Chlorogenic Acid

    Researchedby:
    Kamal Patel
    Last Updated: October 13, 2024

    Chlorogenic acid is found in coffee mostly and a lot of plant compounds; it holds promise in many aspects of health and cognition similar to bioflavonoids and shares some effects similar to caffeine but less potent. May decrease the absorption of dietary carbohydrate.

    Chlorogenic Acid is most often used for Cardiovascular Health. The Examine Database covers Cognitive Improvement, High Blood Pressure, and 4 other conditions and goals.

    375 participants in 5 trials and 1 meta-analysis

    Summary

    Chlorogenic acid is a phytochemical found in coffee and coffee beans. It has been touted as being able to reduce blood sugar levels and potentially exert an anti-diabetic effect. It has also been implicated in weight loss and exerting an anti-obesity effect, but that is insofar correlation and not necessarily due to chlorogenic acid.

    It can be beneficial to supplement, although doses found in food sources are enough for a long-term preventative (anti-diabetic) measure.

    What are other names for Chlorogenic Acid

    Note that Chlorogenic Acid is also known as:
    • Coffee bean extract
    • 5-O-caffeoylquinic acid
    • 3-O-caffeoylquinic acid Green coffee extract
    Chlorogenic Acid should not be confused with:
    • Chlorine
    • Corosolic Acid

    Dosage information

    Supplemental chlorogenic acid appears to have benefit in the range of 120-300mg oral intake, with higher doses still possibly beneficial (not really tested sufficiently). These doses appear to benefit blood pressure and circulation mostly.

    This dose seems to be low enough that moderate to high doses of plants with a rich chlorogenic acid content may confer the benefits listed on this page, this most notably includes green coffee extract.

    Examine Database: Chlorogenic Acid

    Research FeedRead all studies

    Research Breakdown

    Examine Database References

    1. Blood Pressure - Watanabe T, Arai Y, Mitsui Y, Kusaura T, Okawa W, Kajihara Y, Saito IThe blood pressure-lowering effect and safety of chlorogenic acid from green coffee bean extract in essential hypertensionClin Exp Hypertens.(2006 Jul)
    2. Insulin - van Dijk AE, Olthof MR, Meeuse JC, Seebus E, Heine RJ, van Dam RMAcute effects of decaffeinated coffee and the major coffee components chlorogenic acid and trigonelline on glucose toleranceDiabetes Care.(2009 Jun)
    3. Subjective Well-Being - Cropley V, Croft R, Silber B, Neale C, Scholey A, Stough C, Schmitt JDoes coffee enriched with chlorogenic acids improve mood and cognition after acute administration in healthy elderly? A pilot studyPsychopharmacology (Berl).(2012 Feb)
    4. Cognitive Function - Johal K, Jones DJW, Bell L, Lovegrove JA, Lamport DJImpact of coffee-derived chlorogenic acid on cognition: a systematic review and meta-analysis.Nutr Res Rev.(2024 Oct 15)
    5. Homocysteine - Olthof MR, Hollman PC, Zock PL, Katan MBConsumption of high doses of chlorogenic acid, present in coffee, or of black tea increases plasma total homocysteine concentrations in humansAm J Clin Nutr.(2001 Mar)
    6. Weight - Thom EThe effect of chlorogenic acid enriched coffee on glucose absorption in healthy volunteers and its effect on body mass when used long-term in overweight and obese peopleJ Int Med Res.(2007 Nov-Dec)