African mango supplements are claimed to cause weight loss and improve aspects of metabolic syndrome by affecting total cholesterol, LDL-C, and blood glucose.[1][2][3] While systematic reviews conclude that African mango supplements might cause these beneficial effects,[4][5] these reviews also conclude that the evidence has a high risk of bias because of poor reporting quality and serious methodological problems. including unclear randomization and blinding protocols, and the inclusion of lifestyle modifications in addition to supplementation.[4][5] Therefore, high-quality randomized controlled trials are needed to determine whether African mango supplements are useful for weight loss or the treatment of metabolic syndrome.
Other evidence shows that Irvingia gabonensis extracts can reduce organ toxicity caused by certain drugs used to treat cancer, such as doxorubicin and trastuzumab.[6][7] However, these effects have only been shown in rodent experiments and require verification in humans.