Irisin

•Last Updated: October 13, 2024

Irisin is a myokine (i.e., a cytokine secreted by muscle cells in response to muscular contraction) derived from the FNDC5 protein. There is great interest in irisin for its potential roles in browning white fat cells, insulin sensitivity, neurogenesis, and bone metabolism.

16 participants in 1 trial

Examine Evidence Grades

Last Updated:October 13, 2024

16 participants in 1 trial

Examine Evidence Grades

Examine Database: Irisin

C

Participants: 16

Small Increase

Intervention	Grade	Effect	Detail
Ursolic Acid	C

Research FeedRead all studies

Curcumin and/or HIIT may improve blood lipids in women with obesity

In this 8-week randomized controlled trial in 40 sedentary women (ages 30–35) with obesity, supplementation with curcumin, high-intensity interval training (HIIT), and the combination of the two increased serum irisin and improved blood lipid profiles.

Soy milk can enhance resistance training adaptations in older men

Examine Database References

Ursolic Acid - Bang HS, Seo DY, Chung YM, Oh KM, Park JJ, Arturo F, Jeong SH, Kim N, Han JUrsolic Acid-induced elevation of serum irisin augments muscle strength during resistance training in menKorean J Physiol Pharmacol.(2014 Oct)