Evidence-based

Headaches

•Last Updated: May 21, 2025

Headaches are characterized by pain throughout the head and/or face. The location, intensity, and causes of headaches can vary.

Last Updated:May 21, 2025

Research Snapshot

50,512 participants in 26 trials

Examine Database: Headaches

Intervention	Grade	Evidence	Effect
Umckaloabo	B	Participants: 4364	Small Improvement
Caffeine	B	Participants: 1503	Small Improvement
Relaxation Therapy	B	Participants: 383	Small Improvement
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Niacin (Vitamin B3)		Participants: 300
Bitter Orange		Participants: 81
Mindfulness		Participants: 150
Peppermint		Participants: 73
Lactase Enzyme		Participants: 26
Kefir		Participants: 82
Theanine		Participants: 24
Creatine		Participants: 35
Biofeedback		Participants: 558