Type-II Collagen

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    Last Updated: March 26, 2025

    Type II collagen (CII) is a protein and component of joint cartilage. Oral ingestion of CII in its undenatured form may reduce autoimmunity to the body's own CII, resulting in less joint inflammation in instances of osteoarthritis and rheumatism.

    Overview

    Dosage information

    The dose of CII taken depends on whether it is denatured (hydrolyzed) or undenatured. For skin and joint health, the daily dose of hydrolyzed collagen is around 10 grams per day. For treatment of osteoarthritis and rheumatoid arthritis, undenatured collagen is taken at a much lower daily dose (often around 40 milligrams), and while it doesn't need to be taken at any particular time of the day, it may be ideal to take it on an empty stomach before breakfast.

    CII should not be taken as a protein supplement because it has a lackluster amino acid profile.

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    Research Breakdown