after total knee arthroplastyArch Phys Med Rehabil.(2005 Jul)
    125. Lactobacillus Reuteri - Jones ML, Martoni CJ, Parent M, Prakash SCholesterol-lowering efficacy of a microencapsulated bile salt hydrolase-active Lactobacillus reuteri NCIMB 30242 yoghurt formulation in hypercholesterolaemic adultsBr J Nutr.(2012 May)
    126. Chromium - Yazaki Y, Faridi Z, Ma Y, Ali A, Northrup V, Njike VY, Liberti L, Katz DLA pilot study of chromium picolinate for weight lossJ Altern Complement Med.(2010 Mar)
    127. Astaxanthin - Kim JH, Chang MJ, Choi HD, Youn YK, Kim JT, Oh JM, Shin WGProtective effects of Haematococcus astaxanthin on oxidative stress in healthy smokersJ Med Food.(2011 Nov)
    128. Tetradecyl Thioacetic Acid - Løvås K, Røst TH, Skorve J, Ulvik RJ, Gudbrandsen OA, Bohov P, Wensaas AJ, Rustan AC, Berge RK, Husebye ESTetradecylthioacetic acid attenuates dyslipidaemia in male patients with type 2 diabetes mellitus, possibly by dual PPAR-alpha/delta activation and increased mitochondrial fatty acid oxidationDiabetes Obes Metab.(2009 Apr)
    129. HMB - Kreider RB, Ferreira M, Wilson M, Almada ALEffects of calcium beta-hydroxy-beta-methylbutyrate (HMB) supplementation during resistance-training on markers of catabolism, body composition and strengthInt J Sports Med.(1999 Nov)
    130. Kava - Sarris J, Kavanagh DJ, Byrne G, Bone KM, Adams J, Deed GThe Kava Anxiety Depression Spectrum Study (KADSS): a randomized, placebo-controlled crossover trial using an aqueous extract of Piper methysticumPsychopharmacology (Berl).(2009 Aug)
    131. Eleuthero - Lee YJ, Chung HY, Kwak HK, Yoon SThe effects of A. senticosus supplementation on serum lipid profiles, biomarkers of oxidative stress, and lymphocyte DNA damage in postmenopausal womenBiochem Biophys Res Commun.(2008 Oct 10)
    132. Curcumin - Kocher A, Bohnert L, Schiborr C, Frank JHighly bioavailable micellar curcuminoids accumulate in blood, are safe and do not reduce blood lipids and inflammation markers in moderately hyperlipidemic individualsMol Nutr Food Res.(2016 Jul)
    133. Vitamin E - Meydani SN, Barklund MP, Liu S, Meydani M, Miller RA, Cannon JG, Morrow FD, Rocklin R, Blumberg JBVitamin E supplementation enhances cell-mediated immunity in healthy elderly subjectsAm J Clin Nutr.(1990 Sep)
    134. Curcumin - Chainani-Wu N, Madden E, Lozada-Nur F, Silverman S JrHigh-dose curcuminoids are efficacious in the reduction in symptoms and signs of oral lichen planusJ Am Acad Dermatol.(2012 May)
    135. Saffron - Armaghan Moravej Aleali, Reza Amani, Hajieh Shahbazian, Frough Namjooyan, Seyed Mahmoud Latifi, Bahman CheraghianThe effect of hydroalcoholic Saffron (Crocus sativus L.) extract on fasting plasma glucose, HbA1c, lipid profile, liver, and renal function tests in patients with type 2 diabetes mellitus: A randomized double-blind clinical trialPhytother Res.(2019 Jun)
    136. Betaine - Sandeep Mukherjee, Tamara Bernard, Kusum Kharbanda, Anthony J. Barak, Michael F. Sorrell, Dean J. TumaImpact of Betaine on Hepatic Fibrosis and Homocysteine in Nonalcoholic Steatohepatitis - A Prospective, Cohort StudyThe Open Translational Medicine Journal.()
    137. Saffron - Kianbakht S, Ghazavi AImmunomodulatory effects of saffron: a randomized double-blind placebo-controlled clinical trialPhytother Res.(2011 Dec)
    138. Artichoke Extract - Englisch W, Beckers C, Unkauf M, Ruepp M, Zinserling VEfficacy of Artichoke dry extract in patients with hyperlipoproteinemiaArzneimittelforschung.(2000 Mar)
    139. Chromium - Campbell WW, Joseph LJ, Ostlund RE Jr, Anderson RA, Farrell PA, Evans WJResistive training and chromium picolinate: effects on inositols and liver and kidney functions in older adultsInt J Sport Nutr Exerc Metab.(2004 Aug)
    140. Cordyceps - Li Y, Xue WJ, Tian PX, Ding XM, Yan H, Pan XM, Feng XSClinical application of Cordyceps sinensis on immunosuppressive therapy in renal transplantationTransplant Proc.(2009 Jun)
    141. Spirulina - Gitte S Jensen, Cassandra Drapeau, Miki Lenninger, Kathleen F BensonClinical Safety of a High Dose of Phycocyanin-Enriched Aqueous Extract from Arthrospira (Spirulina) platensis: Results from a Randomized, Double-Blind, Placebo-Controlled Study with a Focus on Anticoagulant Activity and Platelet ActivationJ Med Food.(2016 Jul)
    142. Astaxanthin - Baralic I, Andjelkovic M, Djordjevic B, Dikic N, Radivojevic N, Suzin-Zivkovic V, Radojevic-Skodric S, Pejic SEffect of Astaxanthin Supplementation on Salivary IgA, Oxidative Stress, and Inflammation in Young Soccer PlayersEvid Based Complement Alternat Med.(2015)
    143. Lactobacillus Reuteri - Wolf BW, Wheeler KB, Ataya DG, Garleb KASafety and tolerance of Lactobacillus reuteri supplementation to a population infected with the human immunodeficiency virusFood Chem Toxicol.(1998 Dec)
    144. Astaxanthin - Saito M, Yoshida K, Saito W, Fujiya A, Ohgami K, Kitaichi N, Tsukahara H, Ishida S, Ohno SAstaxanthin increases choroidal blood flow velocityGraefes Arch Clin Exp Ophthalmol.(2012 Feb)
    145. Royal Jelly - Hang Guo, Ai Saiga, Mikako Sato, Izumi Miyazawa, Makoto Shibata, Yoshihisa Takahata, Fumiki MorimatsuRoyal jelly supplementation improves lipoprotein metabolism in humansJ Nutr Sci Vitaminol (Tokyo).(2007 Aug)
    146. L-Carnitine - Eun Shil Hong, Eun Ky Kim, Seon Mee Kang, Ah Reum Khang, Sung Hee Choi, Kyong Soo Park, Hak Chul Jang, Soo LimEffect of carnitine-orotate complex on glucose metabolism and fatty liver: a double-blind, placebo-controlled studyJ Gastroenterol Hepatol.(2014)
    147. Ashwagandha - Ziegenfuss TN, Kedia AW, Sandrock JE, Raub BJ, Kerksick CM, Lopez HLEffects of an Aqueous Extract of Withania somnifera on Strength Training Adaptations and Recovery: The STAR TrialNutrients.(2018 Nov 20)
    148. S-adenosylmethionine - Santini D, Vincenzi B, Massacesi C, Picardi A, Gentilucci UV, Esposito V, Liuzzi G, La Cesa A, Rocci L, Marcucci F, Montesarchio V, Groeger AM, Bonsignori M, Tonini GS-adenosylmethionine (AdoMet) supplementation for treatment of chemotherapy-induced liver injuryAnticancer Res.(2003 Nov-Dec)
    149. Rhodiola Rosea - Shanely RA, Nieman DC, Zwetsloot KA, Knab AM, Imagita H, Luo B, Davis B, Zubeldia JMEvaluation of Rhodiola rosea supplementation on skeletal muscle damage and inflammation in runners following a competitive marathonBrain Behav Immun.(2014 Jul)
    150. Curcumin - Rahmani S, Asgary S, Askari G, Keshvari M, Hatamipour M, Feizi A, Sahebkar ATreatment of Non-alcoholic Fatty Liver Disease with Curcumin: A Randomized Placebo-controlled TrialPhytother Res.(2016 Sep)
    151. Whey Protein - Chitapanarux T, Tienboon P, Pojchamarnwiputh S, Leelarungrayub DOpen-labeled pilot study of cysteine-rich whey protein isolate supplementation for nonalcoholic steatohepatitis patientsJ Gastroenterol Hepatol.(2009 Jun)
    152. Black seed - Bin Sayeed MS, Asaduzzaman M, Morshed H, Hossain MM, Kadir MF, Rahman MRThe effect of Nigella sativa Linn. seed on memory, attention and cognition in healthy human volunteersJ Ethnopharmacol.(2013 Jul 30)
    153. Conjugated Linoleic Acid - Sato K, Shinohara N, Honma T, Ito J, Arai T, Nosaka N, Aoyama T, Tsuduki T, Ikeda IThe change in conjugated linoleic acid concentration in blood of Japanese fed a conjugated linoleic acid dietJ Nutr Sci Vitaminol (Tokyo).(2011)
    154. Saffron - Bentolhoda Mousavi, Seyedeh Zahra Bathaie, Farbod Fadai, Zabihollah Ashtari, Neda Ali Beigi, Sara Farhang, Sara Hashempour, Nasim Shahhamzei, Hamid HeidarzadehSafety evaluation of saffron stigma (Crocus sativus L.) aqueous extract and crocin in patients with schizophreniaAvicenna J Phytomed.(Sep-Oct 2015)
    155. DHEA - Wallace MB, Lim J, Cutler A, Bucci LEffects of dehydroepiandrosterone vs androstenedione supplementation in menMed Sci Sports Exerc.(1999 Dec)
    156. Curcumin - DiSilvestro RA, Joseph E, Zhao S, Bomser JDiverse effects of a low dose supplement of lipidated curcumin in healthy middle aged peopleNutr J.(2012 Sep 26)
    157. Vitamin E - Meydani SN, Meydani M, Blumberg JB, Leka LS, Pedrosa M, Diamond R, Schaefer EJAssessment of the safety of supplementation with different amounts of vitamin E in healthy older adultsAm J Clin Nutr.(1998 Aug)
    158. L-Carnitine - M R Rubin, J S Volek, A L Gómez, N A Ratamess, D N French, M J Sharman, W J KraemerSafety measures of L-carnitine L-tartrate supplementation in healthy menJ Strength Cond Res.(2001 Nov)
    159. Saffron - Fatemeh Ebrahimi, Naheed Aryaeian, Naseh Pahlavani, Davood Abbasi, Agha Fatemeh Hosseini, Soudabeh Fallah, Nariman Moradi, Iraj HeydariThe effect of saffron ( Crocus sativus L.) supplementation on blood pressure, and renal and liver function in patients with type 2 diabetes mellitus: A double-blinded, randomized clinical trialAvicenna J Phytomed.(Jul-Aug 2019)
    160. Betaine - Abdelmalek MF, Sanderson SO, Angulo P, Soldevila-Pico C, Liu C, Peter J, Keach J, Cave M, Chen T, McClain CJ, Lindor KDBetaine for nonalcoholic fatty liver disease: results of a randomized placebo-controlled trialHepatology.(2009 Dec)
    161. Betaine - Abdelmalek MF, Angulo P, Jorgensen RA, Sylvestre PB, Lindor KDBetaine, a promising new agent for patients with nonalcoholic steatohepatitis: results of a pilot studyAm J Gastroenterol.(2001 Sep)
    162. Green Coffee Extract - Watanabe T, Arai Y, Mitsui Y, Kusaura T, Okawa W, Kajihara Y, Saito IThe blood pressure-lowering effect and safety of chlorogenic acid from green coffee bean extract in essential hypertensionClin Exp Hypertens.(2006 Jul)
    163. L-Carnitine - Jun-jie Zhang, Zhi-bing Wu, You-jin Cai, Bin Ke, Ying-juan Huang, Chao-ping Qiu, Yu-bing Yang, Lan-ying Shi, Jian QinL-carnitine ameliorated fasting-induced fatigue, hunger, and metabolic abnormalities in patients with metabolic syndrome: a randomized controlled studyNutr J.(2014 Nov 26)
    164. Tongkat Ali - Chen CK, Mohamad WM, Ooi FK, Ismail SB, Abdullah MR, George ASupplementation of Eurycoma longifolia Jack Extract for 6 Weeks Does Not Affect Urinary Testosterone: Epitestosterone Ratio, Liver and Renal Functions in Male Recreational Athletes.Int J Prev Med.(2014-Jun)
    165. Curcumin - Dehzad MJ, Ghalandari H, Amini MR, Askarpour MEffects of curcumin/turmeric supplementation on liver function in adults: A GRADE-assessed systematic review and dose-response meta-analysis of randomized controlled trials.Complement Ther Med.(2023-Jun)
    166. Curcumin - M H Ngu, M N Norhayati, Z Rosnani, M M ZulkifliCurcumin as adjuvant treatment in patients with non-alcoholic fatty liver (NAFLD) disease: A systematic review and meta-analysisComplement Ther Med.(2022 Sep)
    167. N-Acetylcysteine - Jia D, Guo S, Jia Z, Gao Z, You K, Gong J, Li SN-acetylcysteine in the Donor, Recipient, or Both Donor and Recipient in Liver Transplantation: A Systematic Review With Meta-analysis and Trial Sequential Analysis.Transplantation.(2023-May-08)
    168. Silymarin - Georgios Kalopitas, Christina Antza, Ioannis Doundoulakis, Antonis Siargkas, Elias Kouroumalis, Georgios Germanidis, Myrto Samara, Michail ChourdakisImpact of Silymarin in individuals with nonalcoholic fatty liver disease: A systematic review and meta-analysisNutrition.(2021 Mar)
    169. Silymarin - Zhong S, Fan Y, Yan Q, Fan X, Wu B, Han Y, Zhang Y, Chen Y, Zhang H, Niu JThe therapeutic effect of silymarin in the treatment of nonalcoholic fatty disease: A meta-analysis (PRISMA) of randomized control trialsMedicine (Baltimore).(2017 Dec)
    170. Silymarin - Kailin Yang, Junpeng Chen, Tianqing Zhang, Xiao Yuan, Anqi Ge, Shanshan Wang, Hao Xu, Liuting Zeng, Jinwen GeEfficacy and safety of dietary polyphenol supplementation in the treatment of non-alcoholic fatty liver disease: A systematic review and meta-analysisFront Immunol.(2022 Sep 9)
    171. Silymarin - Fakhri M, Fakheri H, Azadbakht M, Moosazadeh M, Yousefi SSEffect of Medicinal Plants and Natural Products on Liver Enzymes in Non-alcoholic Fatty Liver Patients in Iran: A Systematic Review and Meta-Analysis.Int J Prev Med.(2022)
    172. Silymarin - Saller R, Brignoli R, Melzer J, Meier RAn updated systematic review with meta-analysis for the clinical evidence of silymarin.Forsch Komplementmed.(2008-Feb)
    173. Silymarin - de Avelar CR, Pereira EM, de Farias Costa PR, de Jesus RP, de Oliveira LPMEffect of silymarin on biochemical indicators in patients with liver disease: Systematic review with meta-analysis.World J Gastroenterol.(2017-Jul-21)
    174. L-Carnitine - Liu A, Cai Y, Yuan Y, Liu M, Zhang Z, Xu Y, Jiao PEfficacy and safety of carnitine supplementation on NAFLD: a systematic review and meta-analysis.Syst Rev.(2023-Apr-29)
    175. L-Carnitine - Li Y, Xie Y, Qiu C, Yu B, Yang F, Cheng Y, Zhong W, Yuan JEffects of L-carnitine supplementation on glucolipid metabolism: a systematic review and meta-analysis.Food Funct.(2023-Mar-06)
    176. Mediterranean Diet - Asbaghi O, Choghakhori R, Ashtary-Larky D, Abbasnezhad AEffects of the Mediterranean diet on cardiovascular risk factors in non-alcoholic fatty liver disease patients: A systematic review and meta-analysis.Clin Nutr ESPEN.(2020 Mar 10)
    177. Mediterranean Diet - Akhlaghi M, Ghasemi-Nasab M, Riasatian MMediterranean diet for patients with non-alcoholic fatty liver disease, a systematic review and meta-analysis of observational and clinical investigations.J Diabetes Metab Disord.(2020-Jun)
    178. Mediterranean Diet - Veera Houttu, Susanne Csader, Max Nieuwdorp, Adriaan G Holleboom, Ursula SchwabDietary Interventions in Patients With Non-alcoholic Fatty Liver Disease: A Systematic Review and Meta-AnalysisFront Nutr.(2021 Jul 22)
    179. Mediterranean Diet - Haigh L, Kirk C, El Gendy K, Gallacher J, Errington L, Mathers JC, Anstee QMThe effectiveness and acceptability of Mediterranean diet and calorie restriction in non-alcoholic fatty liver disease (NAFLD): A systematic review and meta-analysis.Clin Nutr.(2022-Sep)
    180. Mediterranean Diet - Abbas Ali Sangouni, Shirin Hassani Zadeh, Hassan Mozaffari-Khosravi, Mahdieh HosseinzadehEffect of Mediterranean diet on liver enzymes: a systematic review and meta-analysis of randomised controlled trialsBr J Nutr.(2021 Jun 21)
    181. Mediterranean Diet - Wang X, Jin X, Li H, Zhang X, Chen X, Lu K, Chu CEffects of various interventions on non-alcoholic fatty liver disease (NAFLD): A systematic review and network meta-analysis.Front Pharmacol.(2023)
    182. Mediterranean Diet - Del Bo' C, Perna S, Allehdan S, Rafique A, Saad S, AlGhareeb F, Rondanelli M, Tayyem RF, Marino M, Martini D, Riso PDoes the Mediterranean Diet Have Any Effect on Lipid Profile, Central Obesity and Liver Enzymes in Non-Alcoholic Fatty Liver Disease (NAFLD) Subjects? A Systematic Review and Meta-Analysis of Randomized Control Trials.Nutrients.(2023-May-09)
    183. Coenzyme Q10 - Soleimani Damaneh M, Fatahi S, Aryaeian N, Bavi Behbahani HThe effect of coenzyme Q10 supplementation on liver enzymes: A systematic review and meta-analysis of randomized clinical trials.Food Sci Nutr.(2023-Sep)
    184. Coenzyme Q10 - Ardekani A, Tabrizi R, Maleki E, Bagheri Lankarani K, Heydari ST, Moradinazar M, Akbari MEffects of coenzyme Q10 supplementation on lipid profiles and liver enzymes of nonalcoholic fatty liver disease (NAFLD) patients: A systematic review and meta-analysis of randomized controlled trials.Food Sci Nutr.(2023-Jun)
    185. Silymarin - Yang Z, Zhuang L, Lu Y, Xu Q, Chen XEffects and tolerance of silymarin (milk thistle) in chronic hepatitis C virus infection patients: a meta-analysis of randomized controlled trials.Biomed Res Int.(2014)
    186. Resveratrol - Jingwen Zhou, Yidi Chen, Jun Yu, Tianci Li, Ziyu Lu, Yan Chen, Xiaolong Zhang, Fang YeThe efficacy of novel metabolic targeted agents and natural plant drugs for nonalcoholic fatty liver disease treatment: A PRISMA-compliant network meta-analysis of randomized controlled trialsMedicine (Baltimore).(2021 Mar 26)
    187. Resveratrol - Maryam Akbari, Omid Reza Tamtaji, Kamran B Lankarani, Reza Tabrizi, Ehsan Dadgostar, Neda Haghighat, Fariba Kolahdooz, Amir Ghaderi, Mohammad Ali Mansournia, Zatollah AsemiThe effects of resveratrol on lipid profiles and liver enzymes in patients with metabolic syndrome and related disorders: a systematic review and meta-analysis of randomized controlled trialsLipids Health Dis.(2020 Feb 17)
    188. Resveratrol - Karolina Jakubczyk, Karolina Skonieczna-Żydecka, Justyna Kałduńska, Ewa Stachowska, Izabela Gutowska, Katarzyna JandaEffects of Resveratrol Supplementation in Patients with Non-Alcoholic Fatty Liver Disease-A Meta-AnalysisNutrients.(2020 Aug 13)
    189. Resveratrol - Darand M, Farrokhzad A, Ghavami A, Hadi A, Karimi E, Fadel A, Askari GEffects of resveratrol supplementation on liver enzymes: A systematic review and meta-analysis of randomised controlled trials.Int J Clin Pract.(2021-Mar)
    190. Resveratrol - Zhang C, Yuan W, Fang J, Wang W, He P, Lei J, Wang CEfficacy of Resveratrol Supplementation against Non-Alcoholic Fatty Liver Disease: A Meta-Analysis of Placebo-Controlled Clinical Trials.PLoS One.(2016)
    191. Resveratrol - Elgebaly A, Radwan IA, AboElnas MM, Ibrahim HH, Eltoomy MF, Atta AA, Mesalam HA, Sayed AA, Othman AAResveratrol Supplementation in Patients with Non-Alcoholic Fatty Liver Disease: Systematic Review and Meta-analysis.J Gastrointestin Liver Dis.(2017-Mar)
    192. Resveratrol - Sahar Rafiee, Hamed Mohammadi, Abed Ghavami, Erfan Sadeghi, Zahra Safari, Gholamreza AskariEfficacy of resveratrol supplementation in patients with nonalcoholic fatty liver disease: A systematic review and meta-analysis of clinical trialsComplement Ther Clin Pract.(2020 Dec 4)
    193. Resveratrol - Shumin Wei, Xiaoying YuEfficacy of resveratrol supplementation on liver enzymes in patients with non-alcoholic fatty liver disease: A systematic review and meta-analysisComplement Ther Med.(2020 Nov 30)
    194. Resveratrol - Sheida Zeraattalab-Motlagh, Ahmad Jayedi, Sakineh Shab-BidarThe effects of resveratrol supplementation in patients with type 2 diabetes, metabolic syndrome, and nonalcoholic fatty liver disease: an umbrella review of meta-analyses of randomized controlled trialsAm J Clin Nutr.(2021 Nov 8)
    195. Resveratrol - He X, Li Y, Deng X, Xiao X, Zeng JIntegrative evidence construction for resveratrol treatment of nonalcoholic fatty liver disease: preclinical and clinical meta-analyses.Front Pharmacol.(2023)
    196. Pycnogenol - Malekahmadi M, Moradi Moghaddam O, Firouzi S, Daryabeygi-Khotbehsara R, Shariful Islam SM, Norouzy A, Soltani SEffects of pycnogenol on cardiometabolic health: A systematic review and meta-analysis of randomized controlled trials.Pharmacol Res.(2019-Dec)
    197. Saffron - Seyed Mohammad Mousavi, Pari Mokhtari, Omid Asbaghi, Somaye Rigi, Emma Persad, Ahmad Jayedi, Hamid Rezvani, Yahya Mahamat-Saleh, Omid SadeghiDoes saffron supplementation have favorable effects on liver function indicators? A systematic review and meta-analysis of randomized controlled trialsCrit Rev Food Sci Nutr.(2021 Mar 16)
    198. Chlorella - Samira Yarmohammadi, Reza Hosseini-Ghatar, Sahar Foshati, Mojgan Moradi, Niloofar Hemati, Sajjad Moradi, Mohammad Ali Hojjati Kermani, Mohammad Hosein Farzaei, Haroon KhanEffect of Chlorella vulgaris on Liver Function Biomarkers: a Systematic Review and Meta-AnalysisClin Nutr Res.(2021 Jan 29)
    199. Black seed - Gang Tang, Linyu Zhang, Jie Tao, Zhengqiang WeiEffect of Nigella sativa in the treatment of nonalcoholic fatty liver disease: A systematic review and meta-analysis of randomized controlled trialsPhytother Res.(2021 Mar 16)
    200. Black seed - Neda Azizi, Mohammad Reza Amini, Kurosh Djafarian, Sakineh Shab-BidarThe Effects of Nigella sativa Supplementation on Liver Enzymes Levels: a Systematic Review and Meta-analysis of Randomized Controlled TrialsClin Nutr Res.(2021 Jan 29)
    201. Saffron - Amatto PPG, Chaves L, Braga GG, Carmona F, Pereira AMSEffect of Crocus sativus L. (saffron) and crocin in the treatment of patients with type-2 diabetes mellitus: A systematic review and meta-analysis.J Ethnopharmacol.(2023-Sep-29)
    202. S-adenosylmethionine - Tao Guo, Lei Chang, Yusha Xiao, Quanyan LiuS-adenosyl-L-methionine for the treatment of chronic liver disease: a systematic review and meta-analysisPLoS One.(2015 Mar 16)
    203. Cinnamon - de Moura SL, Gomes BGR, Guilarducci MJ, Coelho OGL, Guimarães NS, Gomes JMGEffects of cinnamon supplementation on metabolic biomarkers in individuals with type 2 diabetes: a systematic review and meta-analysis.Nutr Rev.(2024 Jun 25)
    204. Intermittent fasting (IF) - Ranjbar M, Shab-Bidar S, Mohammadi H, Djafarian KEffect of Intermittent Fasting on Liver Function Tests: A Systematic Review and Meta-Analysis of Randomized Clinical Trials.Nutr Rev.(2024 Jun 25)
    205. Propolis - Adeli S, Maroofi M, Pourteymour Fard Tabrizi F, Alipour B, Heidari M, Vajdi M, Abbasalizad-Farhangi MEffects of Propolis Consumption on Glycemic Indices and Liver Enzymes in Adults: A Grading of Recommendations Assessment, Development, and valuation-assessed Systematic Review and Dose-Response Meta-analysis.Clin Ther.(2024 Aug 2)
    206. Probiotics - Mozaffari S, Aliari M, Emamgholipour S, Hosseini H, Amirkiasar PR, Zare M, Katsiki N, Panahi G, Sahebkar AThe effect of probiotic consumption on lipid profile, glycemic index, inflammatory markers, and liver function in NAFLD patients: A systematic review and meta-analysis of randomized controlled trials.J Diabetes Complications.(2024 Jun 6)
    207. Vitamin E - Chee NM, Sinnanaidu RP, Chan WKVitamin E improves serum markers and histology in adults with metabolic dysfunction-associated steatotic liver disease: Systematic review and meta-analysis.J Gastroenterol Hepatol.(2024 Aug 16)
    208. Sumac - Mohit M, Nejati M, Hejazi N, Modaresi SThe efficacy of sumac (Rhus coriaria L.) powder supplementation in biochemical and anthropometric measurements in overweight or obese patients with non-alcoholic fatty liver disease: A double-blind randomized controlled trial.Avicenna J Phytomed.(2024 May-Jun)
    209. Synbiotics - Musazadeh V, Assadian K, Rajabi F, Faghfouri AH, Soleymani Y, Kavyani Z, Najafiyan BThe effect of synbiotics on liver enzymes, obesity indices, blood pressure, lipid profile, and inflammation in patients with non-alcoholic fatty liver: A systematic review and meta-analysis of randomized controlled trials.Pharmacol Res.(2024 Sep 4)
    210. Honey - Lee D, Chiavaroli L, Ayoub-Charette S, Khan TA, Zurbau A, Au-Yeung F, Cheung A, Liu Q, Qi X, Ahmed A, Choo VL, Blanco Mejia S, Malik VS, El-Sohemy A, de Souza RJ, Wolever TMS, Leiter LA, Kendall CWC, Jenkins DJA, Sievenpiper JLImportant Food Sources of Fructose-Containing Sugars and Non-Alcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis of Controlled Trials.Nutrients.(2022-Jul-12)
    211. Mediterranean Diet - Jamil A, Chivese T, Elshaikh U, Sendall MEfficacy of the Mediterranean diet in treating metabolic dysfunction-associated steatotic liver disease (MASLD) in children and adolescents: a systematic review and meta-analysis.BMC Public Health.(2024 Oct 3)
    212. Nicotinamide Mononucleotide - Wang JP, Wang L, Wang T, Zhang YD, Zhou AJ, Wang ZP, Xiong ZEEffects of Nicotinamide Mononucleotide Supplementation on Muscle and Liver Functions Among the Middle-Aged and Elderly: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.Curr Pharm Biotechnol.(2024 Aug 23)
    213. TUDCA - Crosignani A, Battezzati PM, Setchell KD, Invernizzi P, Covini G, Zuin M, Podda MTauroursodeoxycholic acid for treatment of primary biliary cirrhosis. A dose-response study.Dig Dis Sci.(1996 Apr)
    214. TUDCA - Larghi A, Crosignani A, Battezzati PM, De Valle G, Allocca M, Invernizzi P, Zuin M, Podda MUrsodeoxycholic and tauro-ursodeoxycholic acids for the treatment of primary biliary cirrhosis: a pilot crossover study.Aliment Pharmacol Ther.(1997 Apr)
    215. TUDCA - Ma H, Zeng M, Han Y, Yan H, Tang H, Sheng J, Hu H, Cheng L, Xie Q, Zhu Y, Chen G, Gao Z, Xie W, Wang J, Wu S, Wang G, Miao X, Fu X, Duan L, Xu J, Wei L, Shi G, Chen C, Chen M, Ning Q, Yao C, Jia JA multicenter, randomized, double-blind trial comparing the efficacy and safety of TUDCA and UDCA in Chinese patients with primary biliary cholangitis.Medicine (Baltimore).(2016 Nov)
    216. Artichoke Extract - Liu H, Li Y, Jin Y, Li X, Wang D, Yu X, Jiang Z, Yin G, Chen S, Zhang X, Meng D, Yu W, Jiang W, Zhang FEffects of different natural products in patients with non-alcoholic fatty liver disease-A network meta-analysis of randomized controlled trials.Phytother Res.(2024 Jul)
    217. Saffron - Zhang JW, Zhao Q, Li Z, Liu Q, Zang SS, Liu SThe effect of saffron supplementation on liver and kidney function, blood glucose and pressure in patients with diabetes and prediabetes: A grade assessed systematic review and meta-analysis of randomized controlled trials.Prostaglandins Other Lipid Mediat.(2025 Jan 14)
    218. Vitamin D - Li D, Fu N, Wu HEffect of vitamin D supplementation on various parameters in patients with non-alcoholic fatty liver disease: An updated meta-analysis.Clin Exp Hepatol.(2023 Dec)
    219. Fish Oil - Zhou L, Sun D, Bai HEfficacy of fish oil supplementation on metabolic dysfunction-associated steatotic liver disease: a meta-analysis.Front Nutr.(2025)
    220. Intermittent fasting (IF) - Tavakoli A, Akhgarjand C, Ansar H, Houjaghani H, Khormani A, Djafarian K, Rostamian A, Ranjbar M, Farsani GMThe effects of intermittent fasting on antioxidant and inflammatory markers and liver enzymes in postmenopausal, overweight and obese women with rheumatoid arthritis: a randomized controlled trial.Sci Rep.(2025 Jan 18)
    221. Probiotics - Song Y, Liu S, Zhang L, Zhao W, Qin Y, Liu MThe effect of gut microbiome-targeted therapies in nonalcoholic fatty liver disease: a systematic review and network meta-analysis.Front Nutr.(2024)