MSM

    Written by:
    Megan Michaux

    Fact-checked

    by:

    Katie Jantz, Conni Covington
    Last Updated: November 5, 2024

    Methylsulfonylmethane (MSM) is an organosulfur compound that is found naturally in fruit, vegetables, and grains. It has anti-inflammatory and antioxidant properties and is most commonly used as a dietary supplement to promote joint health and to alleviate pain in people with osteoarthritis.

    Overview

    Dosage Information

    Formulation

    MSM is available in tablet form, powder form, and in topical creams. The best evidence available is for the tablet form.

    Range of dosages studied

    MSM has been studied in doses ranging from 500 mg per day up to 6 grams per day. These doses have been given over periods ranging from 10 days up to 16 weeks.

    Other considerations

    Even though MSM is sometimes referred to as crystalline dimethyl sulfoxide, it should not be mistaken for dimethyl sulfoxide (DMSO). DMSO is a different compound that can be converted to MSM in the body.[1]

    Frequently Asked Questions

    Update History

    Research Breakdown