Alpha-GPC

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    Mike Murray, Megan Michaux

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    Nick Milazzo, Gregory Lopez
    Last Updated: September 4, 2025

    Alpha-glycerylphosphorylcholine (alpha-GPC or α-GPC) is a compound used by the body in the synthesis of neurotransmitters. It is taken as a supplement for cognitive enhancement/prevention of cognitive decline and for increased power output in athletic performance.

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    Overview

    Dosage information

    For attenuating symptoms of cognitive decline, almost all studies used a dosage of 1,200 mg per day, divided into three doses of 400 mg.

    For boosting power output, studies have used a dosage of 300–600 mg, supplemented 30–60 minutes prior to exercise.

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    Frequently asked questions

    Update History

    Research Breakdown

    Examine Database References

    1. Alzheimer's Disease Symptoms - De Jesus Moreno Moreno MCognitive improvement in mild to moderate Alzheimer's dementia after treatment with the acetylcholine precursor choline alfoscerate: a multicenter, double-blind, randomized, placebo-controlled trialClin Ther.(2003 Jan)
    2. Growth Hormone - Tim Ziegenfuss, Jamie Landis and Jennifer HofheinsAcute supplementation with alpha-glycerylphosphorylcholine augments growth hormone response to, and peak force production during, resistance exerciseJISSN.()
    3. Growth Hormone - Kawamura T, Okubo T, Sato K, Fujita S, Goto K, Hamaoka T, Iemitsu MGlycerophosphocholine enhances growth hormone secretion and fat oxidation in young adultsNutrition.(2012 Jun 5)
    4. Iron Absorption - Charlotte N Armah, Paul Sharp, Fred A Mellon, Sandra Pariagh, Elizabeth K Lund, Jack R Dainty, Birgit Teucher, Susan J Fairweather-TaitL-alpha-glycerophosphocholine contributes to meat's enhancement of nonheme iron absorptionJ Nutr.(2008 May)
    5. Iron Absorption - Troesch B, Egli I, Zeder C, Hurrell RF, de Pee S, Zimmermann MBOptimization of a phytase-containing micronutrient powder with low amounts of highly bioavailable iron for in-home fortification of complementary foodsAm J Clin Nutr.(2009 Feb)