Evidence-based

Bone-specific Alkaline Phosphatase

•Last Updated: October 13, 2024

Bone-specific alkaline phosphatase is an enzyme produced by osteoblasts (bone cells). It is thought to function in calcification of the bone matrix and is a marker of bone health.

Last Updated:October 13, 2024

Research Snapshot

11,695 participants in 5 trials

Examine Evidence Grades

BVitamin K

C2 outcomes

D2 outcomes

Examine Database: Bone-specific Alkaline Phosphatase

Intervention	Grade	Evidence	Effect
Curcumin	D	Participants: 230	No effect
Vitamin K	B	Participants: 332	Small Increase
Black seed	D	Participants: 34	No effect
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Pueraria Mirifica		Participants: 51
Vitamin D		Participants: 8058

Curcumin

No effect

Vitamin K

Small Increase

Black seed

No effect

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Pueraria Mirifica

Vitamin D

Bone-specific Alkaline Phosphatase

Examine Database: Bone-specific Alkaline Phosphatase

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