Examine Database: Eicosapentaenoic Acid

Health Condition/Goal	Health Outcome	Evidence
Cardiovascular Disease	3 outcomes	16 Studies
Depression	1 outcome	1 Study
High Blood Pressure	10 outcomes	1 Study
High Cholesterol	10 outcomes	3 Studies
Type 2 Diabetes	10 outcomes	2 Studies
General Cardiovascular Health	1 outcome	1 Study
Metabolic Health	3 outcomes	1 Study
Skin Cancer	3 outcomes	1 Study
Skin Health	3 outcomes	1 Study

Cardiovascular Disease

3 outcomes

1 outcome

10 outcomes

10 outcomes

10 outcomes

General Cardiovascular Health

1 outcome

Metabolic Health

3 outcomes

Skin Cancer

3 outcomes

Skin Health

3 outcomes

Cardiovascular Disease

General Cardiovascular Health

Metabolic Health

Skin Cancer

Skin Health

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Supplemental EPA during head and neck cancer treatment

In this 26-week randomized controlled trial in 54 adults who were receiving treatment for head and neck cancer, supplementation with eicosapentaenoic acid (EPA) did not prevent weight loss or improve body composition in comparison with placebo.

EPA may improve outcomes in burn patients

EPA may be more effective alone than combined with DHA for cardiovascular disease mortality risk

The role of fatty acids in the risk of hip fracture

Does fish oil improve muscular endurance?

Update History

Examine Database update
minor

Examine Database References

All-Cause Mortality - Safi U Khan, Ahmad N Lone, Muhammad Shahzeb Khan, Salim S Virani, Roger S Blumenthal, Khurram Nasir, Michael Miller, Erin D Michos, Christie M Ballantyne, William E Boden, Deepak L BhattEffect of omega-3 fatty acids on cardiovascular outcomes: A systematic review and meta-analysisEClinicalMedicine.(2021 Jul 8)
Cardiovascular Disease Mortality - Sheppard JP, Palatnic L, Lakshmanan S, Drago T, Bhogal J, Roy SK, Bhatt DL, Budoff MJ, Nelson JREffects of Eicosapentaenoic Acid vs Eicosapentaenoic/Docosahexaenoic Acids on Cardiovascular Mortality: Meta-Analysis of Clinical Trials.JACC Adv.(2025 Sep 19)
Blood glucose - Woodman RJ, Mori TA, Burke V, Puddey IB, Watts GF, Beilin LJEffects of purified eicosapentaenoic and docosahexaenoic acids on glycemic control, blood pressure, and serum lipids in type 2 diabetic patients with treated hypertensionAm J Clin Nutr.(2002 Nov)
Depression Symptoms - Nemets B, Stahl Z, Belmaker RHAddition of omega-3 fatty acid to maintenance medication treatment for recurrent unipolar depressive disorderAm J Psychiatry.(2002 Mar)
DNA Damage - Rhodes LE, Shahbakhti H, Azurdia RM, Moison RM, Steenwinkel MJ, Homburg MI, Dean MP, McArdle F, Beijersbergen van Henegouwen GM, Epe B, Vink AAEffect of eicosapentaenoic acid, an omega-3 polyunsaturated fatty acid, on UVR-related cancer risk in humans. An assessment of early genotoxic markersCarcinogenesis.(2003 May)
Depression Symptoms - Kiecolt-Glaser JK, Belury MA, Andridge R, Malarkey WB, Hwang BS, Glaser ROmega-3 supplementation lowers inflammation in healthy middle-aged and older adults: a randomized controlled trialBrain Behav Immun.(2012 Aug)

Eicosapentaenoic Acid

Examine Database: Eicosapentaenoic Acid

Research FeedRead all studies

Update History

Examine Database updateminor

Examine Database References

Examine Database: Eicosapentaenoic Acid

Examine Database References

Research FeedRead all studies

Examine Database update
minor