Formulation

Umckaloabo is most studied as an oral preparation (liquid drops, tablets, and syrups) of Pelargonium sidoides root extract. Liquid and tablet forms are typically cited in the current clinical evidence with dosage, frequency, and timing adjusted according to age and indication for use.^{[1][2][3][4][5][6][7][8][9]}

EPs 7630 is a commonly studied standardized extract, which contains an ethanol (11% w/w) extract at a ratio of 1:8–10.^[2][7][8][9]

Range of dosages studied

Dosages vary across studies and populations and depend on age and formulation. For adults, total daily doses ranged from 90 mg to 7.2 grams (7,200 mg), and children’s dosages tended to range from 30 mg to 3.6 grams (3,600 mg) per day. The most typical regimen for drops, regardless of age, was 10 to 30 drops per dose, three times per day (equating to about 120–240 mg per day). Tablets were more often dosed between 30 mg and 90 mg per day. Duration of treatment and follow-up after the study lasted anywhere from 5 days to 21 days, with 7 to 10 days being the most frequent duration.^{[1][2][3][4][5][6][7][8][9]}

Other Considerations

The most consistently used formulation in research is the standardized extract EPs 7630.^[2][7][8][9]