Alanylglutamine
•Last Updated: September 28 2022
Alanylglutamine is most often used for
Last Updated: September 28 2022
L-Alanyl-L-Glutamine (alanylglutamine) is a dipeptide molecule, consisting of L-glutamine and L-alanine, two amino acids.
Alanylglutamine is sometimes supplemented before prolonged physical exercise to enhance electrolyte absorption and improve endurance.
Preliminary rodent evidence suggests alanylglutamine is more effective at increasing muscular glutamine content after supplementation than glutamine itself. This is because glutamine is absorbed by the liver and intestines after supplementation. Since alanylglutamine is a dipeptide molecule, it contains more than one amino acid for the intestines to absorb, allowing glutamine to reach the muscles.
Though alanylglutamine supplementation results in greater glutamine muscular content, this has not been shown to provide a performance enhancing effect.
Current evidence suggests alanylglutamine may be a more effective supplement than glutamine because of its increased stability and water solubility, but more research is needed to determine if it actually has an effect on performance.
Note that Alanylglutamine is also known as:
- L-Alanyl-L-Glutamine
- Alanyl-Glutamine
- Sustamine (brand name)
Alanylglutamine should not be confused with:
Current studies on L-alanyl-L-glutamine use a dose of 1-3g a day. More research is needed to determine the optimal dose.
L-Alanyl-L-Glutamine supplementation may be similar to glutamine supplementation, in terms of dose, timing, and purpose.
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1.^Hirao Y1, Mihara Y, Kira I, Abe I, Yokozeki KEnzymatic production of L-alanyl-L-glutamine by recombinant E. coli expressing α-amino acid ester acyltransferase from Sphingobacterium siyangensisBiosci Biotechnol Biochem.(2013)
2.^Tabata K1, Hashimoto SFermentative production of L-alanyl-L-glutamine by a metabolically engineered Escherichia coli strain expressing L-amino acid alpha-ligaseAppl Environ Microbiol.(2007 Oct)
4.^Harris RC1, Hoffman JR, Allsopp A, Routledge NBL-glutamine absorption is enhanced after ingestion of L-alanylglutamine compared with the free amino acid or wheat proteinNutr Res.(2012 Apr)
5.^Lima AA1, Carvalho GH, Figueiredo AA, Gifoni AR, Soares AM, Silva EA, Guerrant RLEffects of an alanyl-glutamine-based oral rehydration and nutrition therapy solution on electrolyte and water absorption in a rat model of secretory diarrhea induced by cholera toxinNutrition.(2002 Jun)
6.^Hoffman JR1, Ratamess NA, Kang J, Rashti SL, Kelly N, Gonzalez AM, Stec M, Anderson S, Bailey BL, Yamamoto LM, Hom LL, Kupchak BR, Faigenbaum AD, Maresh CMExamination of the efficacy of acute L-alanyl-L-glutamine ingestion during hydration stress in endurance exerciseJ Int Soc Sports Nutr.(2010 Feb 3)
8.^Adibi SAThe oligopeptide transporter (Pept-1) in human intestine: biology and functionGastroenterology.(1997 Jul)
9.^Alteheld B1, Evans ME, Gu LH, Ganapathy V, Leibach FH, Jones DP, Ziegler TRAlanylglutamine dipeptide and growth hormone maintain PepT1-mediated transport in oxidatively stressed Caco-2 cellsJ Nutr.(2005 Jan)
10.^Ford D1, Howard A, Hirst BHExpression of the peptide transporter hPepT1 in human colon: a potential route for colonic protein nitrogen and drug absorptionHistochem Cell Biol.(2003 Jan)
11.^Haque SM1, Chen K, Usui N, Iiboshi Y, Okuyama H, Masunari A, Cui L, Nezu R, Takagi Y, Okada AAlanyl-glutamine dipeptide-supplemented parenteral nutrition improves intestinal metabolism and prevents increased permeability in ratsAnn Surg.(1996 Mar)
12.^Tazuke Y1, Wasa M, Shimizu Y, Wang HS, Okada AAlanyl-glutamine-supplemented parenteral nutrition prevents intestinal ischemia-reperfusion injury in ratsJPEN J Parenter Enteral Nutr.(2003 Mar-Apr)
13.^Petry ER1, Cruzat VF2, Heck TG3, Leite JS1, Homem de Bittencourt PI Jr4, Tirapegui J1Alanyl-glutamine and glutamine plus alanine supplements improve skeletal redox status in trained rats: involvement of heat shock protein pathwaysLife Sci.(2014 Jan 17)
14.^Cruzat VF1, Rogero MM, Tirapegui JEffects of supplementation with free glutamine and the dipeptide alanyl-glutamine on parameters of muscle damage and inflammation in rats submitted to prolonged exerciseCell Biochem Funct.(2010 Jan)
15.^Cruzat VF1, Tirapegui JEffects of oral supplementation with glutamine and alanyl-glutamine on glutamine, glutamate, and glutathione status in trained rats and subjected to long-duration exerciseNutrition.(2009 Apr)
16.^Rogero MM1, Tirapegui J, Pedrosa RG, Castro IA, Pires ISEffect of alanyl-glutamine supplementation on plasma and tissue glutamine concentrations in rats submitted to exhaustive exerciseNutrition.(2006 May)
17.^Wagenmakers AJMuscle amino acid metabolism at rest and during exercise: role in human physiology and metabolismExerc Sport Sci Rev.(1998)
18.^Wagenmakers AJ1, Beckers EJ, Brouns F, Kuipers H, Soeters PB, van der Vusse GJ, Saris WHCarbohydrate supplementation, glycogen depletion, and amino acid metabolism during exerciseAm J Physiol.(1991 Jun)
19.^Lochs H1, Roth E, Gasic S, Hübl W, Morse EL, Adibi SASplanchnic, renal, and muscle clearance of alanylglutamine in man and organ fluxes of alanine and glutamine when infused in free and peptide formsMetabolism.(1990 Aug)
20.^Satoh S1, Kusunoki C, Konta Y, Niwa M, Kohsaka MCloning and structural analysis of genomic DNA for human renal dipeptidaseBiochim Biophys Acta.(1993 Feb 20)
21.^Satoh S1, Ohtsuka K, Keida Y, Kusunoki C, Konta Y, Niwa M, Kohsaka MGene structural analysis and expression of human renal dipeptidaseBiotechnol Prog.(1994 Mar-Apr)
22.^Wang W, Choi RH, Solares GJ, Tseng HM, Ding Z, Kim K, Ivy JLL-Alanylglutamine inhibits signaling proteins that activate protein degradation, but does not affect proteins that activate protein synthesis after an acute resistance exerciseAmino Acids.(2015 Jul)
23.^Cai D, Frantz JD, Tawa NE Jr, Melendez PA, Oh BC, Lidov HG, Hasselgren PO, Frontera WR, Lee J, Glass DJ, Shoelson SEIKKbeta/NF-kappaB activation causes severe muscle wasting in miceCell.(2004 Oct 15)
24.^Nakashima K, Yakabe YAMPK activation stimulates myofibrillar protein degradation and expression of atrophy-related ubiquitin ligases by increasing FOXO transcription factors in C2C12 myotubesBiosci Biotechnol Biochem.(2007 Jul)
25.^Kelley PM, Schlesinger MJThe effect of amino acid analogues and heat shock on gene expression in chicken embryo fibroblastsCell.(1978 Dec)
26.^Lemaux PG, Herendeen SL, Bloch PL, Neidhardt FCTransient rates of synthesis of individual polypeptides in E. coli following temperature shiftsCell.(1978 Mar)
27.^McAlister L, Finkelstein DBHeat shock proteins and thermal resistance in yeastBiochem Biophys Res Commun.(1980 Apr 14)
28.^Richter K1, Haslbeck M, Buchner JThe heat shock response: life on the verge of deathMol Cell.(2010 Oct 22)
29.^Liu Y1, Lormes W, Baur C, Opitz-Gress A, Altenburg D, Lehmann M, Steinacker JMHuman skeletal muscle HSP70 response to physical training depends on exercise intensityInt J Sports Med.(2000 Jul)
30.^Hoffman JR1, Williams DR, Emerson NS, Hoffman MW, Wells AJ, McVeigh DM, McCormack WP, Mangine GT, Gonzalez AM, Fragala MSL-alanyl-L-glutamine ingestion maintains performance during a competitive basketball gameJ Int Soc Sports Nutr.(2012 Mar 7)
31.^Dougherty KA1, Baker LB, Chow M, Kenney WLTwo percent dehydration impairs and six percent carbohydrate drink improves boys basketball skillsMed Sci Sports Exerc.(2006 Sep)
32.^Hoffman JR1, Stavsky H, Falk BThe effect of water restriction on anaerobic power and vertical jumping height in basketball playersInt J Sports Med.(1995 May)
33.^Baker LB1, Dougherty KA, Chow M, Kenney WLProgressive dehydration causes a progressive decline in basketball skill performanceMed Sci Sports Exerc.(2007 Jul)
34.^Leite RD1, Lima NL, Leite CA, Farhat CK, Guerrant RL, Lima AAImprovement of intestinal permeability with alanyl-glutamine in HIV patients: a randomized, double blinded, placebo-controlled clinical trialArq Gastroenterol.(2013 Jan-Mar)
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