The most common supplements studied for CKD are amino acid supplements used in conjunction with very-low-protein diets. Others include alkalizing therapy with potassium citrate salts, vitamin-d supplements, and omega-3 fatty acids supplements. Many other supplements have been investigated, including vitamin-e, antioxidant therapy, coenzyme-q10, n-acetylcysteine, bardoxolone methyl, and human recombinant superoxide dismutase, potassium, calcium fortification, nitrate, turmeric and boswellia, curcumin, vitamin-k, B vitamins, astragalus, cordyceps, and Rheum officinale.