Capsaicin

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    Last Updated: March 4, 2024

    Capsaicin is a molecule found in hot peppers that creates the sensation of spiciness by activating the heat receptor TRPV1. Ingestion of capsaicin may improve exercise performance, but it appears mostly ineffective for fat loss. When applied topically, capsaicin can reduce pain.

    Overview

    Dosage information

    Capsaicin/capsaicinoids are typically given in doses ranging from about 1.2 to 12 mg, although some studies have used up to 135 mg per day.[1]

    Capsaicin-containing supplements are usually sold in the form of dried chili pepper powder (e.g, cayenne). A capsule containing 500 mg of dried cayenne pepper contains around 1.2 mg of capsaicin.

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    Update History

    Fixed sample sizes on a handful of meta-analyses

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    Examine Database References

    1. Blood glucose - Chaiyasit K, Khovidhunkit W, Wittayalertpanya SPharmacokinetic and the effect of capsaicin in Capsicum frutescens on decreasing plasma glucose levelJ Med Assoc Thai.(2009 Jan)
    2. Heart Rate - Shin KO, Moritani TAlterations of autonomic nervous activity and energy metabolism by capsaicin ingestion during aerobic exercise in healthy menJ Nutr Sci Vitaminol (Tokyo).(2007 Apr)
    3. Blood Pressure - Yoshioka M, Imanaga M, Ueyama H, Yamane M, Kubo Y, Boivin A, St-Amand J, Tanaka H, Kiyonaga AMaximum tolerable dose of red pepper decreases fat intake independently of spicy sensation in the mouthBr J Nutr.(2004 Jun)
    4. Weight - Zhang W, Zhang Q, Wang L, Zhou Q, Wang P, Qing Y, Sun CThe effects of capsaicin intake on weight loss among overweight and obese subjects: a systematic review and meta-analysis of randomised controlled trials.Br J Nutr.(2023-Nov-14)
    5. Aerobic Exercise Metrics - Effects of Capsaicin and Capsiate on Endurance Performance: A Meta-AnalysisNutrients.(2022-10-28)