Last Updated: October 3 2022

Iron is an essential mineral best known for allowing blood to carry oxygen between tissues. Except in case of deficiency, iron supplementation has no proven benefit; on the contrary, it can lead to iron poisoning.

Iron is most often used for


What is iron?

Iron is an essential dietary mineral present in a wide variety of foods. In its main role in the body, iron is a critical component of hemoglobin — the oxygen carrier of red blood cells — and a deficiency in iron leads to poor oxygen transport (anemia). In addition, iron acts as a cofactor for many enzymes. The iron found in plants (notably grains and legumes) is less bioavailable than the iron found in meat (in the form of heme). Iron is the double-edged sword of the nutrient world. On the one hand, many people have insufficient levels, but on the other hand, iron overload can be toxic to a wide variety of cells. Iron deficiency is the only reason to consider iron supplementation, though getting more iron through foods is preferable when possible. For people who already have enough iron, taking an iron supplement has no proven benefit, and on the contrary, it can lead to iron overdose.

What are the benefits of iron?

A lack of iron tends to produce fatigue, depression, impaired cognitive function, restless leg syndrome, and other adverse effects. Correction of an iron deficiency tends to improve symptoms, and even among people who aren't anemic, more than the bare minimum amount of iron may be needed to produce the optimal amounts of hemoglobin and reap the benefits of greater oxygen delivery; however, the beneficial effect is probably limited to people whose iron levels are low according to conventional standards, though more research is needed. Iron supplements are also often used by athletes in an attempt to improve physical performance, however once again there does not appear to be any benefit when iron levels are not low. Iron deficiency is fairly common, and a great number of factors negatively affect iron status, so iron supplementation and iron-rich diets can be expected to benefit many people.

What are the downsides of iron?

Supplementation can produce nausea, headaches, and other symptoms. As previously mentioned, iron overload is a serious health risk.

Dosage information

Make sure that you get the recommended daily allowance (RDA) for your gender, age, and situation:

  • 8 mg for men and nonmenstruating women
  • 15 mg for menstruating women 14–18 years old
  • 18 mg for menstruating women 19–50 years old
  • 27 mg for pregnant women
  • 10 mg for lactating women less than 18 years old
  • 9 mg for lactating women, 19–50 years old

Those numbers include the iron in your diet. Getting enough iron from foods makes supplementation unnecessary. Be careful not to ingest more iron than the daily tolerable upper intake level (UL) for your age, e.g., 45 mg for people older than 13.

For more details, see the Recommended Intake section below.

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1.^Beard JL, Dawson H, Piñero DJIron metabolism: a comprehensive reviewNutr Rev.(1996)
2.^Sánchez M et al.Iron chemistry at the service of lifeIUBMB Life.(2017)
3.^Gozzelino R, Arosio PIron Homeostasis in Health and DiseaseInt J Mol Sci.(2016)
4.^Bandyopadhyay S, Chandramouli K, Johnson MKIron-sulfur cluster biosynthesisBiochem Soc Trans.(2008)
5.^Lill R, Mühlenhoff UIron-sulfur protein biogenesis in eukaryotes: components and mechanismsAnnu Rev Cell Dev Biol.(2006)
6.^Ayala-Castro C, Saini A, Outten FWFe-S cluster assembly pathways in bacteriaMicrobiol Mol Biol Rev.(2008)
7.^Balk J, Lobréaux SBiogenesis of iron-sulfur proteins in plantsTrends Plant Sci.(2005)
8.^Muthuswamy S, Agarwal SFriedreich Ataxia: From the Eye of a Molecular BiologistNeurologist.(2005)
9.^Bruni F, Lightowlers RN, Chrzanowska-Lightowlers ZMHuman mitochondrial nucleasesFEBS J.(2016)
14.^The American Academy of PediatricsIron Fortification of Infant Formulas.(1999)
18.^ Camaschella, CIron-Deficiency AnemiaN Engl J Med.(2015 May)
21.^Kurtoglu E, Ugur A, Baltaci AK, Undar LEffect of iron supplementation on oxidative stress and antioxidant status in iron-deficiency anemiaBiol Trace Elem Res.(2003 Winter)
22.^Garry PJ, VanderJagt DJ, Wayne SJ, Koehler KH, Rhyne RL, Simon TLA prospective study of blood donations in healthy elderly personsTransfusion.(1991 Oct)
23.^Garry PJ, Koehler KM, Simon TLIron stores and iron absorption: effects of repeated blood donationsAm J Clin Nutr.(1995 Sep)
24.^Baart AM, van Noord PA, Vergouwe Y, Moons KG, Swinkels DW, Wiegerinck ET, de Kort WL, Atsma FHigh prevalence of subclinical iron deficiency in whole blood donors not deferred for low hemoglobinTransfusion.(2013 Aug)
25.^Cable RG, Glynn SA, Kiss JE, Mast AE, Steele WR, Murphy EL, Wright DJ, Sacher RA, Gottschall JL, Tobler LH, Simon TL, NHLBI Retrovirus Epidemiology Donor Study-II (REDS-II)Iron deficiency in blood donors: the REDS-II Donor Iron Status Evaluation (RISE) studyTransfusion.(2012 Apr)
26.^Cable RG, Glynn SA, Kiss JE, Mast AE, Steele WR, Murphy EL, Wright DJ, Sacher RA, Gottschall JL, Vij V, Simon TL, NHLBI Retrovirus Epidemiology Donor Study-IIIron deficiency in blood donors: analysis of enrollment data from the REDS-II Donor Iron Status Evaluation (RISE) studyTransfusion.(2011 Mar)
27.^Shander A, Knight K, Thurer R, Adamson J, Spence RPrevalence and outcomes of anemia in surgery: a systematic review of the literatureAm J Med.(2004 Apr 5)
28.^Kochhar R, Jain K, Thapa BR, Rawal P, Khaliq A, Kochhar R, Bhadada S, Vaiphei K, Varma S, Dutta U, Nain CK, Prasad KK, Singh KClinical presentation of celiac disease among pediatric compared to adolescent and adult patientsIndian J Gastroenterol.(2012 Jun)
29.^Berry N, Basha J, Varma N, Varma S, Prasad KK, Vaiphei K, Dhaka N, Sinha SK, Kochhar RAnemia in celiac disease is multifactorial in etiology: A prospective study from IndiaJGH Open.(2018 Aug 2)
30.^Bottaro G, Cataldo F, Rotolo N, Spina M, Corazza GRThe clinical pattern of subclinical/silent celiac disease: an analysis on 1026 consecutive casesAm J Gastroenterol.(1999 Mar)
31.^Murray JA, Van Dyke C, Plevak MF, Dierkhising RA, Zinsmeister AR, Melton LJ 3rdTrends in the identification and clinical features of celiac disease in a North American community, 1950-2001Clin Gastroenterol Hepatol.(2003 Jan)
33.^Harper JW, Holleran SF, Ramakrishnan R, Bhagat G, Green PHAnemia in celiac disease is multifactorial in etiologyAm J Hematol.(2007 Nov)
34.^Vici G, Belli L, Biondi M, Polzonetti VGluten free diet and nutrient deficiencies: A reviewClin Nutr.(2016 Dec)
35.^Enani G, Bilgic E, Lebedeva E, Delisle M, Vergis A, Hardy KThe incidence of iron deficiency anemia post-Roux-en-Y gastric bypass and sleeve gastrectomy: a systematic reviewSurg Endosc.(2019 Sep 4)
36.^Ganz TMolecular pathogenesis of anemia of chronic diseasePediatr Blood Cancer.(2006 May 1)
38.^Filmann N, Rey J, Schneeweiss S, Ardizzone S, Bager P, Bergamaschi G, Koutroubakis I, Lindgren S, Morena Fde L, Moum B, Vavricka SR, Schröder O, Herrmann E, Blumenstein IPrevalence of anemia in inflammatory bowel diseases in european countries: a systematic review and individual patient data meta-analysisInflamm Bowel Dis.(2014 May)
39.^Cooke AG, McCavit TL, Buchanan GR, Powers JMIron Deficiency Anemia in Adolescents Who Present with Heavy Menstrual BleedingJ Pediatr Adolesc Gynecol.(2017 Apr)
40.^Barr F, Brabin L, Agbaje S, Buseri F, Ikimalo J, Briggs NReducing iron deficiency anaemia due to heavy menstrual blood loss in Nigerian rural adolescentsPublic Health Nutr.(1998 Dec)
42.^Hou B, Zhang M, Liu M, Dai W, Lin Y, Li Y, Gong M, Wang GAssociation of active Helicobacter pylori infection and anemia in elderly malesBMC Infect Dis.(2019 Mar 5)
43.^Zhang ZW, Patchett SE, Perrett D, Katelaris PH, Domizio P, Farthing MJThe relation between gastric vitamin C concentrations, mucosal histology, and CagA seropositivity in the human stomachGut.(1998 Sep)
44.^Calam JHelicobacter pylori modulation of gastric acidYale J Biol Med.(1999 Mar-Jun)
46.^Rood JC, Ruiz B, Fontham ET, Malcom GT, Hunter FM, Sobhan M, Johnson WD, Correa PHelicobacter pylori-associated gastritis and the ascorbic acid concentration in gastric juiceNutr Cancer.(1994)
47.^Sobala GM, Schorah CJ, Shires S, Lynch DA, Gallacher B, Dixon MF, Axon ATEffect of eradication of Helicobacter pylori on gastric juice ascorbic acid concentrationsGut.(1993 Aug)
48.^McMahon LPIron deficiency in pregnancyObstet Med.(2010 Mar)
50.^Pietrangelo AMechanisms of iron hepatotoxicityJ Hepatol.(2016 Jul)
51.^Day SM, Duquaine D, Mundada LV, Menon RG, Khan BV, Rajagopalan S, Fay WPChronic iron administration increases vascular oxidative stress and accelerates arterial thrombosisCirculation.(2003 May 27)
52.^Horwitz LD, Rosenthal EAIron-mediated cardiovascular injuryVasc Med.(1999)
53.^Glei M, Latunde-Dada GO, Klinder A, Becker TW, Hermann U, Voigt K, Pool-Zobel BLIron-overload induces oxidative DNA damage in the human colon carcinoma cell line HT29 clone 19AMutat Res.(2002 Aug 26)
54.^Winterbourn CCToxicity of iron and hydrogen peroxide: the Fenton reactionToxicol Lett.(1995 Dec)
55.^Kehrer JPThe Haber-Weiss reaction and mechanisms of toxicityToxicology.(2000 Aug 14)
56.^Crichton RR, Wilmet S, Legssyer R, Ward RJMolecular and cellular mechanisms of iron homeostasis and toxicity in mammalian cellsJ Inorg Biochem.(2002 Jul 25)
57.^Brissot P, Ropert M, Le Lan C, Loréal ONon-transferrin bound iron: a key role in iron overload and iron toxicityBiochim Biophys Acta.(2012 Mar)
58.^Aljwaid H, White DL, Collard KJ, Moody AJ, Pinkney JHNon-transferrin-bound iron is associated with biomarkers of oxidative stress, inflammation and endothelial dysfunction in type 2 diabetesJ Diabetes Complications.(2015 Sep-Oct)
59.^Lee DH, Liu DY, Jacobs DR Jr, Shin HR, Song K, Lee IK, Kim B, Hider RCCommon presence of non-transferrin-bound iron among patients with type 2 diabetesDiabetes Care.(2006 May)
60.^Imam MU, Zhang S, Ma J, Wang H, Wang FAntioxidants Mediate Both Iron Homeostasis and Oxidative StressNutrients.(2017 Jun 28)
63.^Jiao Y, Wilkinson J 4th, Di X, Wang W, Hatcher H, Kock ND, D'Agostino R Jr, Knovich MA, Torti FM, Torti SVCurcumin, a cancer chemopreventive and chemotherapeutic agent, is a biologically active iron chelatorBlood.(2009 Jan 8)
65.^Tang Y, Li Y, Yu H, Gao C, Liu L, Chen S, Xing M, Liu L, Yao PQuercetin prevents ethanol-induced iron overload by regulating hepcidin through the BMP6/SMAD4 signaling pathwayJ Nutr Biochem.(2014 Jun)
66.^Moayedi Esfahani BA, Reisi N, Mirmoghtadaei MEvaluating the safety and efficacy of silymarin in β-thalassemia patients: a reviewHemoglobin.(2015)
67.^Morgan EH, Oates PSMechanisms and regulation of intestinal iron absorptionBlood Cells Mol Dis.(2002 Nov-Dec)
68.^Sharp P, Srai SKMolecular mechanisms involved in intestinal iron absorptionWorld J Gastroenterol.(2007 Sep 21)
69.^Le Blanc S, Garrick MD, Arredondo MHeme carrier protein 1 transports heme and is involved in heme-Fe metabolismAm J Physiol Cell Physiol.(2012 Jun 15)
70.^Cabantchik ZI, Kakhlon O, Epsztejn S, Zanninelli G, Breuer WIntracellular and extracellular labile iron poolsAdv Exp Med Biol.(2002)
71.^Carpenter CE, Mahoney AWContributions of heme and nonheme iron to human nutritionCrit Rev Food Sci Nutr.(1992)
72.^Ganz T, Nemeth EHepcidin and iron homeostasisBiochim Biophys Acta.(2012 Sep)
74.^Stoffel NU, Zeder C, Brittenham GM, Moretti D, Zimmermann MBIron absorption from supplements is greater with alternate day than with consecutive day dosing in iron-deficient anemic womenHaematologica.(2019 Aug 14)
75.^Moretti D, Goede JS, Zeder C, Jiskra M, Chatzinakou V, Tjalsma H, Melse-Boonstra A, Brittenham G, Swinkels DW, Zimmermann MBOral iron supplements increase hepcidin and decrease iron absorption from daily or twice-daily doses in iron-depleted young womenBlood.(2015 Oct 22)
76.^Adaji JA, Isah AY, Agida ET, Otu T, Abdullahi HIDaily versus twice daily dose of ferrous sulphate supplementation in pregnant women: A randomized clinical trialNiger J Clin Pract.(2019 Aug)
79.^Lynch SR, Hurrell RF, Dassenko SA, Cook JDThe effect of dietary proteins on iron bioavailability in manAdv Exp Med Biol.(1989)
81.^Baech SB, Hansen M, Bukhave K, Jensen M, Sørensen SS, Kristensen L, Purslow PP, Skibsted LH, Sandström BNonheme-iron absorption from a phytate-rich meal is increased by the addition of small amounts of pork meatAm J Clin Nutr.(2003 Jan)
83.^Santiago Navas-Carretero, Ana M Pérez-Granados, Beatriz Sarriá, Angeles Carbajal, Mercedes M Pedrosa, Mark A Roe, Susan J Fairweather-Tait, M Pilar VaqueroOily fish increases iron bioavailability of a phytate rich meal in young iron deficient womenJ Am Coll Nutr.(2008 Feb)
87.^Rosen GM, Morrissette S, Larson A, Stading P, Griffin KH, Barnes TLUse of a Probiotic to Enhance Iron Absorption in a Randomized Trial of Pediatric Patients Presenting with Iron DeficiencyJ Pediatr.(2019 Apr)
88.^Simeoni M, Citraro ML, Cerantonio A, Deodato F, Provenzano M, Cianfrone P, Capria M, Corrado S, Libri E, Comi A, Pujia A, Abenavoli L, Andreucci M, Cocchi M, Montalcini T, Fuiano GAn open-label, randomized, placebo-controlled study on the effectiveness of a novel probiotics administration protocol (ProbiotiCKD) in patients with mild renal insufficiency (stage 3a of CKD)Eur J Nutr.(2019 Aug)
89.^Sazawal S, Dhingra U, Hiremath G, Sarkar A, Dhingra P, Dutta A, Menon VP, Black REEffects of Bifidobacterium lactis HN019 and prebiotic oligosaccharide added to milk on iron status, anemia, and growth among children 1 to 4 years oldJ Pediatr Gastroenterol Nutr.(2010 Sep)
91.^Atanassova BD, Tzatchev KNAscorbic acid--important for iron metabolismFolia Med (Plovdiv).(2008)
97.^Cox EVThe anemia of scurvyVitam Horm.(1968)
98.^da Cunha MSB, Campos Hankins NA, Arruda SFEffect of vitamin A supplementation on iron status in humans: A systematic review and meta-analysisCrit Rev Food Sci Nutr.(2019)
99.^Cañete A, Cano E, Muñoz-Chápuli R, Carmona RRole of Vitamin A/Retinoic Acid in Regulation of Embryonic and Adult HematopoiesisNutrients.(2017 Feb 20)
100.^García-Casal MN, Layrisse M, Solano L, Barón MA, Arguello F, Llovera D, Ramírez J, Leets I, Tropper EVitamin A and beta-carotene can improve nonheme iron absorption from rice, wheat and corn by humansJ Nutr.(1998 Mar)
101.^Masoud MS, Alokail MS, Yakout SM, Khattak MNK, AlRehaili MM, Wani K, Al-Daghri NMVitamin D Supplementation Modestly Reduces Serum Iron Indices of Healthy Arab AdolescentsNutrients.(2018 Dec 2)
102.^Braithwaite VS, Crozier SR, D'Angelo S, Prentice A, Cooper C, Harvey NC, Jones KS, MAVIDOS Trial GroupThe Effect of Vitamin D Supplementation on Hepcidin, Iron Status, and Inflammation in Pregnant Women in the United KingdomNutrients.(2019 Jan 18)
104.^Smith EM, Alvarez JA, Kearns MD, Hao L, Sloan JH, Konrad RJ, Ziegler TR, Zughaier SM, Tangpricha VHigh-dose vitamin D3 reduces circulating hepcidin concentrations: A pilot, randomized, double-blind, placebo-controlled trial in healthy adultsClin Nutr.(2017 Aug)
105.^Cook JD, Dassenko SA, Whittaker PCalcium supplementation: effect on iron absorptionAm J Clin Nutr.(1991 Jan)
106.^Seligman PA, Caskey JH, Frazier JL, Zucker RM, Podell ER, Allen RHMeasurements of iron absorption from prenatal multivitamin--mineral supplementsObstet Gynecol.(1983 Mar)
107.^Dawson-Hughes B, Seligson FH, Hughes VAEffects of calcium carbonate and hydroxyapatite on zinc and iron retention in postmenopausal womenAm J Clin Nutr.(1986 Jul)
108.^Candia V, Ríos-Castillo I, Carrera-Gil F, Vizcarra B, Olivares M, Chaniotakis S, Pizarro FEffect of various calcium salts on non-heme iron bioavailability in fasted women of childbearing ageJ Trace Elem Med Biol.(2018 Sep)
109.^Gaitán D, Flores S, Saavedra P, Miranda C, Olivares M, Arredondo M, López de Romaña D, Lönnerdal B, Pizarro FCalcium does not inhibit the absorption of 5 milligrams of nonheme or heme iron at doses less than 800 milligrams in nonpregnant womenJ Nutr.(2011 Sep)
110.^Hallberg L, Brune M, Erlandsson M, Sandberg AS, Rossander-Hultén LCalcium: effect of different amounts on nonheme- and heme-iron absorption in humansAm J Clin Nutr.(1991 Jan)
112.^Kono Y1, Kashine S, Yoneyama T, Sakamoto Y, Matsui Y, Shibata HIron chelation by chlorogenic acid as a natural antioxidantBiosci Biotechnol Biochem.(1998 Jan)
113.^Samman S1, Sandström B, Toft MB, Bukhave K, Jensen M, Sørensen SS, Hansen MGreen tea or rosemary extract added to foods reduces nonheme-iron absorptionAm J Clin Nutr.(2001 Mar)
114.^O'Coinceanainn M1, Bonnely S, Baderschneider B, Hynes MJReaction of iron(III) with theaflavin: complexation and oxidative productsJ Inorg Biochem.(2004 Apr)
115.^Jiao Y1, Wilkinson J 4th, Di X, Wang W, Hatcher H, Kock ND, D'Agostino R Jr, Knovich MA, Torti FM, Torti SVCurcumin, a cancer chemopreventive and chemotherapeutic agent, is a biologically active iron chelatorBlood.(2009 Jan 8)
116.^Tuntipopipat S1, Judprasong K, Zeder C, Wasantwisut E, Winichagoon P, Charoenkiatkul S, Hurrell R, Walczyk TChili, but not turmeric, inhibits iron absorption in young women from an iron-fortified composite mealJ Nutr.(2006 Dec)
117.^Fernandez R, Phillips SFComponents of fiber bind iron in vitroAm J Clin Nutr.(1982 Jan)
119.^Rossander LEffect of dietary fiber on iron absorption in manScand J Gastroenterol Suppl.(1987)
122.^Anderson JW1, Zettwoch N, Feldman T, Tietyen-Clark J, Oeltgen P, Bishop CWCholesterol-lowering effects of psyllium hydrophilic mucilloid for hypercholesterolemic menArch Intern Med.(1988 Feb)
123.^Sajadi Hezaveh Z, Azarkeivan A, Janani L, Hosseini S, Shidfar FThe effect of quercetin on iron overload and inflammation in β-thalassemia major patients: A double-blind randomized clinical trialComplement Ther Med.(2019 Oct)
124.^Leopoldini M, Russo N, Chiodo S, Toscano MIron chelation by the powerful antioxidant flavonoid quercetinJ Agric Food Chem.(2006 Aug 23)
125.^Liuzzi JP, Aydemir F, Nam H, Knutson MD, Cousins RJZip14 (Slc39a14) mediates non-transferrin-bound iron uptake into cellsProc Natl Acad Sci U S A.(2006 Sep 12)
126.^Espinoza A, Le Blanc S, Olivares M, Pizarro F, Ruz M, Arredondo MIron, copper, and zinc transport: inhibition of divalent metal transporter 1 (DMT1) and human copper transporter 1 (hCTR1) by shRNABiol Trace Elem Res.(2012 May)
127.^Olivares M, Pizarro F, Ruz M, de Romaña DLAcute inhibition of iron bioavailability by zinc: studies in humansBiometals.(2012 Aug)
129.^Nguyen P, Grajeda R, Melgar P, Marcinkevage J, Flores R, Ramakrishnan U, Martorell REffect of zinc on efficacy of iron supplementation in improving iron and zinc status in womenJ Nutr Metab.(2012)
130.^Donangelo CM, Woodhouse LR, King SM, Viteri FE, King JCSupplemental zinc lowers measures of iron status in young women with low iron reservesJ Nutr.(2002 Jul)
131.^de Brito NJ, Rocha ÉD, de Araújo Silva A, Costa JB, França MC, das Graças Almeida M, Brandão-Neto JOral zinc supplementation decreases the serum iron concentration in healthy schoolchildren: a pilot studyNutrients.(2014 Sep 4)
132.^Lopez de Romaña D, Ruz M, Pizarro F, Landeta L, Olivares MASupplementation with zinc between meals has no effect on subsequent iron absorption or on iron status of Chilean womenNutrition.(2008 Oct)
136.^Naslı-Esfahani E, Larijani B, Amini P, Ghodssi-Ghassemabadi R, Razmandeh REffect of treatment of iron deficiency anemia onhemoglobin A1c in type 2 diabetic patientsTurk J Med Sci.(2017 Nov 13)
137.^Renz PB, Hernandez MK, Camargo JLEffect of iron supplementation on HbA1c levels in pregnant women with and without anaemiaClin Chim Acta.(2018 Mar)
138.^Gram-Hansen P, Eriksen J, Mourits-Andersen T, Olesen LGlycosylated haemoglobin (HbA1c) in iron- and vitamin B12 deficiencyJ Intern Med.(1990 Feb)
142.^Vafa M, Azizi-Soleiman F, Kazemi SM, Salehi M, Zaeri F, Abiri B, Sadeghi H, Safavi MComparing the effectiveness of vitamin D plus iron vs vitamin D on depression scores in anemic females: Randomized triple-masked trialMed J Islam Repub Iran.(2019 Jul 3)
143.^Wassef A, Nguyen QD, St-André MAnaemia and depletion of iron stores as risk factors for postpartum depression: a literature reviewJ Psychosom Obstet Gynaecol.(2019 Mar)
144.^Beard JL, Hendricks MK, Perez EM, Murray-Kolb LE, Berg A, Vernon-Feagans L, Irlam J, Isaacs W, Sive A, Tomlinson MMaternal iron deficiency anemia affects postpartum emotions and cognitionJ Nutr.(2005 Feb)
145.^Sheikh M, Hantoushzadeh S, Shariat M, Farahani Z, Ebrahiminasab OThe efficacy of early iron supplementation on postpartum depression, a randomized double-blind placebo-controlled trialEur J Nutr.(2017 Mar)
148.^Tomer Avni, Shelley Reich, Nirit Lev, Anat Gafter-GviliIron supplementation for restless legs syndrome - A systematic review and meta-analysisEur J Intern Med.(2019 May)
149.^Chung J, Chen C, Paw BHHeme metabolism and erythropoiesisCurr Opin Hematol.(2012)
150.^Bonaventura C et al.Molecular controls of the oxygenation and redox reactions of hemoglobinAntioxid Redox Signal.(2013)
152.^Bender MA, Douthitt Seibel GSickle Cell DiseaseGene Reviews.(2003)
153.^Chan CQ, Low LL, Lee KHOral Vitamin B12 Replacement for the Treatment of Pernicious AnemiaFront Med (Lausanne).(2016)
155.^Johnson-Wimbley TD, Graham DYDiagnosis and management of iron deficiency anemia in the 21st centuryTherap Adv Gastroenterol.(2011)
156.^Clark SFIron deficiency anemia: diagnosis and managementCurr Opin Gastroenterol.(2009)
159.^Wynn TA, Chawla A, Pollard JWMacrophage biology in development, homeostasis and diseaseNature.(2013)
160.^Alam MZ, Devalaraja S, Haldar MThe Heme Connection: Linking Erythrocytes and Macrophage BiologyFront Immunol.(2017)
161.^Kumar S, Bandyopadhyay UFree heme toxicity and its detoxification systems in humanToxicol Lett.(2005)
164.^Houston BL, Hurrie D, Graham J, Perija B, Rimmer E, Rabbani R, Bernstein CN, Turgeon AF, Fergusson DA, Houston DS, Abou-Setta AM, Zarychanski REfficacy of iron supplementation on fatigue and physical capacity in non-anaemic iron-deficient adults: a systematic review of randomised controlled trialsBMJ Open.(2018 Apr 5)