Folic acid does seem to have anti-inflammatory effects, likely by reducing levels of homocysteine. Research suggests that folic acid supplementation may reduce C-reactive protein and TNF-alpha in a variety of populations including people with metabolic syndrome and type 2 diabetes.[1][2][3] However, most studies have been small and the clinical relevance of this effect isn’t clear.[2]
References
- ^Fatahi S, Pezeshki M, Mousavi SM, Teymouri A, Rahmani J, Kord Varkaneh H, Ghaedi EEffects of folic acid supplementation on C-reactive protein: A systematic review and meta-analysis of randomized controlled trials.Nutr Metab Cardiovasc Dis.(2019-May)
- ^Zargarzadeh N, Severo JS, Pizarro AB, Persad E, Mousavi SMThe Effects of Folic Acid Supplementation on Pro-inflammatory Mediators: a Systematic Review and Dose-Response Meta-Analysis of Randomized Controlled Trials.Clin Ther.(2021-Dec)
- ^Jiang Z, Qu H, Chen K, Gao ZBeneficial effects of folic acid on inflammatory markers in the patients with metabolic syndrome: Meta-analysis and meta-regression of data from 511 participants in 10 randomized controlled trials.Crit Rev Food Sci Nutr.(2022-Dec-28)