Major Depressive Disorder (MDD)

    Written by:
    Brady Holmer
    Last Updated: October 13, 2024

    MDD, otherwise known as clinical depression or major depression, is a more severe form of depression that may involve feelings of sadness, angry outbursts, a loss of interest in everyday activities, fatigue, feelings of worthlessness, difficulty thinking, and thoughts of suicide.

    2,354 participants in 9 trials and 3 meta-analyses

    Examine Database: Major Depressive Disorder (MDD)

    Research FeedRead all studies

    Examine Database References

    1. Depression Symptoms - Sanmukhani J, Satodia V, Trivedi J, Patel T, Tiwari D, Panchal B, Goel A, Tripathi CBEfficacy and safety of curcumin in major depressive disorder: a randomized controlled trialPhytother Res.(2014 Apr)
    2. Depression Symptoms - Panahi Y, Badeli R, Karami GR, Sahebkar AInvestigation of the efficacy of adjunctive therapy with bioavailability-boosted curcuminoids in major depressive disorderPhytother Res.(2015 Jan)
    3. Depression Symptoms - Sepehrmanesh Z, Kolahdooz F, Abedi F, Mazroii N, Assarian A, Asemi Z, Esmaillzadeh AVitamin D Supplementation Affects the Beck Depression Inventory, Insulin Resistance, and Biomarkers of Oxidative Stress in Patients with Major Depressive Disorder: A Randomized, Controlled Clinical TrialJ Nutr.(2016 Feb)
    4. Depression Symptoms - Laura Micheli, Silvia Spitoni, Lorenzo Di Cesare Mannelli, Anna Rita Bilia, Carla Ghelardini, Stefano PallantiBacopa monnieri as augmentation therapy in the treatment of anhedonia, preclinical and clinical evaluationPhytother Res.(2020 Sep)
    5. Depression Symptoms - Davidson JR, Abraham K, Connor KM, McLeod MNEffectiveness of chromium in atypical depression: a placebo-controlled trialBiol Psychiatry.(2003 Feb 1)
    6. Depression Symptoms - Hausenblas HA, Saha D, Dubyak PJ, Anton SDSaffron (Crocus sativus L.) and major depressive disorder: a meta-analysis of randomized clinical trialsJ Integr Med.(2013 Nov)
    7. Blood glucose - Mansoori P, et alA Randomized, Double-blind, Placebo - controlled Study of Safety of the Adjunctive Saffron on Sexual Dysfunction Induced by a Selective Serotonin Reuptake InhibitorJ Med Plant .()
    8. Depression Symptoms - Jahangard L, Sadeghi A, Ahmadpanah M, Holsboer-Trachsler E, Sadeghi Bahmani D, Haghighi M, Brand SInfluence of adjuvant omega-3-polyunsaturated fatty acids on depression, sleep, and emotion regulation among outpatients with major depressive disorders - Results from a double-blind, randomized and placebo-controlled clinical trialJ Psychiatr Res.(2018 Dec)
    9. Depression Symptoms - Baron ShopsinThe clinical antidepressant effect of exogenous agmatine is not reversed by parachlorophenylalanine: a pilot studyActa Neuropsychiatrica.()
    10. Depression Symptoms - N Gecele, G Francesetti, A MeluzziAcetyl-L-Carnitine in Aged Subjects with Major Depression: Clinical Efficacy and Effects on the Circadian Rhythm of CortisolDement Geriatr Cogn Disord.()
    11. Depression Symptoms - Firoozeei TS, Feizi A, Rezaeizadeh H, Zargaran A, Roohafza HR, Karimi MThe antidepressant effects of lavender (Lavandula angustifolia Mill.): A systematic review and meta-analysis of randomized controlled clinical trials.Complement Ther Med.(2021-Jun)
    12. Depression Symptoms - Maruf AA, Poweleit EA, Brown LC, Strawn JR, Bousman CASystematic Review and Meta-Analysis of L-Methylfolate Augmentation in Depressive Disorders.Pharmacopsychiatry.(2022-May)