A number of supplements, such as myo-inositol, calcium, vitamin E, vitamin D, St. John's Wort, saffron, magnesium, fish oil, curcumin, vitamin B6, vitex agnus-castus (chaste tree), and evening primrose oil, have been studied for premenstrual symptoms.[1][2] Most are only effective for mild to moderate symptoms, when used in combination with other therapies, or to correct nutritional deficiencies.[3] In fact, compared to PMS, there are few trials specific to supplements for PMDD. Chaste tree is perhaps the most well-studied, and although some trials find that it reduces PMDD symptoms, the quality of available evidence is low[4], and it may not be as effective for psychological symptoms as antidepressants.[5]
Have any supplements been studied for premenstrual dysphoric disorder?
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•Last Updated: May 16, 2025
Several supplements — including chaste tree, calcium, and vitamin D — have been studied for premenstrual dysphoric disorder, but most are only effective for mild to moderate symptoms and often require combination with other therapies. Chaste tree is the most researched, though the evidence supporting its effectiveness is low, particularly for psychological symptoms, compared to antidepressants.