Colorectal Cancer

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    Morgan Pfiffner, Zia Poonja
    Last Updated: October 13, 2024

    Colorectal cancer (CRC) occurs when tumors form in the lining of the colon or rectum (which together make up the large intestine). Symptoms include a change in bowel habits, fatigue, and unexplained weight loss. CRC is diagnosed after a physical exam of the colon and rectum. It can be treated in a variety of ways, including surgery, immunotherapy, and chemotherapy.

    24 references on this page
    35,068 participants in 10 trials and 6 meta-analyses

    Overview

    Examine Database: Colorectal Cancer

    Research FeedRead all studies

    Frequently asked questions

    Examine Database References

    1. Sleep Latency - Gulbeyaz Can, Erkan Topuz, Duygu Derin, Zehra Durna, Adnan AydinerEffect of kefir on the quality of life of patients being treated for colorectal cancerOncol Nurs Forum.(2009 Nov)
    2. Mucositis Symptoms - E Topuz, D Derin, G Can, E Kürklü, S Cinar, F Aykan, A Cevikbaş, R Dişçi, Z Durna, B Sakar, S Saglam, H Tanyeri, G Deniz, U Gürer, F Taş, N Guney, A AydinerEffect of oral administration of kefir on serum proinflammatory cytokines on 5-FU induced oral mucositis in patients with colorectal cancerInvest New Drugs.(2008 Dec)
    3. Weight - Ya-Feng Yang, Preety Babychen Mattamel, Tanya Joseph, Jian Huang, Qian Chen, Babatunde O Akinwunmi, Casper J P Zhang, Wai-Kit MingEfficacy of Low-Carbohydrate Ketogenic Diet as an Adjuvant Cancer Therapy: A Systematic Review and Meta-Analysis of Randomized Controlled TrialsNutrients.(2021 Apr 21)
    4. Weight - Marzieh Taftian, Sara Beigrezaei, Vahid Arabi, Amin Salehi-AbargoueiThe Effect of Ketogenic Diet on Weight Loss in Adult Patients with Cancer: A Systematic Review and Meta-Analysis of Controlled Clinical TrialsNutr Cancer.(2022 Feb 7)
    5. Weight - Amanollahi A, Khazdouz M, Malekahmadi M, Klement RJ, Lee D, Khodabakhshi AEffect of Ketogenic Diets on Cardio-Metabolic Outcomes in Cancer Patients: A Systematic Review and Meta-Analysis of Controlled Clinical Trials.Nutr Cancer.(2023)
    6. Bloating - Yang R, Liu W, Cai S, Feng X, Chen Y, Cheng X, Ma J, Ma W, Tian Z, Yang WEvaluation of the efficacy of probiotics in the chemoradiotherapy of colorectal cancer: a meta-analysis of Randomized Controlled Trials.BMC Gastroenterol.(2025 Apr 29)
    7. Subjective Well-Being - Norman K, Stübler D, Baier P, Schütz T, Ocran K, Holm E, Lochs H, Pirlich MEffects of creatine supplementation on nutritional status, muscle function and quality of life in patients with colorectal cancer--a double blind randomised controlled trialClin Nutr.(2006 Aug)
    8. Colorectal Cancer Risk - Zick SM, Turgeon DK, Vareed SK, Ruffin MT, Litzinger AJ, Wright BD, Alrawi S, Normolle DP, Djuric Z, Brenner DEPhase II study of the effects of ginger root extract on eicosanoids in colon mucosa in people at normal risk for colorectal cancerCancer Prev Res (Phila).(2011 Nov)
    9. Colorectal Cancer Risk - Oka S, Tanaka S, Yoshida S, Hiyama T, Ueno Y, Ito M, Kitadai Y, Yoshihara M, Chayama KA water-soluble extract from culture medium of Ganoderma lucidum mycelia suppresses the development of colorectal adenomasHiroshima J Med Sci.(2010 Mar)
    10. Colorectal Cancer Risk - Gorham ED, Garland CF, Garland FC, Grant WB, Mohr SB, Lipkin M, Newmark HL, Giovannucci E, Wei M, Holick MFOptimal vitamin D status for colorectal cancer prevention: a quantitative meta analysisAm J Prev Med.(2007 Mar)
    11. Colorectal Cancer Risk - Robert E Carroll, Richard V Benya, Danielle Kim Turgeon, Shaiju Vareed, Malloree Neuman, Luz Rodriguez, Madhuri Kakarala, Philip M Carpenter, Christine McLaren, Frank L Meyskens Jr, Dean E BrennerPhase IIa clinical trial of curcumin for the prevention of colorectal neoplasiaCancer Prev Res (Phila).(2011 Mar)
    12. Colorectal Cancer Risk - He ZY, Shi CB, Wen H, Li FL, Wang BL, Wang JUpregulation of p53 expression in patients with colorectal cancer by administration of curcuminCancer Invest.(2011 Mar)
    13. Colorectal Cancer Risk - Moazzen S, Dolatkhah R, Tabrizi JS, Shaarbafi J, Alizadeh BZ, de Bock GH, Dastgiri SFolic acid intake and folate status and colorectal cancer risk: A systematic review and meta-analysis.Clin Nutr.(2018-Dec)
    14. Inflammation - Rotovnik Kozjek N, Kompan L, Soeters P, Oblak I, Mlakar Mastnak D, Možina B, Zadnik V, Anderluh F, Velenik VOral glutamine supplementation during preoperative radiochemotherapy in patients with rectal cancer: a randomised double blinded, placebo controlled pilot studyClin Nutr.(2011 Oct)
    15. IGF Binding Protein - Vrieling A, Rookus MA, Kampman E, Bonfrer JM, Korse CM, van Doorn J, Lampe JW, Cats A, Witteman BJ, van Leeuwen FE, van't Veer LJ, Voskuil DWIsolated isoflavones do not affect the circulating insulin-like growth factor system in men at increased colorectal cancer riskJ Nutr.(2007 Feb)
    16. IGF Binding Protein - Vrieling A, Rookus MA, Kampman E, Bonfrer JM, Bosma A, Cats A, van Doorn J, Korse CM, Witteman BJ, van Leeuwen FE, van't Veer LJ, Voskuil DWNo effect of red clover-derived isoflavone intervention on the insulin-like growth factor system in women at increased risk of colorectal cancerCancer Epidemiol Biomarkers Prev.(2008 Oct)
    Colorectal Cancer: Symptoms, causes, treatments, and your questions answered.