S-adenosylmethionine

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    Last Updated: September 2, 2024

    S-adenosylmethionine (SAMe) is a metabolite in the body that helps maintain several important biological reactions. Low levels of SAMe in the body are associated with several conditions, including liver conditions, chronic kidney disease (CKD), coronary artery disease (CAD), depression, and neurodegenerative conditions like dementia and Alzheimer’s disease. Supplementation with SAMe might improve liver health and depression, but further high-quality clinical trials are needed to confirm those benefits.

    Overview

    Dosage information

    Formulations: Tablets taken orally, or liquid injected intravenously or intramuscularly.

    Range of dosages studied: 45 to 3200 milligrams per day (mg/day).

    Dosage recommendation: In some studies, the dosage range that has been found to improve depression is approximately 200 to 1,600 mg/day. In some studies, the dosage range that has been found to improve liver health in people with chronic liver conditions is approximately 800 to 1,200 mg/day

    Take with food: S-adenosylmethionine can be taken with or without food.

    Safety information:

    S-adenosylmethionine can interact with several drugs including drugs that affect serotonin, including Selective Serotonin Reuptake Inhibitors and Monoamine Oxidase Inhibitors. Due to the increased risk of mania, S-adenosylmethionine is not recommended for people with bipolar disorder.

    Frequently asked questions

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