What are some of the main medical treatments for sarcopenia?

    Researchedby:

    Fact-checked

    by:

    Last Updated: October 25, 2023

    No specific drugs have been approved for the treatment of sarcopenia. Testosterone treatment may increase muscle mass and strength in older men with low serum testosterone levels (<200–300 ng/mL) and muscle weakness.[1] In addition, preliminary evidence suggests that myostatin inhibitors, which block the actions of myostatin — a protein secreted by muscle cells that inhibits protein synthesis and hypertrophy — may increase muscle mass and some measures of physical performance.[2][3] However, the medical use of myostatin inhibitors as a treatment of sarcopenia is currently limited to clinical trials.

    References

    1. ^Anton De Spiegeleer, David Beckwée, Ivan Bautmans, Mirko Petrovic, Sarcopenia Guidelines Development group of the Belgian Society of Gerontology and Geriatrics (BSGG)Pharmacological Interventions to Improve Muscle Mass, Muscle Strength and Physical Performance in Older People: An Umbrella Review of Systematic Reviews and Meta-analysesDrugs Aging.(2018 Aug)
    2. ^Clemens Becker, Stephen R Lord, Stephanie A Studenski, Stuart J Warden, Roger A Fielding, Christopher P Recknor, Marc C Hochberg, Serge L Ferrari, Hubert Blain, Ellen F Binder, Yves Rolland, Serge Poiraudeau, Charles T Benson, Stephen L Myers, Leijun Hu, Qasim I Ahmad, Kelli R Pacuch, Elisa V Gomez, Olivier Benichou, STEADY GroupMyostatin antibody (LY2495655) in older weak fallers: a proof-of-concept, randomised, phase 2 trialLancet Diabetes Endocrinol.(2015 Dec)
    3. ^Daniel Rooks, Jens Praestgaard, Sam Hariry, Didier Laurent, Olivier Petricoul, Robert G Perry, Estelle Lach-Trifilieff, Ronenn RoubenoffTreatment of Sarcopenia with Bimagrumab: Results from a Phase II, Randomized, Controlled, Proof-of-Concept StudyJ Am Geriatr Soc.(2017 Sep)