Upper Respiratory Tract Infection

    Written by:
    Louie Neri
    Last Updated: January 28, 2025

    Upper respiratory tract infection refers to many different infections that can occur in the upper airways, with the common cold being just one type. These infections can cause inflammation and irritation in areas like the larynx, pharynx, nose, sinuses, and nostrils.

    Upper Respiratory Tract Infection falls under the Immunity & Infectious Disease category.

    23,866 participants in 42 trials and 3 meta-analyses

    Examine Database: Upper Respiratory Tract Infection

    Research FeedRead all studies

    Examine Database References

    1. Upper Respiratory Tract Infection Risk - Pitt HA, Costrini AMVitamin C prophylaxis in marine recruitsJAMA.(1979 Mar 2)
    2. Upper Respiratory Tract Infection Risk - Constantini NW, Dubnov-Raz G, Eyal BB, Berry EM, Cohen AH, Hemilä HThe effect of vitamin C on upper respiratory infections in adolescent swimmers: a randomized trialEur J Pediatr.(2011 Jan)
    3. Upper Respiratory Tract Infection Risk - Anderson TW, Beaton GH, Corey P, Spero LWinter illness and vitamin C: the effect of relatively low dosesCan Med Assoc J.(1975 Apr 5)
    4. Upper Respiratory Tract Infection Risk - Coulehan JL, Eberhard S, Kapner L, Taylor F, Rogers K, Garry PVitamin C and acute illness in Navajo school childrenN Engl J Med.(1976 Oct 28)
    5. Upper Respiratory Tract Infection Risk - Carson M, Cox H, Corbett M, Pollitt NVitamin C and the common coldJ Soc Occup Med.(1975 Jul)
    6. Upper Respiratory Tract Infection Risk - Ludvigsson J, Hansson LO, Tibbling GVitamin C as a preventive medicine against common colds in childrenScand J Infect Dis.(1977)
    7. Upper Respiratory Tract Infection Risk - Hunt C, Chakravorty NK, Annan GThe clinical and biochemical effects of vitamin C supplementation in short-stay hospitalized geriatric patientsInt J Vitam Nutr Res.(1984)
    8. Upper Respiratory Tract Infection Risk - Peters EM, Goetzsche JM, Grobbelaar B, Noakes TDVitamin C supplementation reduces the incidence of postrace symptoms of upper-respiratory-tract infection in ultramarathon runnersAm J Clin Nutr.(1993 Feb)
    9. Upper Respiratory Tract Infection Risk - Gormly PJMegadosage of ascorbic acid in an Antarctic expeditionBr J Nutr.(1977 Mar)
    10. Upper Respiratory Tract Infection Risk - Himmelstein S, Robergs R, Koehler K, Lewis S, Qualls CVitamin C supplementation and upper respiratory tract infections in marathon runnersJ Exerc Physiol Online.()
    11. Upper Respiratory Tract Infection Risk - Saxena RC, Singh R, Kumar P, Yadav SC, Negi MP, Saxena VS, Joshua AJ, Vijayabalaji V, Goudar KS, Venkateshwarlu K, Amit AA randomized double blind placebo controlled clinical evaluation of extract of Andrographis paniculata (KalmCold) in patients with uncomplicated upper respiratory tract infectionPhytomedicine.(2010 Mar)
    12. Sore Throat Symptoms - Thamlikitkul V, Dechatiwongse T, Theerapong S, Chantrakul C, Boonroj P, Punkrut W, Ekpalakorn W, Boontaeng N, Taechaiya S, Petcharoen S, et alEfficacy of Andrographis paniculata, Nees for pharyngotonsillitis in adultsJ Med Assoc Thai.(1991 Oct)
    13. Upper Respiratory Tract Infection Risk - Avenell A, Cook JA, Maclennan GS, Macpherson GCVitamin D supplementation to prevent infections: a sub-study of a randomised placebo-controlled trial in older people (RECORD trial, ISRCTN 51647438)Age Ageing.(2007 Sep)
    14. Upper Respiratory Tract Infection Risk - Shimizu Y, Ito Y, Yui K, Egawa K, Orimo HIntake of 25-Hydroxyvitamin D3 Reduces Duration and Severity of Upper Respiratory Tract Infection: A Randomized, Double-Blind, Placebo-Controlled, Parallel Group Comparison StudyJ Nutr Health Aging.(2018)
    15. Upper Respiratory Tract Infection Risk - Murdoch DR, Slow S, Chambers ST, Jennings LC, Stewart AW, Priest PC, Florkowski CM, Livesey JH, Camargo CA, Scragg REffect of vitamin D3 supplementation on upper respiratory tract infections in healthy adults: the VIDARIS randomized controlled trialJAMA.(2012 Oct 3)
    16. Upper Respiratory Tract Infection Risk - Laaksi I, Ruohola JP, Mattila V, Auvinen A, Ylikomi T, Pihlajamäki HVitamin D supplementation for the prevention of acute respiratory tract infection: a randomized, double-blinded trial among young Finnish menJ Infect Dis.(2010 Sep 1)
    17. Upper Respiratory Tract Infection Risk - Bergman P, Norlin AC, Hansen S, Rekha RS, Agerberth B, Björkhem-Bergman L, Ekström L, Lindh JD, Andersson JVitamin D3 supplementation in patients with frequent respiratory tract infections: a randomised and double-blind intervention studyBMJ Open.(2012 Dec 13)
    18. Upper Respiratory Tract Infection Risk - Camargo CA, Sluyter J, Stewart AW, Khaw KT, Lawes CMM, Toop L, Waayer D, Scragg REffect of monthly high-dose vitamin D supplementation on acute respiratory infections in older adults: A randomized controlled trialClin Infect Dis.(2019 Aug 17)
    19. Upper Respiratory Tract Infection Risk - Rees JR, Hendricks K, Barry EL, Peacock JL, Mott LA, Sandler RS, Bresalier RS, Goodman M, Bostick RM, Baron JAVitamin D3 supplementation and upper respiratory tract infections in a randomized, controlled trialClin Infect Dis.(2013 Nov)
    20. Upper Respiratory Tract Infection Risk - Li-Ng M, Aloia JF, Pollack S, Cunha BA, Mikhail M, Yeh J, Berbari NA randomized controlled trial of vitamin D3 supplementation for the prevention of symptomatic upper respiratory tract infectionsEpidemiol Infect.(2009 Oct)
    21. Upper Respiratory Tract Infection Risk - Aglipay M, Birken CS, Parkin PC, Loeb MB, Thorpe K, Chen Y, Laupacis A, Mamdani M, Macarthur C, Hoch JS, Mazzulli T, Maguire JL, TARGet Kids! CollaborationEffect of High-Dose vs Standard-Dose Wintertime Vitamin D Supplementation on Viral Upper Respiratory Tract Infections in Young Healthy ChildrenJAMA.(2017 Jul 18)
    22. Upper Respiratory Tract Infection Risk - Goodall EC, Granados AC, Luinstra K, Pullenayegum E, Coleman BL, Loeb M, Smieja MVitamin D3 and gargling for the prevention of upper respiratory tract infections: a randomized controlled trialBMC Infect Dis.(2014 May 19)
    23. Upper Respiratory Tract Infection Risk - Jung HC, Seo MW, Lee S, Kim SW, Song JKVitamin D₃ Supplementation Reduces the Symptoms of Upper Respiratory Tract Infection during Winter Training in Vitamin D-Insufficient Taekwondo Athletes: A Randomized Controlled TrialInt J Environ Res Public Health.(2018 Sep 14)
    24. Upper Respiratory Tract Infection Risk - Dubnov-Raz G, Rinat B, Hemilä H, Choleva L, Cohen AH, Constantini NWVitamin D supplementation and upper respiratory tract infections in adolescent swimmers: a randomized controlled trialPediatr Exerc Sci.(2015 Feb)
    25. Upper Respiratory Tract Infection Risk - Loeb M, Dang AD, Thiem VD, Thanabalan V, Wang B, Nguyen NB, Tran HTM, Luong TM, Singh P, Smieja M, Maguire J, Pullenayegum EEffect of Vitamin D supplementation to reduce respiratory infections in children and adolescents in Vietnam: A randomized controlled trialInfluenza Other Respir Viruses.(2019 Mar)
    26. Upper Respiratory Tract Infection Risk - Prasad AS, Beck FW, Bao B, Fitzgerald JT, Snell DC, Steinberg JD, Cardozo LJZinc supplementation decreases incidence of infections in the elderly: effect of zinc on generation of cytokines and oxidative stressAm J Clin Nutr.(2007 Mar)
    27. Upper Respiratory Tract Infection Symptoms - Smith DS, Helzner EC, Nuttall CE Jr, Collins M, Rofman BA, Ginsberg D, Goswick CB, Magner AFailure of zinc gluconate in treatment of acute upper respiratory tract infectionsAntimicrob Agents Chemother.(1989 May)
    28. Upper Respiratory Tract Infection Risk - Meydani SN, Leka LS, Fine BC, Dallal GE, Keusch GT, Singh MF, Hamer DHVitamin E and respiratory tract infections in elderly nursing home residents: a randomized controlled trialJAMA.(2004 Aug 18)
    29. Upper Respiratory Tract Infection Risk - Brinkworth GD, Buckley JDConcentrated bovine colostrum protein supplementation reduces the incidence of self-reported symptoms of upper respiratory tract infection in adult malesEur J Nutr.(2003 Aug)
    30. Upper Respiratory Tract Infection Risk - Crooks C, Cross ML, Wall C, Ali AEffect of bovine colostrum supplementation on respiratory tract mucosal defenses in swimmersInt J Sport Nutr Exerc Metab.(2010 Jun)
    31. Upper Respiratory Tract Infection Symptoms - Patıroğlu T, Kondolot MThe effect of bovine colostrum on viral upper respiratory tract infections in children with immunoglobulin A deficiencyClin Respir J.(2013 Jan)
    32. Upper Respiratory Tract Infection Risk - Gleeson M, Bishop NC, Oliveira M, Tauler PDaily probiotic's (Lactobacillus casei Shirota) reduction of infection incidence in athletesInt J Sport Nutr Exerc Metab.(2011 Feb)
    33. Upper Respiratory Tract Infection Risk - Tiollier E, Chennaoui M, Gomez-Merino D, Drogou C, Filaire E, Guezennec CYEffect of a probiotics supplementation on respiratory infections and immune and hormonal parameters during intense military trainingMil Med.(2007 Sep)
    34. Upper Respiratory Tract Infection Risk - Melchart D, Walther E, Linde K, Brandmaier R, Lersch CEchinacea root extracts for the prevention of upper respiratory tract infections: a double-blind, placebo-controlled randomized trialArch Fam Med.(1998 Nov-Dec)
    35. Upper Respiratory Tract Infection Risk - Grimm W, Müller HHA randomized controlled trial of the effect of fluid extract of Echinacea purpurea on the incidence and severity of colds and respiratory infectionsAm J Med.(1999 Feb)
    36. Upper Respiratory Tract Infection Risk - Hall H, Fahlman MM, Engels HJEchinacea purpurea and mucosal immunityInt J Sports Med.(2007 Sep)
    37. Upper Respiratory Tract Infection Risk - Taylor JA, Weber W, Standish L, Quinn H, Goesling J, McGann M, Calabrese CEfficacy and safety of echinacea in treating upper respiratory tract infections in children: a randomized controlled trialJAMA.(2003 Dec 3)
    38. Upper Respiratory Tract Infection Risk - O'Neil J, Hughes S, Lourie A, Zweifler JEffects of echinacea on the frequency of upper respiratory tract symptoms: a randomized, double-blind, placebo-controlled trialAnn Allergy Asthma Immunol.(2008 Apr)
    39. Upper Respiratory Tract Infection Symptoms - Dorn M, Knick E, Lewith GPlacebo-controlled, double-blind study of Echinaceae pallidae radix in upper respiratory tract infectionsComplement Ther Med.()
    40. Upper Respiratory Tract Infection Risk - Zhong K, Liu Z, Lu Y, Xu XEffects of yeast β-glucans for the prevention and treatment of upper respiratory tract infection in healthy subjects: a systematic review and meta-analysis.Eur J Nutr.(2021 Dec)
    41. Upper Respiratory Tract Infection Risk - Indolfi C, Mignini C, Valitutti F, Bizzarri I, Dinardo G, Klain A, Miraglia Del Giudice M, Di Cara GEffects of Nasal Solution Incorporating Resveratrol and Carboxymethyl-Β-Glucan in Preschool Non-Atopic Children with Wheezing.Nutrients.(2024 Jul 10)
    42. Upper Respiratory Tract Infection Symptoms - Hibatullah Abuelgasim, Charlotte Albury, Joseph LeeEffectiveness of honey for symptomatic relief in upper respiratory tract infections: a systematic review and meta-analysisBMJ Evid Based Med.(2020 Aug 18)
    43. Upper Respiratory Tract Infection Symptoms - Hawkins J, Baker C, Cherry L, Dunne EBlack elderberry (Sambucus nigra) supplementation effectively treats upper respiratory symptoms: A meta-analysis of randomized, controlled clinical trials.Complement Ther Med.(2019-Feb)
    44. Pain - Schachtel BP, Voelker M, Sanner KM, Gagney D, Bey M, Schachtel EJ, Becka MDemonstration of the analgesic efficacy and dose-response of acetylsalicylic acid with pseudoephedrineJ Clin Pharmacol.(2010 Dec)
    45. Heart Rate - Eccles R, Jawad MS, Jawad SS, Angello JT, Druce HMEfficacy and safety of single and multiple doses of pseudoephedrine in the treatment of nasal congestion associated with common coldAm J Rhinol.(2005 Jan-Feb)