Age-Associated Memory Impairment and Cognitive Decline (AAMCD)

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    Louie Neri

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    Morgan Pfiffner, Graham Walker
    Last Updated: October 13, 2024

    Age-associated memory impairment and cognitive decline (AAMCD) describes the mild forgetfulness and decreased cognitive function that are considered part of “normal” aging. AAMCD differs from dementia and other more severe forms of cognitive decline in that it has no impact on daily functioning.

    7 references on this page
    12,209 participants in 16 trials and 4 meta-analyses

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    Examine Database: Age-Associated Memory Impairment and Cognitive Decline (AAMCD)

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    Examine Database References

    1. Memory - Annette Morgan, John StevensDoes Bacopa monnieri improve memory performance in older persons? Results of a randomized, placebo-controlled, double-blind trialJ Altern Complement Med.(2010 Jul)
    2. Memory - Raghav S, Singh H, Dalal PK, Srivastava JS, Asthana OPRandomized controlled trial of standardized Bacopa monniera extract in age-associated memory impairmentIndian J Psychiatry.(2006 Oct)
    3. Memory - Harshad C, et alEfficacy and Tolerability of BacoMind® on Memory Improvement in Elderly Participants - A Double Blind Placebo Controlled StudyJ Pharmacol Toxicol.()
    4. Memory - Bäurle P, Suter A, Wormstall HSafety and effectiveness of a traditional ginkgo fresh plant extract - results from a clinical trialForsch Komplementmed.(2009 Jun)
    5. Memory - Brautigam MR, Blommaert FA, Verleye G, Castermans J, Jansen Steur EN, Kleijnen JTreatment of age-related memory complaints with Ginkgo biloba extract: a randomized double blind placebo-controlled studyPhytomedicine.(1998 Dec)
    6. Cognitive Decline - Snitz BE, O'Meara ES, Carlson MC, Arnold AM, Ives DG, Rapp SR, Saxton J, Lopez OL, Dunn LO, Sink KM, DeKosky ST, Ginkgo Evaluation of Memory (GEM) Study InvestigatorsGinkgo biloba for preventing cognitive decline in older adults: a randomized trialJAMA.(2009 Dec 23)
    7. Cognitive Decline - K. Wesnes, D. Simmons, M. Rook, P. SimpsonA double-blind placebo-controlled trial of tanakan in the treatment of idiopathic cognitive impairment in the elderlyHuman Psychopharmacology: Clinical and Experimental.()
    8. Memory - Shin KY, Lee JY, Won BY, Jung HY, Chang KA, Koppula S, Suh YHBT-11 is effective for enhancing cognitive functions in the elderly humansNeurosci Lett.(2009 Nov 13)
    9. Memory - Jorissen BL, Brouns F, Van Boxtel MP, Ponds RW, Verhey FR, Jolles J, Riedel WJThe influence of soy-derived phosphatidylserine on cognition in age-associated memory impairmentNutr Neurosci.(2001)
    10. Memory - Vakhapova V, Cohen T, Richter Y, Herzog Y, Korczyn ADPhosphatidylserine containing omega-3 fatty acids may improve memory abilities in non-demented elderly with memory complaints: a double-blind placebo-controlled trialDement Geriatr Cogn Disord.(2010)
    11. Cognition - Kato-Kataoka A, Sakai M, Ebina R, Nonaka C, Asano T, Miyamori TSoybean-derived phosphatidylserine improves memory function of the elderly Japanese subjects with memory complaintsJ Clin Biochem Nutr.(2010 Nov)
    12. Memory - Krikorian R, Shidler MD, Nash TA, Kalt W, Vinqvist-Tymchuk MR, Shukitt-Hale B, Joseph JABlueberry supplementation improves memory in older adultsJ Agric Food Chem.(2010 Apr 14)
    13. Memory - Alvarez XA, Laredo M, Corzo D, Fernández-Novoa L, Mouzo R, Perea JE, Daniele D, Cacabelos RCiticoline improves memory performance in elderly subjectsMethods Find Exp Clin Pharmacol.(1997 Apr)
    14. Memory - McBean L, O'Reilly SDiet quality interventions to prevent neurocognitive decline: a systematic review and meta-analysis.Eur J Clin Nutr.(2022-Aug)
    15. Cognition - David G Loughrey, Sara Lavecchia, Sabina Brennan, Brian A Lawlor, Michelle E KellyThe Impact of the Mediterranean Diet on the Cognitive Functioning of Healthy Older Adults: A Systematic Review and Meta-AnalysisAdv Nutr.(2017 Jul 14)
    16. Cognition - Sandrine Andrieu, Sophie Guyonnet, Nicola Coley, Christelle Cantet, Marc Bonnefoy, Serge Bordes, Lawrence Bories, Marie-Noëlle Cufi, Thierry Dantoine, Jean-François Dartigues, Françoise Desclaux, Audrey Gabelle, Yannick Gasnier, Alain Pesce, Kristel Sudres, Jacques Touchon, Philippe Robert, Olivier Rouaud, Philippe Legrand, Pierre Payoux, Jean-Paul Caubere, Michael Weiner, Isabelle Carrié, Pierre-Jean Ousset, Bruno Vellas, MAPT Study GroupEffect of long-term omega 3 polyunsaturated fatty acid supplementation with or without multidomain intervention on cognitive function in elderly adults with memory complaints (MAPT): a randomised, placebo-controlled trialLancet Neurol.(2017 May)
    17. Cognitive Decline - Yurko-Mauro K, McCarthy D, Rom D, Nelson EB, Ryan AS, Blackwell A, Salem N Jr, Stedman M; MIDAS InvestigatorsBeneficial effects of docosahexaenoic acid on cognition in age-related cognitive declineAlzheimers Dement.(2010 Nov)
    18. Cognition - Markun S, Gravestock I, Jäger L, Rosemann T, Pichierri G, Burgstaller JMEffects of Vitamin B12 Supplementation on Cognitive Function, Depressive Symptoms, and Fatigue: A Systematic Review, Meta-Analysis, and Meta-Regression.Nutrients.(2021-Mar-12)
    19. Cognitive Decline - Abuzzahab FS Sr, Merwin GE, Zimmermann RL, Sherman MCA double blind investigation of piracetam (Nootropil) vs placebo in geriatric memoryPharmakopsychiatr Neuropsychopharmakol.(1977 Mar)
    20. Cognitive Decline - Waegemans T, Wilsher CR, Danniau A, Ferris SH, Kurz A, Winblad BClinical efficacy of piracetam in cognitive impairment: a meta-analysisDement Geriatr Cogn Disord.(2002)