RCTs have assessed a number of supplements’ effects on established Alzheimer’s disease. This includes omega-3s, B vitamins (usually folic acid, vitamin B6, and vitamin B12), vitamin D, vitamin E, ginkgo biloba, L-alpha glycerylphosphorylcholine (alpha-GPC), Lion's mane mushroom, ginseng, saffron, and sodium oligomannate. For the most part, these supplements have only conflicting or limited evidence in favor of their use.
Have any supplements been studied for Alzheimer’s disease?
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•Last Updated: May 16, 2025
Several supplements — including omega-3s, B vitamins, vitamin D, vitamin E, ginkgo biloba, alpha-GPC, lion's mane mushroom, ginseng, saffron, and sodium oligomannate — have been studied for their effects on established Alzheimer's disease. However, the evidence supporting their use is mostly conflicting or limited.