Examine Database: Endothelial Function
| Intervention | Grade | Effect | Detail |
|---|---|---|---|
| Grape Seed Extract | D | ||
| Citrulline | B | ||
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Research FeedRead all studies
L-citrulline for healthier blood vessels
In this meta-analysis of 8 randomized controlled trials in 176 middle-aged and older adults, supplementation with L-citrulline improved endothelial function but not arterial stiffness, compared to a placebo, whereas watermelon juice showed no effects.
Coffee's chlorogenic acid may improve blood vessel function
Examine Database References
- Citrulline - Luo P, Li Z, Liu K, Gao WEffects of L-citrulline supplementation and watermelon intake on arterial stiffness and endothelial function in middle-aged and older adults: a systematic review and meta-analysis of randomized controlled trials.Front Nutr.(2025)
- Grape Seed Extract - Ashoori M, Soltani S, Kolahdouz-Mohammadi R, Moghtaderi F, Clayton Z, Abdollahi SThe effect of whole grape products on blood pressure and vascular function: A systematic review and meta-analysis of randomized controlled trials.Nutr Metab Cardiovasc Dis.(2023-May-05)
- Grape Seed Extract - Foshati S, Nouripour F, Sadeghi E, Amani RThe effect of grape (Vitis vinifera) seed extract supplementation on flow-mediated dilation, blood pressure, and heart rate: A systematic review and meta-analysis of controlled trials with duration- and dose-response analysis.Pharmacol Res.(2022 Jan)