Folic acid does seem to have anti-inflammatory effects, likely by reducing levels of homocysteine. Research suggests that folic acid supplementation may reduce C-reactive protein and TNF-alpha in a variety of populations including people with metabolic syndrome and type 2 diabetes.[1][2][3] However, most studies have been small and the clinical relevance of this effect isn’t clear.[2]
Does folic acid improve inflammation?
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•Last Updated: May 16, 2025
Folic acid appears to have anti-inflammatory effects by lowering homocysteine levels and may reduce C-reactive protein and TNF-alpha in various populations, including people with metabolic syndrome and type 2 diabetes. However, most studies have been small, and the clinical significance of these effects remains unclear.