Hair loss can affect the scalp or other areas of the body where hair grows and may occur gradually or suddenly and dramatically. It may result from aging, genetics, hormonal changes, or medical conditions.
Hair Loss falls under theSkin, Hair, & Nailscategory.
Hair loss, also known as alopecia, refers to the loss of hair on the body. There are various types of hair loss, all of which tend to differ in their underlying causes, prevalence, and the pattern in which hair is lost. Common types of hair loss include male- and female-pattern hair loss (collectively referred to as androgenic alopecia; AGA), alopecia areata, telogen effluvium, and anagen effluvium.
Male-pattern hair loss typically begins with hair loss at the front of the hairline and/or on the crown of the head, with hair loss progression over time. Female-pattern hair loss tends to feature diffuse hair thinning and hair loss across the top of the head, especially near the center of the scalp. Alopecia areata involves hair loss in patches, which can regrow or precede complete loss of hair. Telogen effluvium and anagen effluvium both involve hair thinning and hair loss across the scalp.
A medical professional may use various methodologies to diagnose hair loss, including visual examination, medical history, biopsy, and laboratory testing.
One procedure often employed is a hair pull test. In this test, a small section of hair is grasped and gently pulled on, with the process repeated at various areas of the scalp. The number of hairs that come out upon pulling can indicate if hair loss is occurring and its severity.
The only two drugs currently approved by the FDA for the treatment of androgenic alopecia are minoxidil (used topically) and finasteride (taken orally). Of these, minoxidil is approved for the treatment of both male- and female-pattern hair loss, while finasteride is only approved for men with male-pattern hair loss. Other treatments used for androgenic alopecia include dutasteride, prostaglandin analogs (e.g., latanoprost), injection with platelet-rich plasma, and anti-androgens (for women with hair loss due to high androgen levels).
The first-line treatment for alopecia areata is the injection of corticosteroids into sites of hair loss.
Several RCTs have tested the effect of individual supplements on hair loss, given either orally (including vitamin E and saw palmetto) or applied topically to the scalp (including pumpkin seed oil, melatonin, and procyanidin from apples). A number of studies have also examined the effect of oral supplements containing a mixture of compounds, typically a combination of nutrients (e.g., amino acids and vitamins).
Research on the effect of diet on hair loss is very limited. One small case-control study found that men with high intakes of either raw vegetables or fresh herbs were less likely to have AGA. In rare cases, certain nutrient deficiencies may lead to hair loss (especially in susceptible individuals), with one example being iron deficiency anemia.
Low-level laser therapy (LLLT) involves the application of red and infrared light onto areas of the scalp, and available evidence indicates LLLT can prevent hair loss and potentially support hair regrowth in AGA.
Microneedling (a procedure in which the skin is repeatedly punctured by a large number of very small needles) may be able to enhance the effects of minoxidil in preventing hair loss and producing hair regrowth in AGA.
Ketoconazole is an antifungal medication that may reduce hair loss and potentially promote hair regrowth in AGA when applied to the scalp via medicated shampoo.
Male-pattern baldness is due in large part to an androgen (a so-called “male hormone") called dihydrotestosterone (DHT), which can sometimes contribute to female-pattern baldness as well. Other factors – like aging and genetics – can also increase the risk of male- and female-pattern baldness.
Alopecia areata is the result of the body's immune cells attacking hair follicles, resulting in inflammation and eventual hair loss.
Hair loss can also be the result of medical conditions, medications, and infection.
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- ^Ji Qi, Luis A GarzaAn overview of alopeciasCold Spring Harb Perspect Med.(2014 Mar 1)
- ^Ho CH, Sood T, Zito PMAndrogenetic AlopeciaStatPearls.(2021-11)
- ^T Grant Phillips, W Paul Slomiany, Robert AllisonHair Loss: Common Causes and TreatmentAm Fam Physician.(2017 Sep 15)
- ^Katherine A McDonald, Amanda J Shelley, Sophia Colantonio, Jennifer BeeckerHair pull test: Evidence-based update and revision of guidelinesJ Am Acad Dermatol.(2017 Mar)
- ^Kenia Lepe, Patrick M. ZitoAlopecia Areata
- ^Anna-Marie Hosking, Margit Juhasz, Natasha Atanaskova MesinkovskaComplementary and Alternative Treatments for Alopecia: A Comprehensive ReviewSkin Appendage Disord.(2019 Feb)
- ^Cristina Fortes, S Mastroeni, T Mannooranparampil, D Abeni, A PanebiancoMediterranean diet: fresh herbs and fresh vegetables decrease the risk of Androgenetic Alopecia in malesArch Dermatol Res.(2018 Jan)
- ^Leonid Benjamin Trost, Wilma Fowler Bergfeld, Ellen CalogerasThe diagnosis and treatment of iron deficiency and its potential relationship to hair lossJ Am Acad Dermatol.(2006 May)
- ^Andjela Egger, Sydney R Resnik, Divya Aickara, Eric Maranda, Michael Kaiser, Tongyu C Wikramanayake, Joaquin J JimenezExamining the Safety and Efficacy of Low-Level Laser Therapy for Male and Female Pattern Hair Loss: A Review of the LiteratureSkin Appendage Disord.(2020 Sep)
- ^Robert S English Jr, Sophia Ruiz, Pedro DoAmaralMicroneedling and Its Use in Hair Loss Disorders: A Systematic ReviewDermatol Ther (Heidelb).(2022 Jan)
- ^Jaime R Fields, Peter M Vonu, Reesa L Monir, Jennifer J SchochTopical ketoconazole for the treatment of androgenetic alopecia: A systematic reviewDermatol Ther.(2020 Jan)
- ^Liu F, Hamer MA, Heilmann S, Herold C, Moebus S, Hofman A, Uitterlinden AG, Nöthen MM, van Duijn CM, Nijsten TE, Kayser MPrediction of male-pattern baldness from genotypes.Eur J Hum Genet.(2016-06)
- ^Hagenaars SP, Hill WD, Harris SE, Ritchie SJ, Davies G, Liewald DC, Gale CR, Porteous DJ, Deary IJ, Marioni REGenetic prediction of male pattern baldness.PLoS Genet.(2017-02)
- ^Kaufman KD, Olsen EA, Whiting D, Savin R, DeVillez R, Bergfeld W, Price VH, Van Neste D, Roberts JL, Hordinsky M, Shapiro J, Binkowitz B, Gormley GJFinasteride in the treatment of men with androgenetic alopecia. Finasteride Male Pattern Hair Loss Study Group.J Am Acad Dermatol.(1998-Oct)
- ^Olsen EA, Hordinsky M, Whiting D, Stough D, Hobbs S, Ellis ML, Wilson T, Rittmaster RS,The importance of dual 5alpha-reductase inhibition in the treatment of male pattern hair loss: results of a randomized placebo-controlled study of dutasteride versus finasteride.J Am Acad Dermatol.(2006-Dec)
- ^Uygur MC, Arik AI, Altuğ U, Erol DEffects of the 5 alpha-reductase inhibitor finasteride on serum levels of gonadal, adrenal, and hypophyseal hormones and its clinical significance: a prospective clinical study.Steroids.(1998-Apr)
- ^Glynis AblonA 3-month, randomized, double-blind, placebo-controlled study evaluating the ability of an extra-strength marine protein supplement to promote hair growth and decrease shedding in women with self-perceived thinning hairDermatol Res Pract.(2015)
- ^Trüeb RMSerum Biotin Levels in Women Complaining of Hair LossInt J Trichology.(2016 Apr-Jun)
- ^van der Merwe J, Brooks NE, Myburgh KHThree weeks of creatine monohydrate supplementation affects dihydrotestosterone to testosterone ratio in college-aged rugby playersClin J Sport Med.(2009 Sep)
- ^Hamada K, Randall VAInhibitory autocrine factors produced by the mesenchyme-derived hair follicle dermal papilla may be a key to male pattern baldnessBr J Dermatol.(2006 Apr)
- ^Trüeb RMMolecular mechanisms of androgenetic alopeciaExp Gerontol.(2002 Aug-Sep)
- ^Vatani DS, Faraji J, Soori R, Mogharnasi MThe effects of creatine supplementation on performance and hormonal response in amateur swimmersSCI SPORT.(2011 NOV)
- ^Arazi H, Rahmaninia F, Hosseini K, Asadi AEffects of short term creatine supplementation and resistance exercises on resting hormonal and cardiovascular responsesSCI SPORT.(2015 APR)
- ^Cook CJ, Crewther BT, Kilduff LP, Drawer S, Gaviglio CMSkill execution and sleep deprivation: effects of acute caffeine or creatine supplementation - a randomized placebo-controlled trialJ Int Soc Sports Nutr.(2011 Feb 16)
- ^Cooke MB, Brabham B, Buford TW, Shelmadine BD, McPheeters M, Hudson GM, Stathis C, Greenwood M, Kreider R, Willoughby DSCreatine supplementation post-exercise does not enhance training-induced adaptations in middle to older aged malesEur J Appl Physiol.(2014 Jun)
- ^Crowe MJ, O'Connor DM, Lukins JEThe effects of beta-hydroxy-beta-methylbutyrate (HMB) and HMB/creatine supplementation on indices of health in highly trained athletesInt J Sport Nutr Exerc Metab.(2003 Jun)
- ^Hoffman J, Ratamess N, Kang J, Mangine G, Faigenbaum A, Stout JEffect of creatine and beta-alanine supplementation on performance and endocrine responses in strength/power athletesInt J Sport Nutr Exerc Metab.(2006 Aug)
- ^Eijnde BO, Hespel PShort-term creatine supplementation does not alter the hormonal response to resistance trainingMed Sci Sports Exerc.(2001 Mar)
- ^Volek JS, Ratamess NA, Rubin MR, Gómez AL, French DN, McGuigan MM, Scheett TP, Sharman MJ, Häkkinen K, Kraemer WJThe effects of creatine supplementation on muscular performance and body composition responses to short-term resistance training overreachingEur J Appl Physiol.(2004 May)
- ^Faraji H, Arazi H, Vatani D, Hakimi MThe effects of creatine supplementation on sprint running performance and selected hormonal responsesS AFR J RES SPORT PH.(2010)
- ^Rahimi R, Faraji H, Vatani DS, Qaderi MCreatine supplementation alters the body's hormonal response to exerciseKinesiology.(2010 JAN)
- ^Volek JS, Boetes M, Bush JA, Putukian M, Sebastianelli WJ, Jraemer WJResponse of Testosterone and Cortisol Concentrations to High-Intensity Resistance Exercise Following Creatine SupplementationJ STRENGTH COND RES.(1997)
- Hair Regrowth - Arca E, Açikgöz G, Taştan HB, Köse O, Kurumlu ZAn open, randomized, comparative study of oral finasteride and 5% topical minoxidil in male androgenetic alopeciaDermatology.(2004)
- Hair Regrowth - Berger RS, Fu JL, Smiles KA, Turner CB, Schnell BM, Werchowski KM, Lammers KMThe effects of minoxidil, 1% pyrithione zinc and a combination of both on hair density: a randomized controlled trialBr J Dermatol.(2003 Aug)
- Hair Regrowth - Ulrike Blume-Peytavi, Kathrin Hillmann, Ekkehart Dietz, Douglas Canfield, Natalie Garcia BartelsA randomized, single-blind trial of 5% minoxidil foam once daily versus 2% minoxidil solution twice daily in the treatment of androgenetic alopecia in womenJ Am Acad Dermatol.(2011 Dec)
- Hair Regrowth - Price VH, Menefee E, Strauss PCChanges in hair weight and hair count in men with androgenetic alopecia, after application of 5% and 2% topical minoxidil, placebo, or no treatmentJ Am Acad Dermatol.(1999 Nov)
- Hair Regrowth - Olsen EA, Dunlap FE, Funicella T, Koperski JA, Swinehart JM, Tschen EH, Trancik RJA randomized clinical trial of 5% topical minoxidil versus 2% topical minoxidil and placebo in the treatment of androgenetic alopecia in menJ Am Acad Dermatol.(2002 Sep)
- Hair Regrowth - Olsen EA, Whiting D, Bergfeld W, Miller J, Hordinsky M, Wanser R, Zhang P, Kohut BA multicenter, randomized, placebo-controlled, double-blind clinical trial of a novel formulation of 5% minoxidil topical foam versus placebo in the treatment of androgenetic alopecia in menJ Am Acad Dermatol.(2007 Nov)
- Hair Regrowth - Lucky AW, Piacquadio DJ, Ditre CM, Dunlap F, Kantor I, Pandya AG, Savin RC, Tharp MDA randomized, placebo-controlled trial of 5% and 2% topical minoxidil solutions in the treatment of female pattern hair lossJ Am Acad Dermatol.(2004 Apr)
- Hair Regrowth - Tsuboi R, Arano O, Nishikawa T, Yamada H, Katsuoka KRandomized clinical trial comparing 5% and 1% topical minoxidil for the treatment of androgenetic alopecia in Japanese menJ Dermatol.(2009 Aug)
- Hair Regrowth - Rossi A, Mari E, Scarno M, Garelli V, Maxia C, Scali E, Iorio A, Carlesimo MComparitive effectiveness of finasteride vs Serenoa repens in male androgenetic alopecia: a two-year studyInt J Immunopathol Pharmacol.(2012 Oct-Dec)
- Hair Regrowth - Beoy LA, Woei WJ, Hay YKEffects of tocotrienol supplementation on hair growth in human volunteersTrop Life Sci Res.(2010 Dec)
- Hair Regrowth - Lueangarun S, Visutjindaporn P, Parcharoen Y, Jamparuang P, Tempark TA Systematic Review and Meta-analysis of Randomized Controlled Trials of United States Food and Drug Administration-Approved, Home-use, Low-Level Light/Laser Therapy Devices for Pattern Hair Loss: Device Design and Technology.J Clin Aesthet Dermatol.(2021-Nov)