CoQ10 is a key endogenous antioxidant; however, its production in the body can be affected by age, underlying medical conditions, and other factors. One meta-analysis, involving healthy participants and those with cardiovascular or metabolic disease, revealed that supplementation with 30–500 mg daily of CoQ10 significantly increased total antioxidant capacity (TAC) scores and decreased malondialdehyde (MDA) levels (an oxidative stress marker) compared to the control group, although it did not significantly affect levels of another endogenous antioxidant, superoxide dismutase (SOD).[1]
Another meta-analysis indicated that supplementation with CoQ10 significantly lowered levels of inflammatory markers such as c-reactive protein (CRP), interleukin 6 (IL-6), and tumor necrosis factor alpha (TNF-alpha), suggesting a potential anti-inflammatory effect.[2]
Additionally, CoQ10 demonstrated potential for reduction of migraine and non-migraine headaches in both adults[3] and children aged 6–12 years.[4]
Furthermore, extensive research has explored the cardiovascular and metabolic benefits of CoQ10, yielding promising results. For detailed information on CoQ10's main benefits on cardiovascular and metabolic health, please refer to the question “What are coenzyme Q10’s main benefits on cardiovascular and metabolic health?”
Finally, preliminary evidence suggests that supplementation with CoQ10 (300 mg) may be effective in reducing symptoms associated with fibromyalgia.[5]