Docosahexaenoic Acid

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    Last Updated: August 28, 2025

    Docosahexaenoic acid (DHA) is an omega-3 fatty acid found in fatty fish and some types of seaweed. DHA is often taken as a supplement in the form of fish oil to improve cardiovascular health and brain health.

    11,098 participants in 9 trials and 1 meta-analysis

    Examine Database: Docosahexaenoic Acid

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    Examine Database References

    1. Depression Symptoms - Marangell LB, Martinez JM, Zboyan HA, Kertz B, Kim HF, Puryear LJA double-blind, placebo-controlled study of the omega-3 fatty acid docosahexaenoic acid in the treatment of major depressionAm J Psychiatry.(2003 May)
    2. Postpartum Depression Symptoms - Makrides M, Gibson RA, McPhee AJ, Yelland L, Quinlivan J, Ryan P; DOMInO Investigative TeamEffect of DHA supplementation during pregnancy on maternal depression and neurodevelopment of young children: a randomized controlled trialJAMA.(2010 Oct 20)
    3. Cerebral Oxygenation - Jackson PA, Reay JL, Scholey AB, Kennedy DODHA-rich oil modulates the cerebral haemodynamic response to cognitive tasks in healthy young adults: a near IR spectroscopy pilot studyBr J Nutr.(2012 Apr)
    4. Infant Birth Weight - Bilgundi K, Viswanatha GL, Purushottam KM, John J, Kamath AP, Kishore A, Nayak PG, Nandakumar KDocosahexaenoic Acid and Pregnancy: A Systematic Review and Meta-Analysis of the Association with Improved Maternal and Fetal Health.Nutr Res.(2024 Aug)
    5. Child behavioral development - Paquet SP, Pronovost E, Simonyan D, Caouette G, Matte-Gagné C, Olivier F, Bartholomew J, Morin A, Mohamed I, Marc I, Guillot MMaternal high-dose docosahexaenoic acid supplementation and neurodevelopment at 5 Years of preterm children.Clin Nutr ESPEN.(2024 Dec)
    6. Wakefulness - Montgomery P, Burton JR, Sewell RP, Spreckelsen TF, Richardson AJFatty acids and sleep in UK children: subjective and pilot objective sleep results from the DOLAB study--a randomized controlled trialJ Sleep Res.(2014 Aug)
    7. Insulin - Woodman RJ, Mori TA, Burke V, Puddey IB, Watts GF, Beilin LJEffects of purified eicosapentaenoic and docosahexaenoic acids on glycemic control, blood pressure, and serum lipids in type 2 diabetic patients with treated hypertensionAm J Clin Nutr.(2002 Nov)
    8. Natural Killer Cell Content - Thies F, Nebe-von-Caron G, Powell JR, Yaqoob P, Newsholme EA, Calder PCDietary supplementation with eicosapentaenoic acid, but not with other long-chain n-3 or n-6 polyunsaturated fatty acids, decreases natural killer cell activity in healthy subjects aged >55 yAm J Clin Nutr.(2001 Mar)
    9. B Cell Count - Kelley DS, Taylor PC, Nelson GJ, Schmidt PC, Ferretti A, Erickson KL, Yu R, Chandra RK, Mackey BEDocosahexaenoic acid ingestion inhibits natural killer cell activity and production of inflammatory mediators in young healthy menLipids.(1999 Apr)
    10. Pre-Eclampsia Risk - Zhou SJ, Yelland L, McPhee AJ, Quinlivan J, Gibson RA, Makrides MFish-oil supplementation in pregnancy does not reduce the risk of gestational diabetes or preeclampsiaAm J Clin Nutr.(2012 Jun)