Have any supplements been studied for acne vulgaris?

Supplementing with certain minerals, vitamins, and other compounds may improve acne. The most well-supported supplements include zinc, vitamin D, vitamin B5, fish oil, green tea extract, and probiotics. However, some supplements were shown to worsen acne symptoms or lead to breakouts, especially when taken at high doses. These include iodine, whey protein, vitamin B6, and vitamin B12.