Evidence-based

Ketone Bodies

•Last Updated: March 27, 2025

Ketone bodies are small molecules that are produced in higher amounts during states of carbohydrate depletion, and are known to contribute to energy metabolism and may influence other aspects of the body.

Last Updated:March 27, 2025

Research Snapshot

3,918 participants in 22 trials

Examine Evidence Grades

AKetogenic Diet + 1 more

BExogenous Ketones + 1 more

C3 outcomes

D2 outcomes

Examine Database: Ketone Bodies

Intervention	Grade	Evidence	Effect
Exogenous Ketones	B	Participants: 586	Large Increase
Ketogenic Diet	A	Participants: 461	Large Increase
Medium-chain Triglycerides	A	Participants: 246	Moderate Increase
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Sodium Bicarbonate		Participants: 24
L-Carnitine		Participants: 19
Branched-Chain Amino Acids		Participants: 7
Niacin (Vitamin B3)		Participants: 12
Fish Oil		Participants: 20
Colostrum		Participants: 16

Exogenous Ketones