L-Threonate is most often used for
Structure and Sources
L-Threonate is a deriviative of L-ascorbic acid 2-phosphate (which in and of itself is a derivative of Ascorbic Acid, otherwise known as Vitamin C).
Effects on Hair Loss
L-threonate is able to repress the expression of a gene known as dickkopf-1 (DKK-1) which is upregulated by Dihydrotestosterone (DHT) in male pattern baldness when co-cultured. It seems to work similarily to L-ascorbic acid 2-phosphate via alkaline phosphatase activity and releasing ascorbic acid into the cell.
Effects on Bone Metabolism
Independent of its use as a conjugate to Calcium as Calcium-L-Threonate (to be discussed), L-Threonate has been investigated for its usage in bone health. It has been implicated as working synergistically with calcium in the production of collagen and mineralized nodules. and augments the uptake of ascorbic acid into fibroblasts. By itself, L-threonate can also act on osteoclasts in an anti-osteoporotic manner.
Use as a mineral chelation
Safety and Toxicity
The safety and toxicity of L-threonate has not been investigated.