Nattokinase

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    Last Updated: February 27, 2025

    Nattokinase is an enzyme derived from the fermented soy food product nattō which appears to have some direct fibrinolytic (blood-clot-busting) activity. It is thought to have cardioprotective effects.

    Overview

    Dosage information

    Most commonly, 100 mg (2,000 fibrinolytic units (FU)) of nattokinase are taken by mouth daily.[1][2][3][4] This dose is reported to not cause adverse effects by the European Food Safety Authority (EFSA).[5] Limited research using higher doses of nattokinase also reported no adverse effects. People living in China have taken 540 mg (10,800 FU) of nattokinase daily for a year,[6] and adults living in the United States have taken 552 mg of nattokinase daily for four weeks[2] without any reported adverse effects. Nattō itself can be used, and some anti-clotting effects have been noted with 12 grams of nattō daily over 2 weeks.[7]

    Frequently asked questions

    Update History

    Examine Database References

    1. Fibrinolysis - Sumi H, Hamada H, Nakanishi K, Hiratani HEnhancement of the fibrinolytic activity in plasma by oral administration of nattokinaseActa Haematol.(1990)
    2. Factor VIII - Hsia CH, Shen MC, Lin JS, Wen YK, Hwang KL, Cham TM, Yang NCNattokinase decreases plasma levels of fibrinogen, factor VII, and factor VIII in human subjectsNutr Res.(2009 Mar)
    3. Liver Enzymes - Yang NC, Chou CW, Chen CY, Hwang KL, Yang YCCombined nattokinase with red yeast rice but not nattokinase alone has potent effects on blood lipids in human subjects with hyperlipidemia.Asia Pac J Clin Nutr.(2009)
    4. Blood Pressure - Kim JY, Gum SN, Paik JK, Lim HH, Kim KC, Ogasawara K, Inoue K, Park S, Jang Y, Lee JHEffects of nattokinase on blood pressure: a randomized, controlled trialHypertens Res.(2008 Aug)