Summary
Soy isoflavones (Genistein and Daidzein) are compounds found in a wide variety of foods, but mostly soy, that affect a wide-variety of body systems. They seem to mimic the female hormone estrogen to a degree (although slightly different).
They have been implicated in both reductions and increases of breast cancer risk, and generally are good at cardioprotection from reducing lipoprotein levels and are seen as good for bone health in the aging as well.
What are other names for Soy Isoflavones?
- Genistein
- Genistin
- Daidzein
- Daidzin
- Equol
- Dihydrogenistein
- Dihydroglycitein
- Glycitein
- Glycitin
- Soy (the food product)
- Soy Lecithin (another molecule found in soy)
Dosage information
Many anti-carcinogenic effects of genistein are seen in the range of 10-20mg/kg bodyweight a day. Epidemiologically, this dose is also associated with reduced lipoprotein levels.
In vitro studies on glucose and muscle cell metabolism showing a nutrient partitioning effect at 20-30uM correlate to a dietary intake of 200-300mg/kg bodyweight (assuming the 1uM circulating serum levels per 10mg/kg BW intake noted.[1])
Examine Database: Soy Isoflavones
Research FeedRead all studies
In this meta-analysis of randomized controlled trials in participants with chronic kidney disease, supplementing with soy protein improved some blood lipid levels, but it largely did not affect measures of kidney function.
Research Breakdown
References
Examine Database References
- Serum Albumin - Zhixiang Y, Yongxing X, Juan L, Qing Y, Yangyang L, Zhangrui Z, Yuehua GThe effects of soy protein and soy isoflavones intake on chronic kidney disease: a systematic review and meta-analysis.Int Urol Nephrol.(2024 Nov 29)