Formulation: MSM is available in tablet form, powder form, and in topical creams. The best evidence available is for the tablet form.

Range of dosages studied: MSM has been studied in doses ranging from 500 mg per day up to 6 grams per day. These doses have been given over periods ranging from 10 days up to 12 weeks.^[1][2]

Effective Dosages:

Osteoarthritis

People with osteoarthritis: 2–6 grams per day, taken orally in 3 divided doses.

Special considerations: This should be continued for at least 6 weeks and up to 12 weeks.^[2]

Exercise-induced muscle injury

General Population: The recommendation from the FDA is 3 grams per day for 14 days. However, one study found that MSM taken orally for 10 days at a dose of 50 mg per kg of body weight could reduce muscle damage after exercise.^[3][2]

Knee Pain

General population: 3 grams per day for at least 8 weeks.

Special considerations: This dose is on the lower end of the osteoarthritis dose range and applies to more general pain that is not necessarily from an inflammatory arthritis.^[2]

Allergic Rhinitis

General population: 2.6–5.2 grams/day for up to 44 days.

Special considerations: Studies vary on the recommended dose for allergic rhinitis. Some used 2.6 grams in a single dose, but 3 grams daily over a period of 4 to 6 weeks is most commonly recommended.^[2][4]

Rosacea

General population: Apply a 5% topical cream twice a day for one month.

Special considerations: This dose might also help to reduce the appearance of scars. However, the effectiveness of topical MSM is not as well researched.^[2]

Note: Even though MSM is sometimes referred to as crystalline dimethyl sulfoxide, it should not be mistaken for dimethyl sulfoxide (DMSO). DMSO is a different compound that can be converted to MSM in the body.^[1]