Major Adverse Cardiac Events (MACE)

    Written by:
    Katie Jantz
    Last Updated: November 15, 2023

    Major adverse cardiac events (MACE), also known as major adverse cardiovascular events, is an umbrella term that represents a variety of severe cardiovascular outcomes. There is no standardized definition of MACE and it varies between studies, but it can include nonfatal heart attack, nonfatal stroke, cardiovascular mortality, all-cause mortality, unstable angina, heart failure, and unplanned coronary revascularization. MACE is used as a composite endpoint in research to help evaluate the effectiveness of an intervention in preventing serious cardiovascular events.

    185,259 participants in 4 trials

    Examine Database: Major Adverse Cardiac Events (MACE)

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    Examine Database References

    1. Alpha-Linolenic Acid (ALA) - Asmaa S Abdelhamid, Tracey J Brown, Julii S Brainard, Priti Biswas, Gabrielle C Thorpe, Helen J Moore, Katherine Ho Deane, Carolyn D Summerbell, Helen V Worthington, Fujian Song, Lee HooperOmega-3 fatty acids for the primary and secondary prevention of cardiovascular diseaseCochrane Database Syst Rev.(2020 Feb 29)
    2. Folic Acid (Vitamin B9) - Wang WW, Wang XS, Zhang ZR, He JC, Xie CLA Meta-Analysis of Folic Acid in Combination with Anti-Hypertension Drugs in Patients with Hypertension and Hyperhomocysteinemia.Front Pharmacol.(2017)
    3. Fish Oil - Safi U Khan, Ahmad N Lone, Muhammad Shahzeb Khan, Salim S Virani, Roger S Blumenthal, Khurram Nasir, Michael Miller, Erin D Michos, Christie M Ballantyne, William E Boden, Deepak L BhattEffect of omega-3 fatty acids on cardiovascular outcomes: A systematic review and meta-analysisEClinicalMedicine.(2021 Jul 8)
    4. Vitamin E - Lonn E, Bosch J, Yusuf S, Sheridan P, Pogue J, Arnold JM, Ross C, Arnold A, Sleight P, Probstfield J, Dagenais GR, HOPE and HOPE-TOO Trial InvestigatorsEffects of long-term vitamin E supplementation on cardiovascular events and cancer: a randomized controlled trialJAMA.(2005 Mar 16)