Alpha-lipoic acid (ALA) is a mitochondrial compound involved in energy metabolism. It is commonly taken with L-Carnitine supplements, as they are related in mechanisms. ALA provides a short but potent reduction of oxidation by increasing antioxidant enzymes, and may decrease blood glucose acutely.
Alpha-Lipoic Acid is most often used for
ALA may have a protective effect on neurons, as it was found that people with multiple sclerosis (MS) supplementing with ALA for 2 years experienced a smaller decrease in brain volume than expected. Furthermore, ALA may reduce disability scores and improve walking performance in people with MS.
ALA has inconsistent benefits for the treatment of complications from type 2 diabetes such as pain from diabetic neuropathy.
ALA has a small but consistent body of research supporting its ability to improve semen parameters like sperm concentration and sperm motility. It also appears to be beneficial for female fertility processes like oocyte maturation, fertilization, and embryo development in the context of polycystic ovary syndrome (PCOS).
ALA is involved in cellular respiration in the mitochondria by serving as a cofactor of the pyruvate dehydrogenase complex, a key enzyme involved in energy production.
ALA may benefit neurological health by increasing Nf-e2-related factor 2 (Nrf2), which increases phase II detoxification and antioxidant genes, potentially reducing oxidative damage. ALA’s role in decreasing oxidative stress and inflammation may benefit vascular health as well. ALA also mildly increases flow-mediated dilation (a measure of vascular function), possibly by increasing endothelium-derived nitric oxide.
- thioctic acid
- 1 2-dithiolane-3-pentanoic acid
- Alpha-Linolenic Acid (omega-3 fatty acid)
Standard dosages of Alpha-Lipoic Acid (ALA) tend to be in the range of 300-600mg, with little differentiation based on whether the racemic mixture of ALA (S- and R- isomers) or Na-R-ALA results in higher blood levels.
ALA appears to be absorbed via transporter-related means, and despite being inherently fat-soluble it does not require dietary fatty acids to be absorbed from the gut. ALA supplementation can be taken in a fasted state.
Unlock the full potential of Examine