Vitamin B6 benefits, dosage, and side effects

What are other names for Vitamin B6

Note that Vitamin B6 is also known as:

Pyridoxine
Pyridoxamine
Pyridoxal
Pyridoxal Phosphate
Pyridoxal-5'-Phosphate
PLP

Examine Database: Vitamin B6

Show Conditions

Health Condition/Goal	Health Outcome	Evidence
Premenstrual Syndrome	1 Outcome	9 Studies
Hand-Foot Syndrome	1 Outcome	2 Studies
Anxiety	1 Outcome	1 Study
Primary Dysmenorrhea	1 Outcome	1 Study
Breast Pain	1 Outcome	1 Study
Metabolic Health	4 Outcomes	1 Study
Sleep Health	1 Outcome	1 Study
General Athletic Performance	2 Outcomes	1 Study

Premenstrual Syndrome

1 Outcome

9 Studies

Hand-Foot Syndrome

1 Outcome

2 Studies

Anxiety

1 Outcome

1 Study

Primary Dysmenorrhea

1 Outcome

1 Study

Breast Pain

1 Outcome

1 Study

Metabolic Health

4 Outcomes

1 Study

Sleep Health

1 Outcome

1 Study

General Athletic Performance

2 Outcomes

1 Study

Premenstrual Syndrome

9 Studies

2 Studies

1 Study

1 Study

1 Study

1 Study

1 Study

General Athletic Performance

1 Study

Research FeedRead all studies

What is vitamin B6’s relationship to peripheral neuropathy?

In this systematic review, supplementing with vitamin B6 at doses greater than 100 mg was associated with increased risk of peripheral neuropathy. Although there was evidence in this study that low vitamin B6 levels increased the risk of peripheral neuropathy, several important limitations reduce our confidence in the findings.

Which antioxidant works best for prostate cancer prevention?

Some vitamins and carotenoids may be associated with a lower risk of hearing, vision, and sleep problems

Vitamin supplementation in chronic kidney disease

The association between vitamin B6 and colorectal cancer risk

Research Breakdown

References

^Depeint F, Bruce WR, Shangari N, Mehta R, O'Brien PJMitochondrial function and toxicity: role of the B vitamin family on mitochondrial energy metabolismChem Biol Interact.(2006 Oct 27)
^Selhub JFolate, vitamin B12 and vitamin B6 and one carbon metabolismJ Nutr Health Aging.(2002)
^Chen AC, Martin AJ, Choy B, Fernández-Peñas P, Dalziell RA, McKenzie CA, Scolyer RA, Dhillon HM, Vardy JL, Kricker A, St George G, Chinniah N, Halliday GM, Damian DLA Phase 3 Randomized Trial of Nicotinamide for Skin-Cancer ChemopreventionN Engl J Med.(2015 Oct 22)
^Brasky TM, White E, Chen CLLong-Term, Supplemental, One-Carbon Metabolism-Related Vitamin B Use in Relation to Lung Cancer Risk in the Vitamins and Lifestyle (VITAL) CohortJ Clin Oncol.(2017 Oct 20)
^White E, Patterson RE, Kristal AR, Thornquist M, King I, Shattuck AL, Evans I, Satia-Abouta J, Littman AJ, Potter JDVITamins And Lifestyle cohort study: study design and characteristics of supplement usersAm J Epidemiol.(2004 Jan 1)
^Kim YIFolate and colorectal cancer: an evidence-based critical reviewMol Nutr Food Res.(2007 Mar)
^Kok DE, Dhonukshe-Rutten RA, Lute C, Heil SG, Uitterlinden AG, van der Velde N, van Meurs JB, van Schoor NM, Hooiveld GJ, de Groot LC, Kampman E, Steegenga WTThe effects of long-term daily folic acid and vitamin B12 supplementation on genome-wide DNA methylation in elderly subjectsClin Epigenetics.(2015 Nov 14)
^Corbin JM, Ruiz-Echevarría MJOne-Carbon Metabolism in Prostate Cancer: The Role of Androgen SignalingInt J Mol Sci.(2016 Jul 27)

Examine Database References

Growth Hormone - C Barletta, M Sellini, A Bartoli, C Bigi, R Buzzetti, C Giovannini[Influence of administration of pyridoxine on circadian rhythm of plasma ACTH, cortisol prolactin and somatotropin in normal subjects]Boll Soc Ital Biol Sper.(1984 Feb 28)
PMS Symptoms - Masoumi SZ, Ataollahi M, Oshvandi KEffect of Combined Use of Calcium and Vitamin B6 on Premenstrual Syndrome Symptoms: a Randomized Clinical TrialJ Caring Sci.(2016 Mar 1)
Hand-Foot Syndrome Symptoms - Corrie PG, Bulusu R, Wilson CB, Armstrong G, Bond S, Hardy R, Lao-Sirieix S, Parashar D, Ahmad A, Daniel F, Hill M, Wilson G, Blesing C, Moody AM, McAdam K, Osborne MA randomised study evaluating the use of pyridoxine to avoid capecitabine dose modificationsBr J Cancer.(2012 Aug 7)
Hand-Foot Syndrome Symptoms - C J Fabian, R Molina, M Slavik, S Dahlberg, S Giri, R StephensPyridoxine therapy for palmar-plantar erythrodysesthesia associated with continuous 5-fluorouracil infusionInvest New Drugs.(1990 Feb)
Breast Tenderness - Shobeiri F, Oshvandi K, Nazari MClinical effectiveness of vitamin E and vitamin B6 for improving pain severity in cyclic mastalgiaIran J Nurs Midwifery Res.(2015 Nov-Dec)
PMS Symptoms - Kendall KE, Schnurr PPThe effects of vitamin B6 supplementation on premenstrual symptomsObstet Gynecol.(1987 Aug)
PMS Symptoms - Kashanian M, Mazinani R, Jalalmanesh SPyridoxine (vitamin B6) therapy for premenstrual syndromeInt J Gynaecol Obstet.(2007 Jan)
PMS Symptoms - Ebrahimi E, Khayati Motlagh S, Nemati S, Tavakoli ZEffects of magnesium and vitamin b6 on the severity of premenstrual syndrome symptomsJ Caring Sci.(2012 Nov 22)
PMS Symptoms - Doll H, Brown S, Thurston A, Vessey MPyridoxine (vitamin B6) and the premenstrual syndrome: a randomized crossover trialJ R Coll Gen Pract.(1989 Sep)
PMS Symptoms - Mandana Z, Azar AComparison of the Effect of Vit E, VitB6, Calcium and Omega-3 on the Treatment of Premenstrual Syndrome: A Clinical Randomized TrialAnnu Res Rev Biol.()
PMS Symptoms - Hagen I, Nesheim BI, Tuntland TNo effect of vitamin B-6 against premenstrual tension. A controlled clinical studyActa Obstet Gynecol Scand.(1985)
PMS Symptoms - Lauritzen C, Reuter HD, Repges R, Böhnert KJ, Schmidt UTreatment of premenstrual tension syndrome with Vitex agnus castus controlled, double-blind study versus pyridoxinePhytomedicine.(1997 Sep)
PMS Symptoms - De Souza MC, Walker AF, Robinson PA, Bolland KA synergistic effect of a daily supplement for 1 month of 200 mg magnesium plus 50 mg vitamin B6 for the relief of anxiety-related premenstrual symptoms: a randomized, double-blind, crossover studyJ Womens Health Gend Based Med.(2000 Mar)
PMS Symptoms - Williams MJ, Harris RI, Dean BCControlled trial of pyridoxine in the premenstrual syndromeJ Int Med Res.(1985)
Prolactin - C Moretti, A Fabbri, L Gnessi, V Bonifacio, F Fraioli, A IsidoriPyridoxine (B6) suppresses the rise in prolactin and increases the rise in growth hormone induced by exerciseN Engl J Med.(1982 Aug 12)
Dream Salience - Ebben M, Lequerica A, Spielman AEffects of pyridoxine on dreaming: a preliminary studyPercept Mot Skills.(2002 Feb)