Liver Fat

    Last Updated: October 13, 2024

    Liver fat refers to the triglycerides that can be stored in the liver, of which their excess accumulations results in fatty liver (alcohol or non-alcoholic) and possibly later cirrhosis. Some supplements may be able to reduce liver fat stores.

    6,283 participants in 27 trials

    Examine Database: Liver Fat

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    Examine Database References

    1. Spirulina - Ferreira-Hermosillo A, Torres-Duran PV, Juarez-Oropeza MAHepatoprotective effects of Spirulina maxima in patients with non-alcoholic fatty liver disease: a case seriesJ Med Case Rep.(2010 Apr 7)
    2. Vitamin E - T Hasegawa, M Yoneda, K Nakamura, I Makino, A TeranoPlasma transforming growth factor-beta1 level and efficacy of alpha-tocopherol in patients with non-alcoholic steatohepatitis: a pilot studyAliment Pharmacol Ther.(2001 Oct)
    3. Brown Seaweed Extract - Abidov M, Ramazanov Z, Seifulla R, Grachev SThe effects of Xanthigen in the weight management of obese premenopausal women with non-alcoholic fatty liver disease and normal liver fatDiabetes Obes Metab.(2010 Jan)
    4. Whey Protein - Chitapanarux T, Tienboon P, Pojchamarnwiputh S, Leelarungrayub DOpen-labeled pilot study of cysteine-rich whey protein isolate supplementation for nonalcoholic steatohepatitis patientsJ Gastroenterol Hepatol.(2009 Jun)
    5. Betaine - Sandeep Mukherjee, Tamara Bernard, Kusum Kharbanda, Anthony J. Barak, Michael F. Sorrell, Dean J. TumaImpact of Betaine on Hepatic Fibrosis and Homocysteine in Nonalcoholic Steatohepatitis - A Prospective, Cohort StudyThe Open Translational Medicine Journal.()
    6. Betaine - Abdelmalek MF, Sanderson SO, Angulo P, Soldevila-Pico C, Liu C, Peter J, Keach J, Cave M, Chen T, McClain CJ, Lindor KDBetaine for nonalcoholic fatty liver disease: results of a randomized placebo-controlled trialHepatology.(2009 Dec)
    7. Citrulline - Zahra Darabi, Mina Darand, Zahra Yari, Mehdi Hedayati, Amirhosein Faghihi, Shahram Agah, Azita HekmatdoostInflammatory markers response to citrulline supplementation in patients with non-alcoholic fatty liver disease: a randomized, double blind, placebo-controlled, clinical trialBMC Res Notes.(2019 Feb 15)
    8. Curcumin - Saeede Saadati, Behzad Hatami, Zahra Yari, Mohammad Amin Shahrbaf, Sareh Eghtesad, Asieh Mansour, Hossein Poustchi, Mehdi Hedayati, Morteza Aghajanpoor-Pasha, Amir Sadeghi, Azita HekmatdoostThe effects of curcumin supplementation on liver enzymes, lipid profile, glucose homeostasis, and hepatic steatosis and fibrosis in patients with non-alcoholic fatty liver diseaseEur J Clin Nutr.(2019 Mar)
    9. Ketogenic Diet - Kirk E, Reeds DN, Finck BN, Mayurranjan SM, Patterson BW, Klein SDietary fat and carbohydrates differentially alter insulin sensitivity during caloric restrictionGastroenterology.(2009 May)
    10. Ketogenic Diet - Athinarayanan SJ, Adams RN, Hallberg SJ, McKenzie AL, Bhanpuri NH, Campbell WW, Volek JS, Phinney SD, McCarter JPLong-Term Effects of a Novel Continuous Remote Care Intervention Including Nutritional Ketosis for the Management of Type 2 Diabetes: A 2-Year Non-randomized Clinical TrialFront Endocrinol (Lausanne).(2019 Jun 5)
    11. Vitamin E - Sumida Y, Naito Y, Tanaka S, Sakai K, Inada Y, Taketani H, Kanemasa K, Yasui K, Itoh Y, Okanoue T, Yoshikawa TLong-term (>=2 yr) efficacy of vitamin E for non-alcoholic steatohepatitisHepatogastroenterology.(2013 Sep)
    12. Whey Protein - Bortolotti M, Maiolo E, Corazza M, Van Dijke E, Schneiter P, Boss A, Carrel G, Giusti V, Lê KA, Quo Chong DG, Buehler T, Kreis R, Boesch C, Tappy LEffects of a whey protein supplementation on intrahepatocellular lipids in obese female patientsClin Nutr.(2011 Aug)
    13. Curcumin - Panahi Y, Khalili N, Sahebi E, Namazi S, Simental-Mendía LE, Majeed M, Sahebkar AEffects of Curcuminoids Plus Piperine on Glycemic, Hepatic and Inflammatory Biomarkers in Patients with Type 2 Diabetes Mellitus: A Randomized Double-Blind Placebo-Controlled TrialDrug Res (Stuttg).(2018 Jul)
    14. Vitamin E - Sanyal AJ, Chalasani N, Kowdley KV, McCullough A, Diehl AM, Bass NM, Neuschwander-Tetri BA, Lavine JE, Tonascia J, Unalp A, Van Natta M, Clark J, Brunt EM, Kleiner DE, Hoofnagle JH, Robuck PR, NASH CRNPioglitazone, vitamin E, or placebo for nonalcoholic steatohepatitisN Engl J Med.(2010 May 6)
    15. L-Carnitine - Mohamad Hosein Somi, Ebrahim Fatahi, Jafar Panahi, Mohamad Reza Havasian, Arezo JudakiData from a randomized and controlled trial of LCarnitine prescription for the treatment for Non- Alcoholic Fatty Liver DiseaseBioinformation.(2014 Sep 30)
    16. Curcumin - Cicero AFG, Sahebkar A, Fogacci F, Bove M, Giovannini M, Borghi CEffects of phytosomal curcumin on anthropometric parameters, insulin resistance, cortisolemia and non-alcoholic fatty liver disease indices: a double-blind, placebo-controlled clinical trialEur J Nutr.(2019 Feb 22)
    17. Ketogenic Diet - Parker N Hyde, Teryn N Sapper, Christopher D Crabtree, Richard A LaFountain, Madison L Bowling, Alex Buga, Brandon Fell, Fionn T McSwiney, Ryan M Dickerson, Vincent J Miller, Debbie Scandling, Orlando P Simonetti, Stephen D Phinney, William J Kraemer, Sarah A King, Ronald M Krauss, Jeff S VolekDietary carbohydrate restriction improves metabolic syndrome independent of weight lossJCI Insight.(2019 Jun 20)
    18. Fish Oil - Nobili V, Bedogni G, Alisi A, Pietrobattista A, Risé P, Galli C, Agostoni CDocosahexaenoic acid supplementation decreases liver fat content in children with non-alcoholic fatty liver disease: double-blind randomised controlled clinical trialArch Dis Child.(2011 Apr)
    19. Betaine - Abdelmalek MF, Angulo P, Jorgensen RA, Sylvestre PB, Lindor KDBetaine, a promising new agent for patients with nonalcoholic steatohepatitis: results of a pilot studyAm J Gastroenterol.(2001 Sep)
    20. Curcumin - M H Ngu, M N Norhayati, Z Rosnani, M M ZulkifliCurcumin as adjuvant treatment in patients with non-alcoholic fatty liver (NAFLD) disease: A systematic review and meta-analysisComplement Ther Med.(2022 Sep)
    21. Mediterranean Diet - Takumi Kawaguchi, Michael Charlton, Atsushi Kawaguchi, Sakura Yamamura, Dan Nakano, Tsubasa Tsutsumi, Maryam Zafer, Takuji TorimuraEffects of Mediterranean Diet in Patients with Nonalcoholic Fatty Liver Disease: A Systematic Review, Meta-Analysis, and Meta-Regression Analysis of Randomized Controlled TrialsSemin Liver Dis.(2021 Aug)
    22. Mediterranean Diet - Akhlaghi M, Ghasemi-Nasab M, Riasatian MMediterranean diet for patients with non-alcoholic fatty liver disease, a systematic review and meta-analysis of observational and clinical investigations.J Diabetes Metab Disord.(2020-Jun)
    23. Mediterranean Diet - Veera Houttu, Susanne Csader, Max Nieuwdorp, Adriaan G Holleboom, Ursula SchwabDietary Interventions in Patients With Non-alcoholic Fatty Liver Disease: A Systematic Review and Meta-AnalysisFront Nutr.(2021 Jul 22)
    24. Mediterranean Diet - Haigh L, Kirk C, El Gendy K, Gallacher J, Errington L, Mathers JC, Anstee QMThe effectiveness and acceptability of Mediterranean diet and calorie restriction in non-alcoholic fatty liver disease (NAFLD): A systematic review and meta-analysis.Clin Nutr.(2022-Sep)
    25. Black seed - Gang Tang, Linyu Zhang, Jie Tao, Zhengqiang WeiEffect of Nigella sativa in the treatment of nonalcoholic fatty liver disease: A systematic review and meta-analysis of randomized controlled trialsPhytother Res.(2021 Mar 16)
    26. Vitamin E - Chee NM, Sinnanaidu RP, Chan WKVitamin E improves serum markers and histology in adults with metabolic dysfunction-associated steatotic liver disease: Systematic review and meta-analysis.J Gastroenterol Hepatol.(2024 Aug 16)
    27. Synbiotics - Musazadeh V, Assadian K, Rajabi F, Faghfouri AH, Soleymani Y, Kavyani Z, Najafiyan BThe effect of synbiotics on liver enzymes, obesity indices, blood pressure, lipid profile, and inflammation in patients with non-alcoholic fatty liver: A systematic review and meta-analysis of randomized controlled trials.Pharmacol Res.(2024 Oct)