Sperm Quality

    Last Updated: October 13, 2024

    Sperm quality refers to the structural capacity of sperm cells and their ability to fertilize (and does not necessarily reflect sperm count nor motility). Supplements that improve sperm quality are thought to be pro-fertility agents.

    3,232 participants in 33 trials

    Examine Database: Sperm Quality

    Research FeedRead all studies

    Examine Database References

    1. L-Carnitine - Giorgio Cavallini, Anna Pia Ferraretti, Luca Gianaroli, Giulio Biagiotti, Giovanni VitaliCinnoxicam and L-carnitine/acetyl-L-carnitine treatment for idiopathic and varicocele-associated oligoasthenospermiaJ Androl.(Sep-Oct 2004)
    2. D-Aspartic Acid - mma D’Aniello, Salvatore Ronsini, Tiziana Notari, Natascia Grieco, Vincenzo Infante, Nicola D’Angel, Fara Mascia, Maria Maddalena Di Fiore, George Fisher, Antimo D’AnielloD-Aspartate, a Key Element for the Improvement of Sperm QualityMedicine and Healthcare.()
    3. Ashwagandha - Ambiye VR, Langade D, Dongre S, Aptikar P, Kulkarni M, Dongre AClinical Evaluation of the Spermatogenic Activity of the Root Extract of Ashwagandha (Withania somnifera) in Oligospermic Males: A Pilot StudyEvid Based Complement Alternat Med.(2013)
    4. Ashwagandha - Nasimi Doost Azgomi R, Nazemiyeh H, Sadeghi Bazargani H, Fazljou SMB, Nejatbakhsh F, Moini Jazani A, Ahmadi AsrBadr Y, Zomorrodi AComparative evaluation of the effects of Withania somnifera with pentoxifylline on the sperm parameters in idiopathic male infertility: A triple-blind randomised clinical trialAndrologia.(2018 Sep)
    5. L-Carnitine - Gholamreza Pourmand, Mansooreh Movahedin, Sanaz Dehghani, Abdolrassul Mehrsai, Ayat Ahmadi, Maryam Pourhosein, Marzieh Hoseini, Marzieh Ziloochi, Fariba Heidari, Laleh Beladi, Mohammad NooriDoes L-carnitine therapy add any extra benefit to standard inguinal varicocelectomy in terms of deoxyribonucleic acid damage or sperm quality factor indices: a randomized studyUrology.(2014 Oct)
    6. Tongkat Ali - Ismail SB, Wan Mohammad WM, George A, Nik Hussain NH, Musthapa Kamal ZM, Liske ERandomized Clinical Trial on the Use of PHYSTA Freeze-Dried Water Extract of Eurycoma longifolia for the Improvement of Quality of Life and Sexual Well-Being in MenEvid Based Complement Alternat Med.(2012)
    7. Maca - Melnikovova I, Fait T, Kolarova M, Fernandez EC, Milella LEffect of Lepidium meyenii Walp. on Semen Parameters and Serum Hormone Levels in Healthy Adult Men: A Double-Blind, Randomized, Placebo-Controlled Pilot StudyEvid Based Complement Alternat Med.(2015)
    8. Tribulus Terrestris - Roaiah MF, Elkhayat YI, Saleh SF, Abd El Salam MAProspective Analysis on the Effect of Botanical Medicine (Tribulus terrestris) on Serum Testosterone Level and Semen Parameters in Males with Unexplained InfertilityJ Diet Suppl.(2016 Jun 23)
    9. Ashwagandha - Ahmad MK, Mahdi AA, Shukla KK, Islam N, Rajender S, Madhukar D, Shankhwar SN, Ahmad SWithania somnifera improves semen quality by regulating reproductive hormone levels and oxidative stress in seminal plasma of infertile malesFertil Steril.(2010 Aug)
    10. L-Carnitine - Lenzi A, Lombardo F, Sgrò P, Salacone P, Caponecchia L, Dondero F, Gandini LUse of carnitine therapy in selected cases of male factor infertility: a double-blind crossover trialFertil Steril.(2003 Feb)
    11. Tribulus Terrestris - Sellandi TM, Thakar AB, Baghel MSClinical study of Tribulus terrestris Linn. in Oligozoospermia: A double blind studyAyu.(2012 Jul)
    12. Ginger - Waleed Abid Al-Kadir Mares, Wisam S. NajamThe effect of Ginger on semen parameters and serum FSH, LH & testosterone of infertile menTikrit Medical Journal.()
    13. Spirulina - Roya Modarresi, Alireza Aminsharifi, Farzaneh ForoughiniaImpact of Spirulina Supplementation on Semen Parameters in Patients with Idiopathic Male Infertility: A Pilot Randomized TrialUrol J.(2019 Feb 21)
    14. Coenzyme Q10 - Safarinejad MREfficacy of coenzyme Q10 on semen parameters, sperm function and reproductive hormones in infertile menJ Urol.(2009 Jul)
    15. Ashwagandha - Gupta A, Mahdi AA, Shukla KK, Ahmad MK, Bansal N, Sankhwar P, Sankhwar SNEfficacy of Withania somnifera on seminal plasma metabolites of infertile males: a proton NMR study at 800 MHzJ Ethnopharmacol.(2013 Aug 26)
    16. Astaxanthin - Comhaire FH, El Garem Y, Mahmoud A, Eertmans F, Schoonjans FCombined conventional/antioxidant "Astaxanthin" treatment for male infertility: a double blind, randomized trialAsian J Androl.(2005 Sep)
    17. L-Carnitine - Balercia G, Regoli F, Armeni T, Koverech A, Mantero F, Boscaro MPlacebo-controlled double-blind randomized trial on the use of L-carnitine, L-acetylcarnitine, or combined L-carnitine and L-acetylcarnitine in men with idiopathic asthenozoospermiaFertil Steril.(2005 Sep)
    18. Saffron - Elham Karimi-Nazari, Azadeh Nadjarzadeh, Roghayyeh Masoumi, Ameneh Marzban, Seyed Ahmad Mohajeri, Nahid Ramezani-Jolfaie, Amin Salehi-AbargoueiEffect of saffron (Crocus sativus L.) on lipid profile, glycemic indices and antioxidant status among overweight/obese prediabetic individuals: A double-blinded, randomized controlled trialClin Nutr ESPEN.(2019 Dec)
    19. L-Carnitine - Jonathan P JarowUse of carnitine therapy in selected cases of male factor infertility: a double-blind crossover trialJ Urol.(2003 Aug)
    20. Saffron - Safarinejad MR, Shafiei N, Safarinejad SA prospective double-blind randomized placebo-controlled study of the effect of saffron (Crocus sativus Linn.) on semen parameters and seminal plasma antioxidant capacity in infertile men with idiopathic oligoasthenoteratozoospermiaPhytother Res.(2011 Apr)
    21. Shilajit - Biswas TK, Pandit S, Mondal S, Biswas SK, Jana U, Ghosh T, Tripathi PC, Debnath PK, Auddy RG, Auddy BClinical evaluation of spermatogenic activity of processed Shilajit in oligospermiaAndrologia.(2010 Feb)
    22. L-Carnitine - Andrea Garolla, Matilde Maiorino, Alberto Roverato, Antonella Roveri, Fulvio Ursini, Carlo ForestaOral carnitine supplementation increases sperm motility in asthenozoospermic men with normal sperm phospholipid hydroperoxide glutathione peroxidase levelsFertil Steril.(2005 Feb)
    23. Coenzyme Q10 - Lewin A, Lavon HThe effect of coenzyme Q10 on sperm motility and functionMol Aspects Med.(1997)
    24. Vitamin C - Vani K, Kurakula M, Syed R, Alharbi KClinical relevance of vitamin C among lead-exposed infertile menGenet Test Mol Biomarkers.(2012 Sep)
    25. Saffron - Mohammad Heidary, Sepideh Vahhabi, Jahanbakhsh Reza Nejadi, Bahram Delfan, Mehdi Birjandi, Hossein Kaviani, Soudabeh GivradEffect of saffron on semen parameters of infertile menUrol J.(Fall 2008)
    26. L-Carnitine - Moradi M, Moradi A, Alemi M, Ahmadnia H, Abdi H, Ahmadi A, Bazargan-Hejazi SSafety and efficacy of clomiphene citrate and L-carnitine in idiopathic male infertility: a comparative studyUrol J.(2010 Summer)
    27. Coenzyme Q10 - Nadjarzadeh A, Shidfar F, Amirjannati N, Vafa MR, Motevalian SA, Gohari MR, Nazeri Kakhki SA, Akhondi MM, Sadeghi MREffect of Coenzyme Q10 supplementation on antioxidant enzymes activity and oxidative stress of seminal plasma: a double-blind randomised clinical trialAndrologia.(2014 Mar)
    28. Coenzyme Q10 - Nadjarzadeh A, Sadeghi MR, Amirjannati N, Vafa MR, Motevalian SA, Gohari MR, Akhondi MA, Yavari P, Shidfar FCoenzyme Q10 improves seminal oxidative defense but does not affect on semen parameters in idiopathic oligoasthenoteratozoospermia: a randomized double-blind, placebo controlled trialJ Endocrinol Invest.(2011 Sep)
    29. L-Carnitine - Sigman M, Glass S, Campagnone J, Pryor JLCarnitine for the treatment of idiopathic asthenospermia: a randomized, double-blind, placebo-controlled trialFertil Steril.(2006 May)
    30. L-Carnitine - Lenzi A, Sgrò P, Salacone P, Paoli D, Gilio B, Lombardo F, Santulli M, Agarwal A, Gandini LA placebo-controlled double-blind randomized trial of the use of combined l-carnitine and l-acetyl-carnitine treatment in men with asthenozoospermiaFertil Steril.(2004 Jun)
    31. L-Carnitine - Najme Moslemi Mehni, Ali Asghar Ketabchi, Ebrahim HosseiniCombination effect of Pentoxifylline and L-carnitine on idiopathic oligoasthenoteratozoospermiaIran J Reprod Med.(2014 Dec)
    32. Coenzyme Q10 - Giancarlo Balercia, Fabrizio Mosca, Franco Mantero, Marco Boscaro, Antonio Mancini, Giuseppe Ricciardo-Lamonica, GianPaolo LittarruCoenzyme Q(10) supplementation in infertile men with idiopathic asthenozoospermia: an open, uncontrolled pilot studyFertil Steril.(2004 Jan)
    33. L-Carnitine - Khaw SC, Wong ZZ, Anderson R, Martins da Silva Sl-carnitine and l-acetylcarnitine supplementation for idiopathic male infertility.Reprod Fertil.(2020-Jul)