Creatine Kinase

    Last Updated: October 13, 2024

    Creatine kinase (CK) is an enzyme mainly found in skeletal muscle and the heart. It converts creatine to phosphocreatine, which is used to make ATP. CK is primarily used as a marker of muscle damage. Intense exercise and skeletal muscle disorders can increase CK levels.

    1,066 participants in 25 trials

    Examine Database: Creatine Kinase

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    Examine Database References

    1. L-Carnitine - Khadijeh Parandak, Hamid Arazi, Faegheh Khoshkhahesh, Babak Nakhostin-RoohiThe effect of two-week L-carnitine supplementation on exercise -induced oxidative stress and muscle damageAsian J Sports Med.(2014 Jun)
    2. Rhodiola Rosea - Shanely RA, Nieman DC, Zwetsloot KA, Knab AM, Imagita H, Luo B, Davis B, Zubeldia JMEvaluation of Rhodiola rosea supplementation on skeletal muscle damage and inflammation in runners following a competitive marathonBrain Behav Immun.(2014 Jul)
    3. Rhodiola Rosea - Lin C, et alRhodiola rosea does not reduce in vivo inflammatory activity after continuous endurance exerciseSCI SPORT.()
    4. Citrulline - da Silva DK, Jacinto JL, de Andrade WB, Roveratti MC, Estoche JM, Balvedi MCW, de Oliveira DB, da Silva RA, Aguiar AFCitrulline Malate Does Not Improve Muscle Recovery after Resistance Exercise in Untrained Young Adult MenNutrients.(2017 Oct 18)
    5. Saffron - Ghanbari-Niaki A, et alEffect of Crocus Sativus Linnaeus (saffron) supplementations combined with circuit resistance training on total creatine kinase, lactate dehydrogenase and creatine kinase MB levels in young untrained menScience & Sports.()
    6. Panax Ginseng (Korean Ginseng) - Yi-Ming Chen, I-Lin Wang, Shu Zhou, Tsung-Yu Tsai, Yen-Shuo Chiu, Wan-Chun ChiuSix weeks of Jilin ginseng root supplementation attenuates drop jump-related muscle injury markers in healthy female college studentsFood Funct.(2021 Mar 1)
    7. L-Carnitine - M A Giamberardino, L Dragani, R Valente, F Di Lisa, R Saggini, L VecchietEffects of prolonged L-carnitine administration on delayed muscle pain and CK release after eccentric effortInt J Sports Med.(1996 Jul)
    8. Kefir - Ghizi ACdS et alKefir improves blood parameters and reduces cardiovascular risks in patients with metabolic syndromePharmaNutrition.()
    9. Spirulina - Hsueh-Kuan Lu, Chin-Cheng Hsieh, Jen-Jung Hsu, Yuh-Kuan Yang, Hong-Nong ChouPreventive effects of Spirulina platensis on skeletal muscle damage under exercise-induced oxidative stressEur J Appl Physiol.(2006 Sep)
    10. Rhodiola Rosea - Jówko E, Sadowski J, Długołęcka B, Gierczuk D, Opaszowski B, Cieśliński IEffects of Rhodiola rosea supplementation on mental performance, physical capacity, and oxidative stress biomarkers in healthy menJ Sport Health Sci.(2018 Oct)
    11. Coenzyme Q10 - Serag H, El Wakeel L, Adly ACoenzyme Q10 administration has no effect on sICAM-1 and metabolic parameters of pediatrics with type 1 diabetes mellitusInt J Vitam Nutr Res.(2020 Jan 16)
    12. Tart Cherry Juice - Bell PG, Stevenson E, Davison GW, Howatson GThe Effects of Montmorency Tart Cherry Concentrate Supplementation on Recovery Following Prolonged, Intermittent ExerciseNutrients.(2016 Jul 22)
    13. Tart Cherry Juice - Meghan A Brown, Emma J Stevenson, Glyn HowatsonMontmorency tart cherry (Prunus cerasus L.) supplementation accelerates recovery from exercise-induced muscle damage in femalesEur J Sport Sci.(2019 Feb)
    14. Tart Cherry Juice - Phillip G Bell, Ian H Walshe, Gareth W Davison, Emma J Stevenson, Glyn HowatsonRecovery facilitation with Montmorency cherries following high-intensity, metabolically challenging exerciseAppl Physiol Nutr Metab.(2015 Apr)
    15. Tart Cherry Juice - Bowtell JL, Sumners DP, Dyer A, Fox P, Mileva KNMontmorency cherry juice reduces muscle damage caused by intensive strength exerciseMed Sci Sports Exerc.(2011 Aug)
    16. Tart Cherry Juice - Quinlan R, Hill JAThe Efficacy of Tart Cherry Juice in Aiding Recovery After Intermittent Exercise.Int J Sports Physiol Perform.(2019-Oct-15)
    17. Tart Cherry Juice - Bell PG, Walshe IH, Davison GW, Stevenson E, Howatson GMontmorency cherries reduce the oxidative stress and inflammatory responses to repeated days high-intensity stochastic cyclingNutrients.(2014 Feb 21)
    18. Tart Cherry Juice - Wangdi JT, O'Leary MF, Kelly VG, Jackman SR, Tang JCY, Dutton J, Bowtell JLTart Cherry Supplement Enhances Skeletal Muscle Glutathione Peroxidase Expression and Functional Recovery after Muscle Damage.Med Sci Sports Exerc.(2022-Apr-01)
    19. Tart Cherry Juice - Lamb KL, Ranchordas MK, Johnson E, Denning J, Downing F, Lynn ANo Effect of Tart Cherry Juice or Pomegranate Juice on Recovery from Exercise-Induced Muscle Damage in Non-Resistance Trained Men.Nutrients.(2019-Jul-14)
    20. Magnesium - Steward CJ, Zhou Y, Keane G, Cook MD, Liu Y, Cullen TOne week of magnesium supplementation lowers IL-6, muscle soreness and increases post-exercise blood glucose in response to downhill running.Eur J Appl Physiol.(2019-Dec)
    21. Magnesium - Córdova A, Mielgo-Ayuso J, Roche E, Caballero-García A, Fernandez-Lázaro DImpact of Magnesium Supplementation in Muscle Damage of Professional Cyclists Competing in a Stage Race.Nutrients.(2019-Aug-16)
    22. Tongkat Ali - Henkel RR, Wang R, Bassett SH, Chen T, Liu N, Zhu Y, Tambi MITongkat Ali as a potential herbal supplement for physically active male and female seniors--a pilot study.Phytother Res.(2014-Apr)
    23. Creatine - Yue Jiaming, Mohammad Hossein RahimiCreatine supplementation effect on recovery following exercise-induced muscle damage: A systematic review and meta-analysis of randomized controlled trialsJ Food Biochem.(2021 Oct)
    24. Creatine - Bethany Northeast, Tom CliffordThe Effect of Creatine Supplementation on Markers of Exercise-Induced Muscle Damage: A Systematic Review and Meta-Analysis of Human Intervention TrialsInt J Sport Nutr Exerc Metab.(2021 Feb 24)
    25. Curcumin - Liu X, Lin L, Hu GMeta-analysis of the effect of curcumin supplementation on skeletal muscle damage status.PLoS One.(2024)