Have any supplements been studied for atherosclerosis?

Yes, although exactly which supplements qualify depends on whether you count studies involving markers tightly related to atherosclerosis like LDL-C or only count studies that measure atherosclerosis more directly. A lot more studies have looked at biomarkers related to atherosclerosis than direct measurements. However, since a lot of studies have examined biomarkers like LDL-C and blood-pressure that are firmly established to actually cause atherosclerosis, the evidence base isn’t too bad.

A very incomplete list of supplements examined for impact on atherosclerosis or its biomarkers include:^[1]

• Omega-3 and omega-6 polyunsaturated fatty acids
• garlic and allicin (one of garlic’s main bioactives)
• Plant sterols
• Flavanols
• Fiber
• Antioxidant vitamins such as vitamin-c