Examine Database: Migraine Severity
| Intervention | Grade | Effect | Detail |
|---|---|---|---|
| Vitamin D | D | ||
| Magnesium | B | ||
| Coenzyme Q10 | D | ||
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| Alpha-Lipoic Acid | |||
| Probiotics | |||
| Feverfew | |||
| Riboflavin (Vitamin B2) | |||
| L-Carnitine | |||
| Vegan Diet | |||
| Selenium | |||
| Melatonin | |||
| Lavender | |||
| Chaste tree | |||
Research FeedRead all studies
Palmitoylethanolamide and melatonin may make migraines more manageable
In this 3-month randomized controlled trial in 60 participants with episodic migraine, supplementation with palmitoylethanolamide (PEA) and low-dose melatonin reduced the frequency, intensity, and duration of migraines.
Can fatty acids reduce migraine severity?
Dietary approaches for migraines
Can probiotics and vitamin D reduce migraine severity?
Dietary supplements for migraine relief
Examine Database References
- L-Carnitine - Knut Hagen, Eiliv Brenner, Mattias Linde, Gøril Bruvik Gravdahl, Erling Andreas Tronvik, Morten Engstrøm, Ursula Sonnewald, Grethe Helde, Lars Jacob Stovner, Trond SandAcetyl-l-carnitine versus placebo for migraine prophylaxis: A randomized, triple-blind, crossover studyCephalalgia.(2015 Oct)
- Chaste tree - Zamani M, Neghab N, Torabian STherapeutic effect of Vitex agnus castus in patients with premenstrual syndromeActa Med Iran.(2012)
- Vegan Diet - Anne E Bunner, Ulka Agarwal, Joseph F Gonzales, Francesca Valente, Neal D BarnardNutrition intervention for migraine: a randomized crossover trialJ Headache Pain.(2014 Oct 23)
- L-Carnitine - Ali Tarighat Esfanjani, Reza Mahdavi, Mehrangiz Ebrahimi Mameghani, Mahnaz Talebi, Zeinab Nikniaz, Abdolrasool SafaiyanThe effects of magnesium, L-carnitine, and concurrent magnesium-L-carnitine supplementation in migraine prophylaxisBiol Trace Elem Res.(2012 Dec)
- Magnesium - Kandil M, Jaber S, Desai D, Nuñez Cruz S, Lomotan N, Ahmad U, Cirone M, Burkins J, McDowell MMAGraine: Magnesium compared to conventional therapy for treatment of migraines.Am J Emerg Med.(2021-Jan)
- Selenium - .(2024-05-01)
- Melatonin - Gonçalves AL, Martini Ferreira A, Ribeiro RT, Zukerman E, Cipolla-Neto J, Peres MFRandomised clinical trial comparing melatonin 3 mg, amitriptyline 25 mg and placebo for migraine prevention.J Neurol Neurosurg Psychiatry.(2016 Oct)
- Lavender - Sasannejad P, Saeedi M, Shoeibi A, Gorji A, Abbasi M, Foroughipour MLavender essential oil in the treatment of migraine headache: a placebo-controlled clinical trialEur Neurol.(2012)
- Riboflavin (Vitamin B2) - Bruijn J, Duivenvoorden H, Passchier J, Locher H, Dijkstra N, Arts WFMedium-dose riboflavin as a prophylactic agent in children with migraine: a preliminary placebo-controlled, randomised, double-blind, cross-over trialCephalalgia.(2010 Mar 26)
- Riboflavin (Vitamin B2) - MacLennan SC, Wade FM, Forrest KM, Ratanayake PD, Fagan E, Antony JHigh-dose riboflavin for migraine prophylaxis in children: a double-blind, randomized, placebo-controlled trialJ Child Neurol.(2008 Nov)
- Coenzyme Q10 - Dahri M, Tarighat-Esfanjani A, Asghari-Jafarabadi M, Hashemilar MOral coenzyme Q10 supplementation in patients with migraine: Effects on clinical features and inflammatory markersNutr Neurosci.(2018 Jan 3)
- Coenzyme Q10 - Dahri M, Hashemilar M, Asghari-Jafarabadi M, Tarighat-Esfanjani AEfficacy of coenzyme Q10 for the prevention of migraine in women: A randomized, double-blind, placebo-controlled studyEur J Integr Med.(2017 Oct 12)
- Coenzyme Q10 - Sándor PS, Di Clemente L, Coppola G, Saenger U, Fumal A, Magis D, Seidel L, Agosti RM, Schoenen JEfficacy of coenzyme Q10 in migraine prophylaxis: a randomized controlled trialNeurology.(2005 Feb 22)
- Coenzyme Q10 - Shoeibi A, Olfati N, Soltani Sabi M, Salehi M, Mali S, Akbari Oryani MEffectiveness of coenzyme Q10 in prophylactic treatment of migraine headache: an open-label, add-on, controlled trialActa Neurol Belg.(2016 Sep 26)
- Coenzyme Q10 - Slater SK, Nelson TD, Kabbouche MA, LeCates SL, Horn P, Segers A, Manning P, Powers SW, Hershey ADA randomized, double-blinded, placebo-controlled, crossover, add-on study of CoEnzyme Q10 in the prevention of pediatric and adolescent migraineCephalalgia.(2011 Jun)
- Feverfew - Pfaffenrath V, Diener HC, Fischer M, Friede M, Henneicke-von Zepelin HH; InvestigatorsThe efficacy and safety of Tanacetum parthenium (feverfew) in migraine prophylaxis--a double-blind, multicentre, randomized placebo-controlled dose-response studyCephalalgia.(2002 Sep)
- Feverfew - Murphy JJ, Heptinstall S, Mitchell JRRandomised double-blind placebo-controlled trial of feverfew in migraine preventionLancet.(1988 Jul 23)
- Magnesium - Köseoglu E, Talaslioglu A, Gönül AS, Kula MThe effects of magnesium prophylaxis in migraine without auraMagnes Res.(2008 Jun)
- Coenzyme Q10 - Parohan M, Sarraf P, Javanbakht MH, Foroushani AR, Ranji-Burachaloo S, Djalali MThe synergistic effects of nano-curcumin and coenzyme Q10 supplementation in migraine prophylaxis: a randomized, placebo-controlled, double-blind trialNutr Neurosci.(2019 Jun 26)
- Magnesium - Talandashti MK, Shahinfar H, Delgarm P, Jazayeri SEffects of selected dietary supplements on migraine prophylaxis: A systematic review and dose-response meta-analysis of randomized controlled trials.Neurol Sci.(2024 Oct 15)
- Magnesium - Khani S, Hejazi SA, Yaghoubi M, Sharifipour EComparative study of magnesium, sodium valproate, and concurrent magnesium-sodium valproate therapy in the prevention of migraine headaches: a randomized controlled double-blind trial.J Headache Pain.(2021-Apr-07)