Arterial Stiffness

    Last Updated: October 13, 2024

    Increased arterial stiffness, or the reduced ability of an artery to contract and expand as blood moves through it, is independently linked to increased CVD risk. It is often assessed by measuring pulse wave velocity, which is the time it takes for the heartbeat-induced wave in arterial walls to travel between two arterial points. Faster travel between those two points means the arteries the wave is traveling through are stiffer.

    examine-databaseExamine Database
    3,229 participants in 28 trials

    Examine Database: Arterial Stiffness

    Research FeedRead all studies

    Examine Database References

    1. Spirulina - Miczke A, Szulińska M, Hansdorfer-Korzon R, Kręgielska-Narożna M, Suliburska J, Walkowiak J, Bogdański PEffects of spirulina consumption on body weight, blood pressure, and endothelial function in overweight hypertensive Caucasians: a double-blind, placebo-controlled, randomized trialEur Rev Med Pharmacol Sci.(2016)
    2. Cocoa Extract - Charalambos Vlachopoulos, Konstantinos Aznaouridis, Nikolaos Alexopoulos, Emmanuel Economou, Ioanna Andreadou, Christodoulos StefanadisEffect of dark chocolate on arterial function in healthy individualsAm J Hypertens.(2005 Jun)
    3. Citrulline - Marcos Angel Sanchez-Gonzalez, Andrew Paul Koutnik, Katherine Ramirez, Alexei Wong, Arturo FigueroaThe effects of short term L-citrulline supplementation on wave reflection responses to cold exposure with concurrent isometric exerciseAm J Hypertens.(2013 Apr)
    4. Garlic - Budoff MJ, Takasu J, Flores FR, Niihara Y, Lu B, Lau BH, Rosen RT, Amagase HInhibiting progression of coronary calcification using Aged Garlic Extract in patients receiving statin therapy: a preliminary studyPrev Med.(2004 Nov)
    5. Cocoa Extract - West SG, McIntyre MD, Piotrowski MJ, Poupin N, Miller DL, Preston AG, Wagner P, Groves LF, Skulas-Ray ACEffects of dark chocolate and cocoa consumption on endothelial function and arterial stiffness in overweight adultsBr J Nutr.(2014 Feb)
    6. Curcumin - Santos-Parker JR, Strahler TR, Bassett CJ, Bispham NZ, Chonchol MB, Seals DRCurcumin supplementation improves vascular endothelial function in healthy middle-aged and older adults by increasing nitric oxide bioavailability and reducing oxidative stressAging (Albany NY).(2017 Jan 3)
    7. Curcumin - Nieman DC, Cialdella-Kam L, Knab AM, Shanely RAInfluence of red pepper spice and turmeric on inflammation and oxidative stress biomarkers in overweight females: a metabolomics approachPlant Foods Hum Nutr.(2012 Dec)
    8. Astaxanthin - Coombes JS, Sharman JE, Fassett RGAstaxanthin has no effect on arterial stiffness, oxidative stress, or inflammation in renal transplant recipients: a randomized controlled trial (the XANTHIN trial)Am J Clin Nutr.(2016 Jan)
    9. Curcumin - Chuengsamarn S, Rattanamongkolgul S, Phonrat B, Tungtrongchitr R, Jirawatnotai SReduction of atherogenic risk in patients with type 2 diabetes by curcuminoid extract: a randomized controlled trialJ Nutr Biochem.(2014 Feb)
    10. Citrulline - Arturo Figueroa, Stacey Alvarez-Alvarado, Salvador J Jaime, Roy Kalfonl-Citrulline supplementation attenuates blood pressure, wave reflection and arterial stiffness responses to metaboreflex and cold stress in overweight menBr J Nutr.(2016 Jul)
    11. Bacopa Monnieri - Luke A Downey, James Kean, Fiona Nemeh, Angela Lau, Alex Poll, Rebecca Gregory, Margaret Murray, Johanna Rourke, Brigit Patak, Matthew P Pase, Andrea Zangara, Justine Lomas, Andrew Scholey, Con StoughAn acute, double-blind, placebo-controlled crossover study of 320 mg and 640 mg doses of a special extract of Bacopa monnieri (CDRI 08) on sustained cognitive performancePhytother Res.(2013 Sep)
    12. Vitamin E - Rasool AH, Yuen KH, Yusoff K, Wong AR, Rahman ARDose dependent elevation of plasma tocotrienol levels and its effect on arterial compliance, plasma total antioxidant status, and lipid profile in healthy humans supplemented with tocotrienol rich vitamin EJ Nutr Sci Vitaminol (Tokyo).(2006 Dec)
    13. Grape Juice - Siasos G, Tousoulis D, Kokkou E, Oikonomou E, Kollia ME, Verveniotis A, Gouliopoulos N, Zisimos K, Plastiras A, Maniatis K, Stefanadis CFavorable effects of concord grape juice on endothelial function and arterial stiffness in healthy smokersAm J Hypertens.(2014 Jan)
    14. Ketogenic Diet - Keogh JB, Brinkworth GD, Noakes M, Belobrajdic DP, Buckley JD, Clifton PMEffects of weight loss from a very-low-carbohydrate diet on endothelial function and markers of cardiovascular disease risk in subjects with abdominal obesityAm J Clin Nutr.(2008 Mar)
    15. Red Clover Extract - Nestel PJ, Pomeroy S, Kay S, Komesaroff P, Behrsing J, Cameron JD, West LIsoflavones from red clover improve systemic arterial compliance but not plasma lipids in menopausal womenJ Clin Endocrinol Metab.(1999 Mar)
    16. Garlic - Breithaupt-Grögler K, Ling M, Boudoulas H, Belz GGProtective effect of chronic garlic intake on elastic properties of aorta in the elderlyCirculation.(1997 Oct 21)
    17. Citrulline - Joaquin U Gonzales, Andrea Raymond, John Ashley, Youngdeok KimDoes l-citrulline supplementation improve exercise blood flow in older adults?Exp Physiol.(2017 Dec 1)
    18. Curcumin - Barber-Chamoux N, Milenkovic D, Verny MA, Habauzit V, Pereira B, Lambert C, Richard D, Boby C, Mazur A, Lusson JR, Dubray C, Morand CSubstantial Variability Across Individuals in the Vascular and Nutrigenomic Response to an Acute Intake of Curcumin: A Randomized Controlled TrialMol Nutr Food Res.(2018 Mar)
    19. Citrulline - Arturo Figueroa, Stacey Alvarez-Alvarado, Michael J Ormsbee, Takudzwa A Madzima, Jeremiah C Campbell, Alexei WongImpact of L-citrulline supplementation and whole-body vibration training on arterial stiffness and leg muscle function in obese postmenopausal women with high blood pressureExp Gerontol.(2015 Mar)
    20. Red Clover Extract - Teede HJ, McGrath BP, DeSilva L, Cehun M, Fassoulakis A, Nestel PJIsoflavones reduce arterial stiffness: a placebo-controlled study in men and postmenopausal womenArterioscler Thromb Vasc Biol.(2003 Jun 1)
    21. Curcumin - Sugawara J, Akazawa N, Miyaki A, Choi Y, Tanabe Y, Imai T, Maeda SEffect of endurance exercise training and curcumin intake on central arterial hemodynamics in postmenopausal women: pilot studyAm J Hypertens.(2012 Jun)
    22. Blueberry - Johnson SA, Figueroa A, Navaei N, Wong A, Kalfon R, Ormsbee LT, Feresin RG, Elam ML, Hooshmand S, Payton ME, Arjmandi BHDaily blueberry consumption improves blood pressure and arterial stiffness in postmenopausal women with pre- and stage 1-hypertension: a randomized, double-blind, placebo-controlled clinical trialJ Acad Nutr Diet.(2015 Mar)
    23. Magnesium - Macian N, Dualé C, Voute M, Leray V, Courrent M, Bodé P, Giron F, Sonneville S, Bernard L, Joanny F, Menard K, Ducheix G, Pereira B, Pickering GShort-Term Magnesium Therapy Alleviates Moderate Stress in Patients with Fibromyalgia: A Randomized Double-Blind Clinical Trial.Nutrients.(2022-May-17)
    24. Magnesium - Marques BCAA, Klein MRST, da Cunha MR, de Souza Mattos S, de Paula Nogueira L, de Paula T, Corrêa FM, Oigman W, Neves MFEffects of Oral Magnesium Supplementation on Vascular Function: A Systematic Review and Meta-analysis of Randomized Controlled Trials.High Blood Press Cardiovasc Prev.(2020-Feb)
    25. Sauna - Lee E, Kolunsarka I, Kostensalo J, Ahtiainen JP, Haapala EA, Willeit P, Kunutsor SK, Laukkanen JAEffects of regular sauna bathing in conjunction with exercise on cardiovascular function: a multi-arm, randomized controlled trial.Am J Physiol Regul Integr Comp Physiol.(2022-Sep-01)
    26. Vitamin D - Rajakumar K, Moore CG, Khalid AT, Vallejo AN, Virji MA, Holick MF, Greenspan SL, Arslanian S, Reis SEEffect of vitamin D3 supplementation on vascular and metabolic health of vitamin D-deficient overweight and obese children: a randomized clinical trial.Am J Clin Nutr.(2020-Apr-01)
    27. Whey Protein - Hajizadeh-Sharafabad F, Sharifi Zahabi E, Tarighat-Esfanjani ARole of whey protein in vascular function: a systematic review and meta-analysis of human intervention studies.Br J Nutr.(2022-Aug-28)
    28. Folic Acid (Vitamin B9) - Bokayeva K, Jamka M, Banaszak M, Makarewicz-Bukowska A, Adamczak A, Chrobot M, Janicka A, Jaworska N, Walkowiak JThe Effect of Folic Acid Supplementation on Endothelial Function and Arterial Stiffness Markers in Adults: A Systematic Review and Meta-Analysis.Healthcare (Basel).(2023-Sep-13)