Fatigue

Written by:

•Last Updated: November 20, 2025

Fatigue refers to a feeling of tiredness that does not improve with sleep or rest. It can be due to intense and/or prolonged physical and mental activity or due to other causes not related to exertion (e.g., anxiety/depression, medications, disease, pregnancy).

Written by:

Last Updated:November 20, 2025

Research Snapshot

6,194 participants in 17 trials and 5 meta-analyses

Examine Evidence Grades

BAttention + 4 more

C22 outcomes

D26 outcomes

Examine Database: Fatigue

Intervention	Health Outcome	Evidence
Rhodiola Rosea	8 outcomes	4 Studies
Iron	3 outcomes	2 Studies
Ornithine	9 outcomes	2 Studies
Panax Ginseng (Korean Ginseng)	1 outcome	2 Studies
Astaxanthin	4 outcomes	1 Study
Beta-Alanine	1 outcome	1 Study
Beta-glucans	3 outcomes	1 Study
Branched-Chain Amino Acids	5 outcomes	1 Study
Caffeine	1 outcome	1 Study
Coenzyme Q10	1 outcome	1 Study
Guarana	1 outcome	1 Study
L-Carnitine	3 outcomes	1 Study
L-Tyrosine	3 outcomes	1 Study
Meditation	2 outcomes	1 Study
PQQ	4 outcomes	1 Study
Spirulina	3 outcomes	1 Study
Vitamin C	1 outcome	1 Study