Alpha-GPC

    Written by:
    Mike Murray, Megan Michaux

    Fact-checked

    by:

    Nick Milazzo, Gregory Lopez
    Last Updated: September 4, 2025

    Alpha-glycerylphosphorylcholine (alpha-GPC or α-GPC) is a compound used by the body in the synthesis of neurotransmitters. It is taken as a supplement for cognitive enhancement/prevention of cognitive decline and for increased power output in athletic performance.

    Overview

    Dosage Information

    For attenuating symptoms of cognitive decline, almost all studies used a dosage of 1,200 mg per day, divided into three doses of 400 mg.

    For boosting power output, studies have used a dosage of 300–600 mg, supplemented 30–60 minutes prior to exercise.

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    Research Breakdown